Optothermal
manipulation is a versatile technique that combines
optical and thermal forces to control synthetic micro-/nanoparticles
and biological entities. This emerging technique overcomes the limitations
of traditional optical tweezers, including high laser power, photon
and thermal damage to fragile objects, and the requirement of refractive-index
contrast between target objects and the surrounding solvents. In this
perspective, we discuss how the rich opto-thermo-fluidic multiphysics
leads to a variety of working mechanisms and modes of optothermal
manipulation in both liquid and solid media, underpinning a broad
range of applications in biology, nanotechnology, and robotics. Moreover,
we highlight current experimental and modeling challenges in the pursuit
of optothermal manipulation and propose future directions and solutions
to the challenges.