Optothermal microbubble assisted manufacturing of nanogap-rich structures for active chemical sensing

Karim, Farzia; Vasquez, Erick S.; Sun, Yvonne; Zhao, Chenglong

doi:10.1039/c9nr05892c

Cited by 28 publications

(55 citation statements)

References 53 publications

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“…Inset: schematic of a gold-nanosphere and gold-nanoshell. 23 Figure 5.17 shows the SERS spectrum of 1 µM R6G collected by gold-nanoshell-structure and gold-nanosphere-structure. SERS intensity of R6G at 1364 cm -1 in Figure 5.17…”

Section: Sers Spectra Of R6g Collected By Two Nanogap-rich Structuresmentioning

confidence: 99%

“…Inset: schematic of passive sensing illustrates free diffusion of analytes towards nanogap-richstructure. 23 14 Normalized Raman intenisty of R6G at 1364 cm -1 without goldnanoshell-structure (blue curve) and with gold-nanoshell-structure (red curve). Inset (top) depicts magnified Raman spectrum of 10 mM R6G without goldnanoshell-structure.…”

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confidence: 99%

“…Inset (bottom) illustrates schematic of passive sensing method is applied to record these data. 23 For more than several decades, food safety has become a significant global health concern since food-borne diseases correspond to a widespread and increasing public health problem all over the world. Over the last 20 years, food-borne diseases have been increased significantly in the developed as well as developing countries.…”

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confidence: 99%

“…Normalized SERS intensity of R6G at 1364 cm -1 as a function of R6G concentration by active sensing (solid line) and passive sensing (dashed line) 23. ............…”

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confidence: 99%

“…Simulated electric field profile of (a) gold nanosphere array (b) gold nanoshell (silica core) array at an exciting laser wavelength of 785 nm. Inset: schematic structure of (a) gold nanosphere array (b) gold nanoshell (silica core) array 23. ...............................................................................................................................…”

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confidence: 99%

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Active and Ultrasensitive Chemical and Biosensing through Optothermally Generated Microbubble

Karim

Sun

Vasquez

et al. 2020

Conference on Lasers and Electro-Optics

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Rapid and sensitive detection of harmful chemicals or biological samples is essential for medical study and industrial applications. For example, in the food industry, it is an urgent demand to detect hazardous chemicals or pathogens and then efficiently eliminate contaminated sources from the food production chain to protect people from toxic food-borne infection. In addition, toxic chemicals, pesticides and pathogens are also responsible for water, air and soil contamination. Therefore, rapid and sensitive detection of toxic chemicals or pathogens are very important to ensure food safety and evaluating environmental pollution. Most of the sensing systems for detecting chemical or biological samples apply a passive sensing method, in which binding of analytes to the sensor happens through free diffusion. Due to this free diffusion of analytes in a passive sensing method, diffusing process takes several hours even days, especially when the analytes are at low concentrations and therefore suffer from so called diffusion limit. A higher sensitivity can be achieved in passive sensing methods, with nanoscale sensors but at a cost of reduced speed and vice versa. Therefore, speed and sensitivity of sensing need to be traded off. Active sensing methods, in which analytes are actively concentrated towards the sensor, can be used to break the diffusion limit of sensing and significantly improve the sensitivity. In this work, an ultrasensitive and cost-effective chemical and biosensing platform has been developed under ambient condition to demonstrate active sensing of analytes. This method v works based on an optothermally generated microbubble (OGMB). OGMB is a micronsized bubble that is generated on a liquid-solid interface through laser heating. Due to the strong convective flow induced by OGMB, nanoparticles or analytes can be attracted towards the OGMB and deposited on the surface of a substrate. We have successfully fabricated nanogap-rich structures by generating an OGMB on a glass substrate. The nanoparticles in the nanogap-rich structures form many nanogaps that are ideal for surface enhance Raman scattering (SERS) due to the plasmonic resonance of nanogap-rich structures. Analytes for example any chemical or biological samples can be actively concentrated on the nanogap-rich structure for SERS detection. The OGMB-assisted active sensing method can improve the detection limit of analytes by an order of magnitude compared to that with a passive sensing and thus overcome the diffusion limit of conventional passive sensing methods. Therefore, we expect that, OGMB-assisted active sensing method will find potential applications in advanced chemical and bio-sensing. DEDICATION vi Dedicated to my mother who is my pride, inspiration, strength and my life. vii ACKNOWLEDGMENTS At the beginning, all the praise to Almighty for giving me the capability for successful completion of this work. I would like to express my sincere indebtedness to all who have given me the chance to finish this research. Without their generous sup...

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Section: Sers Spectra Of R6g Collected By Two Nanogap-rich Structuresmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

“…Normalized SERS intensity of R6G at 1364 cm -1 as a function of R6G concentration by active sensing (solid line) and passive sensing (dashed line) 23. ............…”

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confidence: 99%

mentioning

confidence: 99%

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Active and Ultrasensitive Chemical and Biosensing through Optothermally Generated Microbubble

Karim

Sun

Vasquez

et al. 2020

Conference on Lasers and Electro-Optics

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Bubble‐pen lithography: Fundamentals and applications

Kollipara

Mahendra

et al. 2022

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Developing on-chip functional devices requires reliable fabrication methods with high resolution for miniaturization, desired components for enhanced performance, and high throughput for fast prototyping and mass production. Recently, laser-based bubble-pen lithography (BPL) has been developed to enable sub-micron linewidths, in situ synthesis of custom materials, and on-demand patterning for various functional components and devices. BPL exploits Marangoni convection induced by a laser-controlled microbubble to attract, accumulate, and immobilize particles, ions, and molecules onto different substrates. Recent years have witnessed tremendous progress in theory, engineering, and application of BPL, which motivated us to write this review. First, an overview of experimental demonstrations and theoretical understandings of BPL is presented. Next, we discuss the advantages of BPL and its diverse applications in quantum dot displays, biological and chemical sensing, clinical diagnosis, nanoalloy synthesis, and microrobotics. We conclude this review with our perspective on the challenges and future directions of BPL.

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Sensitivity‐Enhancing Strategies in Optical Biosensing

Kim

Gonzales

Zheng

2020

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High‐sensitivity detection of minute quantities or concentration variations of analytes of clinical importance is critical for biosensing to ensure accurate disease diagnostics and reliable health monitoring. A variety of sensitivity‐improving concepts have been proposed from chemical, physical, and biological perspectives. In this review, elements that are responsible for sensitivity enhancement are classified and discussed in accordance with their operating steps in a typical biosensing workflow that runs through sampling, analyte recognition, and signal transduction. With a focus on optical biosensing, exemplary sensitivity‐improving strategies are introduced, which can be developed into “plug‐and‐play” modules for many current and future sensors, and discuss their mechanisms to enhance biosensing performance. Three major strategies are covered: i) amplification of signal transduction by polymerization and nanocatalysts, ii) diffusion‐limit‐breaking systems for enhancing sensor–analyte contact and subsequent analyte recognition by fluid‐mixing and analyte‐concentrating, and iii) combined approaches that utilize renal concentration at the sampling and recognition steps and chemical signal amplification at the signal transduction step.

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Optothermal microbubble assisted manufacturing of nanogap-rich structures for active chemical sensing

Abstract: Fabrication of nanogap-rich structures and active chemical sensing through an optothermally generated microbubble (OGMB).

Cited by 28 publications

References 53 publications

Active and Ultrasensitive Chemical and Biosensing through Optothermally Generated Microbubble

Active and Ultrasensitive Chemical and Biosensing through Optothermally Generated Microbubble

Bubble‐pen lithography: Fundamentals and applications

Sensitivity‐Enhancing Strategies in Optical Biosensing

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