Optogenetics-Inspired Fluorescent Synaptic Devices with Nonvolatility

Abstract

Given the synergy of optogenetics and bioimaging in neuroscience, it is possible for light to simultaneously modulate and visualize synaptic events of optoelectronic synaptic devices, which are building blocks of a neuromorphic computing system with optoelectronic integration. Here we demonstrate the realization of the simultaneous modulation and visualization of synaptic events by using optically stimulated synaptic devices based on the heterostructure of fluorescent silicon quantum dots (Si QDs) and monolayer molybdenum disulfide (MoS 2 ). The charge-transferenabled photogating effect of the Si QDs/MoS 2 heterostructure leads to the nonvolatility of the synaptic devices, which exhibit important synaptic functionalities and synchronous fluorescence upon optical stimulation. An array of the Si QDs/MoS 2 optoelectronic synaptic devices is well-employed to mimic robust neural population coding. Defective devices in this array may be pinpointed by the absence of their fluorescence. This work has an important implication for the development of synaptic devices facilitating the system-level diagnosis and device-level positioning of a neuromorphic computing system.

Thiol-Responsive Polypeptide Sulfur Dioxide Prodrug Nanoparticles for Effective Tumor Inhibition

“…Recently, the ptoluenesulfonamide units of one polymer were reported to serve as a moiety targeting the endoplasmic reticulum (ER) membrane, and thus the polymeric NPs could upregulate ER stress-related protein expression, boosting calcium ion efflux and activating the caspase-12 signaling cascade in cancer cells. 44 Therefore, we could predict that PTSC NPs target the ER membrane, trigger ER stress, and finally promote cancer cell death when internalized. This is speculated to be the underlying reason for the 34.4% apoptosis rate observed with the PTSC control NPs.…”

Recent progress in low‐swellable polymer‐based smart photonic crystal sensors

“…[133] The real breakthrough in low-and anti-swelling hydrogels came in 2014 when Sakai et al reported a non-swellable polymer without mechanical hysteresis. [134] Since then, a series of multi-purpose advanced functional hydrogels with high strength, [135][136][137] electrical conductivity, [138,139] self-healing, [140,141] adhesion, [142,143] injectability, [144] and other functions have been actively developed, swelling hydrogels have been rapidly developed.…”

Enhanced Multiwavelength Response of Flexible Synaptic Transistors for Human Sunburned Skin Simulation and Neuromorphic Computation

“…[33,38,39] To enhance the photosensitive properties of LSSTs, researchers have explored the incorporation of chlorophyll into organic transistors, enabling the mimicry of basic functions such as synaptic plasticity and image recognition. [40] Wang et al [41] demonstrated photonic synaptic devices based on the heterostructure of fluorescent silicon quantum dots and monolayer molybdenum disulfide, which promote the charge transfer process. Furthermore, photoresponsive synapse transistors and pulse-time dependency were achieved by leveraging the inherent photoconductive properties of porous oxide semiconductors.…”

“…[ 40 ] Wang et al. [ 41 ] demonstrated photonic synaptic devices based on the heterostructure of fluorescent silicon quantum dots and monolayer molybdenum disulfide, which promote the charge transfer process. Furthermore, photoresponsive synapse transistors and pulse‐time dependency were achieved by leveraging the inherent photoconductive properties of porous oxide semiconductors.…”