Optogenetic fMRI for Brain-Wide Circuit Analysis of Sensory Processing

Lee, Jeong-Yun; You, Taeyi; Woo, Choong‐Wan; Kim, Seong‐Gi

doi:10.3390/ijms232012268

Cited by 12 publications

(5 citation statements)

References 110 publications

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“…Correspondingly, the sensitivity of optogenetic-fMRI is thought to potentially underreport wholebrain responses when used to stimulate small areas (Lee et al, 2022).…”

Section: Potential Subtle Effectsmentioning

confidence: 99%

The Effects of Locus Coeruleus Optogenetic Stimulation on Global Spatiotemporal Patterns in Rats

Anumba,

Kelberman,

Pan

et al. 2024

Preprint

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Whole-brain intrinsic activity as detected by resting-state fMRI can be summarized by three primary spatiotemporal patterns. These patterns have been shown to change with different brain states, especially arousal. The noradrenergic locus coeruleus (LC) is a key node in arousal circuits and has extensive projections throughout the brain, giving it neuromodulatory influence over the coordinated activity of structurally separated regions. In this study, we used optogenetic-fMRI in rats to investigate the impact of LC stimulation on the global signal and three primary spatiotemporal patterns. We report small, spatially specific changes in global signal distribution as a result of tonic LC stimulation, as well as regional changes in spatiotemporal patterns of activity at 5 Hz tonic and 15 Hz phasic stimulation. We also found that LC stimulation had little to no effect on the spatiotemporal patterns detected by complex principal component analysis. These results show that the effects of LC activity on the BOLD signal in rats may be small and regionally concentrated, as opposed to widespread and globally acting.

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“…Correspondingly, the sensitivity of optogenetic-fMRI is thought to potentially underreport wholebrain responses when used to stimulate small areas (Lee et al, 2022).…”

Section: Potential Subtle Effectsmentioning

confidence: 99%

The Effects of Locus Coeruleus Optogenetic Stimulation on Global Spatiotemporal Patterns in Rats

Anumba,

Kelberman,

Pan

et al. 2024

Preprint

View full text Add to dashboard Cite

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“…Functional magnetic resonance imaging (fMRI) has been instrumental in elucidating the neural circuitry of emotional regulation, providing high spatial resolution to identify specific brain regions involved in this complex process (Lee et al, 2022;Neacsiu et al, 2018). fMRI studies consistently highlight the pivotal roles of the prefrontal cortex (PFC), amygdala, hippocampus, and anterior cingulate cortex (ACC).…”

Section: Functional Magnetic Resonance Imaging (Fmri)mentioning

confidence: 99%

The neural circuitry of emotional regulation: evidence from multimodal imaging

Bardel,

Gross,

Neacsiu

2024

BrainBridge

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This Research synthesizes current research on the neural circuitry of emotional regulation, focusing on evidence derived from multimodal imaging studies. We provide a comprehensive overview of the key brain regions and neurochemical pathways implicated in emotional regulation, as elucidated by functional magnetic resonance imaging (fMRI), positron emission tomography (PET), and electroencephalography (EEG). Our analysis highlights the central roles of the prefrontal cortex, amygdala, hippocampus, and anterior cingulate cortex in modulating emotional responses, while also emphasizing the dynamic interplay between these regions. Findings from fMRI studies underscore the involvement of cognitive reappraisal strategies mediated by the prefrontal cortex, while PET studies reveal the neurochemical underpinnings of emotional regulation, including serotonin and dopamine systems. EEG studies provide insights into the temporal dynamics of brain activity during emotional processing, elucidating the rapid interplay between cortical and subcortical structures. Despite significant advancements, limitations such as study design constraints and sample size limitations underscore the need for continued research efforts. Future research directions include advancements in imaging technology, longitudinal studies, and exploration of individual differences in emotional regulation. By addressing these research priorities, we can deepen our understanding of emotional regulation and its implications for mental health, ultimately informing more targeted and effective interventions for individuals with emotional disorders.

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“…The potential for STN DBS to produce activation or inhibition in various related, yet anatomically distinct brain regions makes functional magnetic resonance imaging (fMRI) an ideal tool to decipher the circuit mechanisms governing therapeutic STN DBS. fMRI enables mapping whole-brain evoked responses in an unbiased manner, and such brain-wide patterns of activity changes during different stimulation parameters represent critical information to reveal the precise neural circuit changes that are necessary for therapeutic STN DBS [15][16][17][18][19][20][21] .…”

Section: Introductionmentioning

confidence: 99%

Optogenetic fMRI reveals therapeutic circuits of subthalamic nucleus deep brain stimulation

Li,

Lee,

et al. 2024

Preprint

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SummaryWhile deep brain stimulation (DBS) is widely employed for managing motor symptoms in Parkinson’s disease (PD), its exact circuit mechanisms remain controversial. To identify the neural targets affected by therapeutic DBS in PD, we analyzed DBS-evoked whole brain activity in female hemi-parkinsonian rats using function magnetic resonance imaging (fMRI). We delivered subthalamic nucleus (STN) DBS at various stimulation pulse repetition rates using optogenetics, allowing unbiased examinations of cell-type specific STN feed-forward neural activity. Unilateral STN optogenetic stimulation elicited pulse repetition rate-dependent alterations of blood-oxygenation-level-dependent (BOLD) signals in SNr (substantia nigra pars reticulata), GP (globus pallidus), and CPu (caudate putamen). Notably, these manipulations effectively ameliorated pathological circling behavior in animals expressing the kinetically faster Chronos opsin, but not in animals expressing ChR2. Furthermore, mediation analysis revealed that the pulse repetition rate-dependent behavioral rescue was significantly mediated by optogenetically induced activity changes in GP and CPu, but not in SNr. This suggests that the activation of GP and CPu are critically involved in the therapeutic mechanisms of STN DBS.

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Optogenetic fMRI for Brain-Wide Circuit Analysis of Sensory Processing

Cited by 12 publications

References 110 publications

The Effects of Locus Coeruleus Optogenetic Stimulation on Global Spatiotemporal Patterns in Rats

The Effects of Locus Coeruleus Optogenetic Stimulation on Global Spatiotemporal Patterns in Rats

The neural circuitry of emotional regulation: evidence from multimodal imaging

Optogenetic fMRI reveals therapeutic circuits of subthalamic nucleus deep brain stimulation

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