Optogenetic action potentials and intrinsic pacemaker interplay in retrogradely identified midbrain dopamine neurons
Niklas Hammer,
Pascal Vogel,
Sanghun Lee
et al.
Abstract:Dissecting the diversity of midbrain dopamine (DA) neurons by optotagging is a promising addition to better identify their functional properties and contribution to motivated behavior. Retrograde molecular targeting of DA neurons with specific axonal projection allows further refinement of this approach. Here, we focus on adult mouse DA neurons in the substantia nigra pars compacta (SNc) projecting to dorsal striatum (DS) by demonstrating the selectivity of a floxed AAV9‐based retrograde channelrhodopsin‐eYFP … Show more
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