Optofluidic microcapillary biosensor for label-free, low glucose concentration detection

Wan, Hongdan; Chen, Jijing; Wan, Cheng; Zhou, Quan; Wang, Jie; Zhang, Zuxing

doi:10.1364/boe.10.003929

Cited by 33 publications

(17 citation statements)

References 17 publications

(16 reference statements)

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“…[96][97][98] Similarly, based on the specific catalytic effect of enzymes on substrates, some OFOF biochemical sensors based on enzymatic reactions have been proposed. [76,99,100] In conclusion, a variety of molecular recognition forms provide guidelines for the preparation of OFOF biochemical sensors. In the future research, if some novel molecular recognition can be developed and combined with fiber-optic sensing technology, the application range of fiber-optic biochemical sensors can be broadened.…”

Section: Molecular Recognitionmentioning

confidence: 99%

“…[174] In 2019, Wan et al proposed a label-free glucose sensor with a low detection limit of 2.78 mm by fixing the GOD on the inner surface of the optofluidic microcapillary. [76] Because the microcapillary-based WGM coupling system is sensitive to external environmental signals, it is susceptible to interference from external environmental, such as, temperature fluctuations, airflow disturbances, noise signals, etc. The external interference will reduce the detection limit of the sensor and make the measurement results inaccurate.…”

Section: Microcapillary Resonatorsmentioning

confidence: 99%

See 1 more Smart Citation

Optical Fiber Optofluidic Bio‐Chemical Sensors: A Review

Zhang

Zhou

et al. 2021

Laser & Photonics Reviews

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Optofluidic, as an emerging technology that combines photons and microfluidics, has become a powerful, intelligent, and universal sensing platform in the field of bio-chemical sensing. Optical fiber optofluidic (OFOF), as a branch of optofluidic technology, has stimulated a host of remarkable achievements in the field of bio-chemical sensing due to its superiority of compact structure, immunity to electromagnetic interference, low sample consumption, high sensitivity, and real-time dynamic response. In this paper, an overview of OFOF bio-chemical sensors is presented. The OFOF system architectures are introduced and some advanced functional materials and coating technologies that can be utilized in the OFOF sensing platform to achieve high-performance biochemical sensing are summarized. Research progress and current status of OFOF bio-chemical sensors based on various sensing mechanisms are summarized and analyzed, with emphases on their sensing principles, sensing structures, sensing applications, advantages, and disadvantages. Lastly, the existing challenges and future development trends of OFOF biochemical sensors are briefly discussed.

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Section: Molecular Recognitionmentioning

confidence: 99%

Section: Microcapillary Resonatorsmentioning

confidence: 99%

Optical Fiber Optofluidic Bio‐Chemical Sensors: A Review

Zhang

Zhou

et al. 2021

Laser & Photonics Reviews

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“…[ 49,50 ] For biomedical‐related studies, it offers a key route to break new ground on multi‐functional “lab‐on‐a‐chip” systems with a small footprint, streamlined protocol, low required sample volume, and ideally high throughput. [ 51–55 ]…”

Section: Silicon Photonics For Label‐free Biosensingmentioning

confidence: 99%

Silicon‐Based Integrated Label‐Free Optofluidic Biosensors: Latest Advances and Roadmap

Wang

Sánchez

Yin

et al. 2020

Adv Materials Technologies

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By virtue of the well‐developed micro‐ and nanofabrication technologies and rapidly progressing surface functionalization strategies, silicon‐based devices have been widely recognized as a highly promising platform for the next‐generation lab‐on‐a‐chip bioanalytical systems with a great potential for point‐of‐care medical diagnostics. Herein, an overview of the latest advances in silicon‐based integrated optofluidic label‐free biosensing technologies relying on the efficient interactions between the evanescent light field at the functionalized surface and specifically bound analytes is presented. State‐of‐the‐art technologies demonstrating label‐free evanescent wave‐based biomarker detection mainly encompass three device configurations, including on‐chip waveguide‐based interferometers, microring resonators, and photonic‐crystal‐based cavities. Moreover, up‐to‐date strategies for elevating the sensitivities and also simplifying the sensing processes are discussed. Emerging laboratory prototypes with advanced integration and packaging schemes incorporating automatic microfluidic components or on‐chip optoelectronic devices lead to one significant step forward in real applications of decentralized diagnostics. Besides, particular attention is paid to currently commercialized label‐free optical bioanalytical models on the market. Finally, the prospects are elaborated with several research routes toward chip‐scale, low‐cost, highly sensitive, multi‐functional, and user‐friendly bioanalytical systems benefiting to global healthcare.

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“…Capillary, or fiber-based WGM sensors have also been explored due to their ease of integration with microfluidics, large binding surface area, and high Q-factor [ 122 , 141 ]. Using a microcapillary (MC) fabricated from optical fiber, Wan et al [ 141 ] were able to detect the concentration of glucose. The wall thickness of the capillary was optimized for sensitivity, based on the FDTD method for a capillary filled with a fluid.…”

Section: Whispering Gallery Mode (Wgm)-based Biosensorsmentioning

confidence: 99%

Label-Free Optical Resonator-Based Biosensors

Rho

Breaux

Kim

2020

Sensors

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The demand for biosensor technology has grown drastically over the last few decades, mainly in disease diagnosis, drug development, and environmental health and safety. Optical resonator-based biosensors have been widely exploited to achieve highly sensitive, rapid, and label-free detection of biological analytes. The advancements in microfluidic and micro/nanofabrication technologies allow them to be miniaturized and simultaneously detect various analytes in a small sample volume. By virtue of these advantages and advancements, the optical resonator-based biosensor is considered a promising platform not only for general medical diagnostics but also for point-of-care applications. This review aims to provide an overview of recent progresses in label-free optical resonator-based biosensors published mostly over the last 5 years. We categorized them into Fabry-Perot interferometer-based and whispering gallery mode-based biosensors. The principles behind each biosensor are concisely introduced, and recent progresses in configurations, materials, test setup, and light confinement methods are described. Finally, the current challenges and future research topics of the optical resonator-based biosensor are discussed.

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Optofluidic microcapillary biosensor for label-free, low glucose concentration detection

Cited by 33 publications

References 17 publications

Optical Fiber Optofluidic Bio‐Chemical Sensors: A Review

Optical Fiber Optofluidic Bio‐Chemical Sensors: A Review

Silicon‐Based Integrated Label‐Free Optofluidic Biosensors: Latest Advances and Roadmap

Label-Free Optical Resonator-Based Biosensors

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