Optofluidic fabrication for 3D-shaped particles

Paulsen, Kevin S.; Carlo, Dino Di; Chung, Aram J.

doi:10.1038/ncomms7976

Cited by 109 publications

(104 citation statements)

References 51 publications

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“…Such an approach opens up the computer-aided design and manufacturing of shaped polymer fibers 13 and particles 14 for a range of applications. Additional uses in directing mass and heat transfer and transferring solutions for automation of biological sample preparation should also benefit.…”

Section: Discussionmentioning

confidence: 99%

“…uFlow is built on top of computationally expensive solutions to the Navier-Stokes equations, 12 but as a standalone product, it uses lightweight, pre-computed advection maps, relieving the end-user of time consuming calculations. Using this framework, manual pillar programming has been successfully employed for shaping polymer precursors for streams 13 and particles, 14,15 reducing inertial flow focusing positions, 16 and solution transfer around particles. 17 Such manual exploration of flow deformations will quickly run up against the combinatorial phase space of possible pillar combinations.…”

Section: Introductionmentioning

confidence: 99%

“…19 Decreasing the channel length can not only reduce the pressure drop to improve the performance of the device but also provide more space downstream for applications, for example, complex 3D shaped particle fabrication or particle separation and solution exchange. [13][14][15]17 Therefore, an optimization scheme is needed to enhance the capability of pillar programming while still remaining accessible to, and easily implementable by, an interested researcher with modest computing hardware. Although pillar diameter will play a role in the required pressure to drive flow through a micropillar sequence, we have determined that microchannel length has a greater overall impact on pressure drop (more information available in the supplementary material 20 ).…”

Section: Introductionmentioning

confidence: 99%

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Optimization of micropillar sequences for fluid flow sculpting

Stoecklein

Kim

et al. 2016

Physics of Fluids

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Inertial fluid flow deformation around pillars in a microchannel is a new method for controlling fluid flow. Sequences of pillars have been shown to produce a rich phase space with a wide variety of flow transformations. Previous work has successfully demonstrated manual design of pillar sequences to achieve desired transformations of the flow cross section, with experimental validation. However, such a method is not ideal for seeking out complex sculpted shapes as the search space quickly becomes too large for efficient manual discovery. We explore fast, automated optimization methods to solve this problem. We formulate the inertial flow physics in microchannels with different micropillar configurations as a set of state transition matrix operations. These state transition matrices are constructed from experimentally validated streamtraces for a fixed channel length per pillar. This facilitates modeling the effect of a sequence of micropillars as nested matrix-matrix products, which have very efficient numerical implementations. With this new forward model, arbitrary micropillar sequences can be rapidly simulated with various inlet configurations, allowing optimization routines quick access to a large search space. We integrate this framework with the genetic algorithm and showcase its applicability by designing micropillar sequences for various useful transformations. We computationally discover micropillar sequences for complex transformations that are substantially shorter than manually designed sequences. We also determine sequences for novel transformations that were difficult to manually design. Finally, we experimentally validate these computational designs by fabricating devices and comparing predictions with the results from confocal microscopy. C 2016 AIP Publishing LLC. [http://dx

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Optimization of micropillar sequences for fluid flow sculpting

Stoecklein

Kim

et al. 2016

Physics of Fluids

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“…Therefore, C-particles constitute important interpolating shapes between rods and rings which can * Electronic address: choell@thphy.uni-duesseldorf.de † Electronic address: hlowen@thphy.uni-duesseldorf.de show significant, but not perfect entanglement. It is important to note that C-shape colloids can be nowadays fabricated at wish [23,24] such that our model is realized.…”

Section: Introductionmentioning

confidence: 99%

Colloidal suspensions of C-particles: Entanglement, percolation and microrheology

Hoell

Löwen

2016

The Journal of Chemical Physics

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We explore structural and dynamical behavior of concentrated colloidal suspensions made up by C-shape particles using Brownian dynamics computer simulations and theory. In particular, we focus on the entanglement process between nearby particles for almost closed C-shapes with a small opening angle. Depending on the opening angle and the particle concentration, there is a percolation transition for the cluster of entangled particles which shows the classical scaling characteristics. In a broad density range below the percolation threshold, we find a stretched exponential function for the dynamical decorrelation of the entanglement process. Finally, we study a set-up typical in microrheology by dragging a single tagged particle with constant speed through the suspension. We measure the cluster connected to and dragged with this tagged particle. In agreement with a phenomenological theory, the size of the dragged cluster depends on the dragging direction and increases markedly with the dragging speed.

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“…[26,31,32] Mask-assisted selective polymerization of photo-curable solution in microchannel can fabricate nonspherical microparticles with flexible shapes depending on their mask, [25,33] and the flow configuration. [34,35] Alternatively, monodisperse emulsion droplets from microfluidics, with versatile shapes, provide excellent templates for engineering uniform nonspherical microparticles. Deformed droplets confined by microchannel with different dimensions, [26,27] Janus droplets with one curable hemisphere, [31,36] and evolved acorn-shaped droplets from double emulsions, [32] can be generated from microfluidics for fabricating nonspherical microparticles with different shapes.…”

mentioning

confidence: 99%

Controllable Microfluidic Fabrication of Microstructured Materials from Nonspherical Particles to Helices

Wang

Zhang

et al. 2017

Macromol. Rapid Commun.

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delivery, [1] drug release, [8] assembling, [9,10] packing, [11,12] and magnetic-driven motion. [13,14] For example, cylindrical microstructured materials self-assembled from copolymers can persist in the blood circulation of rodents ten times longer than their spherical counterparts. [2] Helical microstructured materials can convert rotational motion into translational motion in liquid media, such as water and blood, under remote control of a rotated magnetic field, showing great potential for many applications. [13,15] With such unique motion behaviors, helical microstructured materials can be utilized for uses such as picking and placing of microcargo, [14] mixing and pumping of fluid, [16] remote sensing of pH, [17] drilling of bovine tissues, [18] and cancer hyperthermia. [19] Thus, creation of uniform microstructured materials with versatile nonspherical and helical shapes is crucial for achieving advanced functions.Generally, microstructured materials with nonspherical and helical shapes can be produced by methods such as film-based extension of spherical microparticles, [20][21][22] mold-based template synthesis, [23,24] microfluidic-based template synthesis, [8,[25][26][27] and polymerization induced by 3D direct laser writing. [14] For example, incorporation of polystyrene-based microparticles in polymeric film, followed with 1D or 2D film extension, can produce various nonspherical microparticles. [20][21][22] By confining precursor solutions in differently shaped microwells of molds, nonspherical microparticles with flexible shapes can also be produced. [23,24] With excellent manipulation of microflows, [28][29][30] microfluidic technique provides a powerful platform for fabricating nonspherical microparticles with versatile structures and compositions. [26,31,32] Mask-assisted selective polymerization of photo-curable solution in microchannel can fabricate nonspherical microparticles with flexible shapes depending on their mask, [25,33] and the flow configuration. [34,35] Alternatively, monodisperse emulsion droplets from microfluidics, with versatile shapes, provide excellent templates for engineering uniform nonspherical microparticles. Deformed droplets confined by microchannel with different dimensions, [26,27] Janus droplets with one curable hemisphere, [31,36] and evolved acorn-shaped droplets from double emulsions, [32] can be generated from microfluidics for fabricating nonspherical microparticles with different shapes. However, for the above-mentioned methods, it is difficult to produce microstructured materials with complex Microstructured MaterialsThis work reports on a facile and flexible strategy based on the deformation of encapsulated droplets in fiber-like polymeric matrices for template synthesis of controllable microstructured materials from nonspherical microparticles to complex 3D helices. Monodisperse droplets generated from microfluidics are encapsulated into crosslinked polymeric networks via an interfacial crosslinking reaction in microchannel to in situ produce the droplet-...

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Optofluidic fabrication for 3D-shaped particles

Cited by 109 publications

References 51 publications

Optimization of micropillar sequences for fluid flow sculpting

Optimization of micropillar sequences for fluid flow sculpting

Colloidal suspensions of C-particles: Entanglement, percolation and microrheology

Controllable Microfluidic Fabrication of Microstructured Materials from Nonspherical Particles to Helices

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