Optofluidic Concentration: Plasmonic Nanostructure as Concentrator and Sensor

Escobedo, Carlos; Brolo, Alexandre G.; Gordon, Reuven; Sinton, David

doi:10.1021/nl204504s

Cited by 122 publications

(117 citation statements)

References 40 publications

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“…Second, many real-life analytes such as environmental contaminants and explosives may be dispersed in liquid or gas phases or may be bound to solid substrates (e.g., soil), which may require the use of nonaqueous solvents for extraction. Various approaches have been explored to improve SERS sensitivity in aqueous solvents (16,28,29). Among them, using superhydrophobic surfaces to overcome the "diffusion limit" of analytes in highly diluted aqueous solutions is the most successful technique (16).…”

mentioning

confidence: 99%

Ultrasensitive surface-enhanced Raman scattering detection in common fluids

Yang

Dai

Stogin

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

619

442

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Detecting target analytes with high specificity and sensitivity in any fluid is of fundamental importance to analytical science and technology. Surface-enhanced Raman scattering (SERS) has proven to be capable of detecting single molecules with high specificity, but achieving single-molecule sensitivity in any highly diluted solutions remains a challenge. Here we demonstrate a universal platform that allows for the enrichment and delivery of analytes into the SERSsensitive sites in both aqueous and nonaqueous fluids, and its subsequent quantitative detection of Rhodamine 6G (R6G) down to ∼75 fM level (10 −15 mol·L −1 ). Our platform, termed slippery liquidinfused porous surface-enhanced Raman scattering (SLIPSERS), is based on a slippery, omniphobic substrate that enables the complete concentration of analytes and SERS substrates (e.g., Au nanoparticles) within an evaporating liquid droplet. Combining our SLIPSERS platform with a SERS mapping technique, we have systematically quantified the probability, p(c), of detecting R6G molecules at concentrations c ranging from 750 fM (p > 90%) down to 75 aM (10 −18 mol·L −1 ) levels (p ≤ 1.4%). The ability to detect analytes down to attomolar level is the lowest limit of detection for any SERS-based detection reported thus far. We have shown that analytes present in liquid, solid, or air phases can be extracted using a suitable liquid solvent and subsequently detected through SLIPSERS. Based on this platform, we have further demonstrated ultrasensitive detection of chemical and biological molecules as well as environmental contaminants within a broad range of common fluids for potential applications related to analytical chemistry, molecular diagnostics, environmental monitoring, and national security.spectroscopy | sensing | SERS | slippery surfaces | nanoparticles

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mentioning

confidence: 99%

Ultrasensitive surface-enhanced Raman scattering detection in common fluids

Yang

Dai

Stogin

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

619

442

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“…Second, the sensor can be integrated into a small chip, so it can be used for miniatured and multiplexing detection system. In addition, it shows that by flowing analytes through system, the limit of detection can be improved significantly, as the flow-through configuration solves the mass-transport problem on the sensor surface [97, 98]. This is especially important for detection of extremely low concentration analytes.…”

Section: Applicationsmentioning

confidence: 99%

Patterned Plasmonic Surfaces—Theory, Fabrication, and Applications in Biosensing

Chorsi

Zhu

Zhang

2017

J. Microelectromech. Syst.

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Low-profile patterned plasmonic surfaces are synergized with a broad class of silicon microstructures to greatly enhance near-field nanoscale imaging, sensing, and energy harvesting coupled with far-field free-space detection. This concept has a clear impact on several key areas of interest for the MEMS community, including but not limited to ultra-compact microsystems for sensitive detection of small number of target molecules, and “surface” devices for optical data storage, micro-imaging and displaying. In this paper, we review the current state-of-the-art in plasmonic theory as well as derive design guidance for plasmonic integration with microsystems, fabrication techniques, and selected applications in biosensing, including refractive-index based label-free biosensing, plasmonic integrated lab-on-chip systems, plasmonic near-field scanning optical microscopy and plasmonics on-chip systems for cellular imaging. This paradigm enables low-profile conformal surfaces on microdevices, rather than bulk material or coatings, which provide clear advantages for physical, chemical and biological-related sensing, imaging, and light harvesting, in addition to easier realization, enhanced flexibility, and tunability.

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“…Apart from propagating surface plasmon-polaritons (SPP) present on dielectric-metal interfaces [1,2], isolated and periodic nanoparticles support localized surface plasmon resonances (LSPR) [3][4][5][6]. The resulting large field enhancement and tightly confined has been exploited in a plethora of applications such as surface-enhanced Raman spectroscopy [7][8][9], biosensing [10][11][12][13], reflective [14,15] and transmissive [16][17][18] optical filters, and vacuum Rabbi oscillations [19][20][21]. In addition, extraordinary optical transmission, attributed to LSPR and SPP, has been observed in subwavelength metallic hole arrays [22][23][24][25][26].…”

mentioning

confidence: 99%

Hybrid Coupling Mechanism in a System Supporting High Order Diffraction, Plasmonic, and Cavity Resonances

et al. 2014

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The interactions between plasmonic and photonic modes of a cavity-coupled plasmonic crystal are studied in diffraction and diffractionless regimes, which lead us to the understanding of coherent interactions between electron plasma, higher order cavity, and diffraction modes. The strong interaction between plasmonic and photonic modes is shown to enhance as well as suppress surface plasmon resonance based on cavity phase relation. Numerical and analytical approaches are developed to accurately explain the physics of the interactions evident in their characteristic dispersion graphs. Further experimental measurements confirm the theoretical predictions.

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Optofluidic Concentration: Plasmonic Nanostructure as Concentrator and Sensor

Cited by 122 publications

References 40 publications

Ultrasensitive surface-enhanced Raman scattering detection in common fluids

Ultrasensitive surface-enhanced Raman scattering detection in common fluids

Patterned Plasmonic Surfaces—Theory, Fabrication, and Applications in Biosensing

Hybrid Coupling Mechanism in a System Supporting High Order Diffraction, Plasmonic, and Cavity Resonances

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