Optoelectronic, Photocatalytic, and DNA interaction studies of synthesised Cu(II), Co(II), and Ni(II) complexes containing schiff base ligand

Cancer has become the second leading reason for death in the world. Cell biology states that the bulk of anti‐cancer medications focuses on DNA. A study of how complexes of metals interact with DNA is crucial in creation of the effective chemotherapy drugs. The interactions of DNA with Schiff base and their metal complexes are a thrust area for many researchers, and many papers have reported on them. An amino molecule reacts with carbonyl group to form a variety of chemicals called Schiff bases. Many studies have shown that Schiff bases have compounds that affect biological processes. Due to their potential use as novel reagents for biotechnology and medicine, the research of interactions between transition metal complexes and nucleic acids has grown significantly during the past few decades. It was shown that several metal Schiff base complexes may intercalate DNA. Small molecules can attach themselves to DNA through different ways, such as intercalation and groove binding. The main method to measure nuclease activity was gel electrophoresis, and the ligand alone had much lower activity than the complex. To set the stage for this analysis, a brief overview of Schiff bases and their complexes is provided. Further, this review provides an overview of the DNA interactions brought forth by Schiff base metal complexes. It also draws attention to new developments in the study of Schiff bases and their metal complexes and their prospective use as a bioactive core for DNA cleavage and binding.

Section: Intercalationmentioning

confidence: 82%

“…Complexes of Cu (II), Co (II), and Ni (II) were reported by Kirthan et al 95 using an azomethine ligand, specifically [5‐(diethylamino)‐2‐hydroxyphenyl]methylidene)benzohydrazide] (Figure 14). The newly synthesized ligand and its metal complexes were studied using elemental and spectroscopical analysis.…”

Section: Dna Interactionmentioning

confidence: 83%

Recent advances on the DNA interaction properties of Schiff bases and their metal complexes

Yadav,

Poonia

2024

“…Further binding strength is generally evaluated by calculating the intrinsic binding constant K b by applying Wolfe-Shimmer equation. 42,43 The Kb values for all the systems under investigation have been calculated and presented in Table 5. The results obtained indicated an effectual intercalative mode of binding to DNA with affinity order for both ligand and complexes as Complexes…”

Section: Uv-vis Absorption Studiesmentioning

confidence: 99%

Experimental and theoretical studies on structural aspects of transition metal complexes of isonicotinoyl N‐oxide hydrazone: Their DNA‐binding interaction and cytotoxicity

Anitha,

Jhansi Lakshmi,

Mudavath

et al. 2023

Equilibrium studies of isonicotinoyl N‐oxide hydrazone [4‐(2‐(4‐(diethylamino)‐2‐hydroxybenzylidene) hydrazine carbonyl) pyridine1‐oxide] were carried out by employing pH‐metric titrations in 40% DMF‐H2O medium at 303 K and 0.1 M ionic strength, to investigate its ligation properties. Quantitative structure activity relationship (QSAR) and molecular orbital properties were evaluated by applying HyperChem 7.5 tools. The title compound and its Cu (II), Ni (II), and Zn (II) complexes were characterized by various spectro analytical tools, namely, Fourier‐transform infrared spectroscopy, 1H‐nuclear magnetic resonance, liquid chromatography‐mass spectrometry, UV‐Vis, thermogravimetric analysis–differential thermal analysis, scanning electron microscope (SEM)–energy‐dispersive X‐ray, electron spin resonance, and X‐ray diffraction (XRD) studies. Infrared data provided information about the chelating properties of ligand and coordination sites in metal complexes. The electronic spectral studies of complexes inferred the symmetry‐based spin allowed electronic transitions and charge transfer (CT) transitions. Mass spectral studies, elemental analysis, and thermal studies of complexes confirmed the composition of the metal complexes. The surface texture and nanocrystalline nature of solid compounds were studied by SEM and XRD methods. The antioxidant activities of all the compounds were determined by DPPH radical scavenging method. DNA‐binding interactions of the synthesized compounds with calf thymus (CT)‐DNA were studied by absorption and fluorescence methods. Antioxidant and antimicrobial studies indicated their potentiality as active agents. Cytotoxicity measurements of title compounds for IC50 values on MCF‐7 cell line, and docking scores of these compounds with chosen target, computed by employing AutoDock software indicated their potential for anticancer properties.

Design, preparation, physicochemical characterization, structural conformational, biological evaluation, and DNA interaction for some new benzimidazole complexes

Abu‐Dief,

El‐Khatib,

El‐Dabea

et al. 2024

New Cu (II), VO (II), Ag(I), and Pd (II)‐[BIP = 4,6‐dimethyl‐N‐(octahydro‐2H‐benzimidazol‐2‐ylidene)pyrimidin‐2‐amine] chelates have been synthesized by the reaction of BIP ligand resulting from the condensation of benzimidazole guanidine as well as acetylacetone with tested metal salts. The suggested structures of prepared compounds have been investigated spectroscopically through (FT‐IR, NMR, Mass spectra, and UV–Vis spectra), CHN analyses, conductivity, pH stability as well asmagnetic moment measurements. TGA studies have been also studied to govern the thermal behavior, stability, and decomposition of the metal chelates. Structural study of the tested chelates exposed their chemical transformation of ligand by chelation with the studied metals. The studies predicted a hexa‐coordinated geometry for the Cu and VO chelates, whereas tetra‐coordinated for the Ag and Pd chelates. DFT/B3LYP theoretical method was applied to obtain optimized geometry, molecular electrostatic potential (MEP) surface, and HOMO‐LUMO analysis for tested compounds. For estimation in the in vitro study, all the tested compounds have been screened for their biochemical features, including antioxidant, antimicrobial performances, and cytotoxicity. The antioxidant performance of prepared molecules has been studied by DPPH study and all the tested chelates displayed close antioxidant performance against the standard drugs. The cytotoxic analysis of tested compounds has been estimated against various cancer cell lines: (Hep‐G2, HCT‐116, and MCF‐7) using MTT analysis as well as calculated the cell viability for the corresponding human cell. The DNA binding capability for the tested compounds has been evaluated through absorption spectroscopic, viscosity estimation, as well as gel electrophoresis. The outcomes displayed a good binding tendency through the binding constant from 1.01 × 104 to 1.99 × 104 M−1 in the order BIPCu> BIPVO > BIPPd > BIPAg, respectively. Finally, docking simulation results indicated that the complexes were located in the intercalation site of DNA and confirmed experimental findings.