Optoacoustic tomography utilizing focused transducers: The resolution study

Khokhlova, Tanya D.; Pelivanov, Ivan; Karabutov, Alexander A.

doi:10.1063/1.2834855

Cited by 27 publications

(20 citation statements)

References 12 publications

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“…39 Taking into consideration ultrasound attenuation and diffraction loss during propagation, 14,40 and a limited frequency band of detection, the amplitude would be reduced by at least four orders of magnitude. 25,28,41 However, a focused thin-film PVDF-based transducer can detect a pressure signal on the level of ten Pa 14,25 for frequencies up to 10 MHz. Therefore, a minimum 20-dB signal-to-noise ratio of the detected PA signal by a contrastagent-targeted single tumor cell would be feasible.…”

Section: Discussionmentioning

confidence: 99%

Suppression of background signal in magnetomotive photoacoustic imaging of magnetic microspheres mimicking targeted cells

et al. 2012

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Abstract. Contrast-enhanced photoacoustic (PA) imaging has been proposed to identify circulating metastatic cancer cells magnetically trapped in the vasculature. However, its sensitivity is limited by the presence of a strong blood-background signal. This technique can be further improved by the significant suppression of blood background. In the phantom study presented here, significant background suppression is demonstrated with magnetomotive photoacoustic imaging. Magnetic particles with a mean diameter of 10 μm were integrated (concentration of 0.05 mg∕ml) into an ink-water solution with an optical absorption coefficient of 5 cm −1 to mimic cells targeted with magnetic nanoparticles and magnetically trapped in the human vasculature. Two mechanically moveable permanent magnets were used to accumulate microparticles in the investigated solution and manipulate them within a thin, 1.6-mm-diameter Teflon tube mimicking a blood vessel. Our results clearly indicate that the undesirable background can be effectively suppressed using the difference of PA images corresponding to different locations of accumulated particles.

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Section: Discussionmentioning

confidence: 99%

Suppression of background signal in magnetomotive photoacoustic imaging of magnetic microspheres mimicking targeted cells

et al. 2012

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“…The geometrical characteristics of the cylindrically focused elements result in a sensitivity field with calculated full width half maximum (FWHM) dimensions in the xz-plane at 15 MHz of ∼ 530 μm around the focus in the transverse dimension, and about 2 cm for the depth-of-field (27) . Therefore, the minimum spatial sampling along the x-axis (translation direction) should be set so that the sensitivity patterns for two successive laser shots are contiguous.…”

Section: 32spatial Samplingmentioning

confidence: 99%

“…The journal version is the definitive version. 27 for the three phantoms. Along the z-axis, the FWHM resolution R FWHM z is similar for the three phantoms.…”

Section: 1resolution and Field-of-view With Isotropic Objectsmentioning

confidence: 99%

Single-side access, isotropic resolution, and multispectral three-dimensional photoacoustic imaging with rotate-translate scanning of ultrasonic detector array

et al. 2015

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(200 words).Photoacoustic imaging can achieve high-resolution three-dimensional visualization of optical absorbers at penetration depths ~ 1 cm in biological tissues by detecting optically-induced high ultrasound frequencies. Tomographic acquisition with ultrasound linear arrays offers an easy implementation of single-side access, parallelized and high-frequency detection, but usually comes with an image quality impaired by the directionality of the detectors. Indeed, a simple translation of the array perpendicularly to its median imaging plane is often used, but results both in a poor resolution in the translation direction and in strong limited view artifacts. To improve the spatial resolution and the visibility of complex structures while keeping a planar detection geometry, we introduce, in this paper, a novel rotate-translate scanning scheme, and investigate the performance of a scanner implemented at 15 MHz center frequency. The developed system achieved a quasi-isotropic uniform 3D resolution of ~170 µm over a cubic volume of side length 8.5 mm, i.e. an improvement in the resolution in the translation direction by almost one order of magnitude. Dual wavelength imaging was also demonstrated with ultrafast wavelength shifting. The validity of our approach was shown in vitro. We discuss the ability to enable in vivo imaging for preclinical and clinical studies. Keywords: photoacoustics, ultrasound array, tomography, multispectral.This manuscript has been published as : J Gateau, M Gesnik, JM Chassot, E Bossy; "Single-side access, isotropic resolution, and multispectral three-dimensional photoacoustic imaging with rotate-translate scanning of ultrasonic detector array," J. Biomed. Opt., 20(5), 056004 (2015). The journal version is the definitive version. This manuscript has been published as : J Gateau, M Gesnik, JM Chassot, E Bossy; "Single-side access, isotropic resolution, and multispectral three-dimensional photoacoustic imaging with rotate-translate scanning of ultrasonic detector array," J. Biomed. Opt., 20(5), 056004 (2015). The journal version is the definitive version.3

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“…In such case, the diffraction equation does not have an analytic solution. It has been shown [10] that the numerical solution of the diffraction equation for a wideband OA signal can be well described by the analytical solution of the problem for continuous ultrasound using certain wavelength. The width of the spectrum is limited by both the diffraction of optoacoustic signal and transducer transient response.…”

Section: Theoretical Modelmentioning

confidence: 99%

“…In ref. [10], the relationship between the resolution and the flare angle of an antenna was numerically calculated and experimentally confirmed for the case of spherically focused radiator of continuous ultrasound waves. However, the relationship between the parameters of the antenna and the required resolution should be known to obtain an antenna with the given characteristics of reconstructed image.…”

Section: Introductionmentioning

confidence: 99%

Wideband focused transducer array for optoacoustic tomography

2009

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Abstract:In this work, a multi-element transducer has been developed for the optoacoustic tomography of biological objects with a given spatial resolution in three dimensions (axial resolution in the image plane was ∆x = 0.1 mm, lateral resolution in the image plane was ∆z = 1.6 mm, lateral resolution in the plane perpendicular to the image plane was ∆y = 0.5 mm). The transducer consists of a set of 8 linear PVDF piezoelectric films (width is 2 mm) located in a plane with 1-mm gap and focused by a cylindrical acoustic lens. Map of the transducer focal area has been experimentally investigated. The resolution ∆y was obtained from the map and is equal to 0.5 mm. Image of a focused point source has been rendered based on experimentally obtained optoacoustic signals. The x-axis resolution and the z-axis resolution were calculated from the focused point source image reconstructed using a back-projection algorithm and are equal to 0.1 mm and 2 mm respectively.

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Optoacoustic tomography utilizing focused transducers: The resolution study

Cited by 27 publications

References 12 publications

Suppression of background signal in magnetomotive photoacoustic imaging of magnetic microspheres mimicking targeted cells

Suppression of background signal in magnetomotive photoacoustic imaging of magnetic microspheres mimicking targeted cells

Single-side access, isotropic resolution, and multispectral three-dimensional photoacoustic imaging with rotate-translate scanning of ultrasonic detector array

Wideband focused transducer array for optoacoustic tomography

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