Optoacoustic Imaging and Gray-Scale US Features of Breast Cancers:                    Correlation with Molecular Subtypes

Dogan, Basak E.; Menezes, Gisela L. G.; Butler, Reni; Neuschler, Erin; Aitchison, Roger; Lavin, Philip T.; Tucker, F. Lee; Grobmyer, Stephen R.; Otto, Pamela M; Stavros, A. Thomas

doi:10.1148/radiol.2019182071

Cited by 49 publications

(40 citation statements)

References 33 publications

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“…Development of molecular imaging probes to target specific breast-cancer receptors (estrogen receptor and human epidermal growth factor receptor 2 [HER2]) would enhance the molecular characterization (73), allowing for better treatment with hormonal therapy and trastuzumab. In addition, optoacoustic imaging coupled with standard grayscale US has differentiated HER2-positive and triple-negative breast cancers from luminal cancers (74). This further suggests the possible capability to differentiate HER2-positive breast cancers from triple-negative cancers, which exhibits high clinical significance as a noninvasive breast-cancer characterization technique (74).…”

Section: Clinical Msot Applicationsmentioning

confidence: 99%

“…In addition, optoacoustic imaging coupled with standard grayscale US has differentiated HER2-positive and triple-negative breast cancers from luminal cancers (74). This further suggests the possible capability to differentiate HER2-positive breast cancers from triple-negative cancers, which exhibits high clinical significance as a noninvasive breast-cancer characterization technique (74).…”

Section: Clinical Msot Applicationsmentioning

confidence: 99%

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Development of Multispectral Optoacoustic Tomography as a Clinically Translatable Modality for Cancer Imaging

MacCuaig

Jones

Abeyakoon

et al. 2020

Radiology: Imaging Cancer

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The use of optoacoustic imaging takes advantage of the photoacoustic effect to generate high-contrast, high-resolution medical images at penetration depths of up to 5 cm. Multispectral optoacoustic tomography (MSOT) is a type of optoacoustic imaging system that has seen promising preclinical success with a recent emergence into the clinic. Multiwavelength illumination of tissue allows for the mapping of multiple chromophores, which are generated endogenously or exogenously. However, translation of MSOT to the clinic is still in its preliminary stages. For successful translation, MSOT requires refinement of probes and data-acquisition systems to tailor to the human body, along with more intuitive, real-time visualization settings. The possibilities of optoacoustic imaging, namely MSOT, in the clinic are reviewed here.

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Section: Clinical Msot Applicationsmentioning

confidence: 99%

Section: Clinical Msot Applicationsmentioning

confidence: 99%

Development of Multispectral Optoacoustic Tomography as a Clinically Translatable Modality for Cancer Imaging

MacCuaig

Jones

Abeyakoon

et al. 2020

Radiology: Imaging Cancer

View full text Add to dashboard Cite

show abstract

“…The four tumor subtypes, luminal A (LUMA), luminal B (LUMB), triple negative breast cancer (TNBC), and human epidermal growth factor receptor type 2 enhanced (HER2-E), and their characteristics [69][70][71][72] are presented in Table 3. Menezes et al 73 reviewed results from the Maestro trial, and Dogan et al 74 reviewed results from the Pioneer trial to investigate whether tumor subtypes could be differentiated based on PA/US features. The studies found that the internal PA features (functional characteristics such as Hb, HbO 2 , and sO 2 ) and the peripheral vasculature played an important role in this classification process, along with the US feature of sound transmission (based on tumor anatomy 75 ).…”

Section: Pa Features For Breast Imagingmentioning

confidence: 99%

Photoacoustic imaging of breast cancer: a mini review of system design and image features

2019

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Breast cancer is one of the leading causes for cancer related deaths in women, and early detection is extremely important to improve survival rates. Currently, x-ray mammogram is the only modality for mass screening of asymptomatic women. However, it has decreased sensitivity in radiographically dense breasts, which is also associated with a higher risk for breast cancer. Photoacoustic (PA) imaging is an emerging modality that enables deep tissue imaging of optical contrast at ultrasonically defined spatial resolution, which is much higher than that can be achieved in purely optical imaging modalities. Because of high optical absorption from hemoglobin molecules, PA imaging can map out hemo distribution and dynamics in breast tissue and identify malignant lesions based on tumor associated angiogenesis and hypoxia. We review various PA breast imaging systems proposed over the past few years and summarize the PA features of breast cancer identified in these systems.

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“…They used PA-US features to differentiate between breast cancer molecular subtypes. Dogan et al [114] performed a detailed analysis on dual-mode PA US images of 532 IBC lesions of 519 patients from the PIONEER study. They correlated PA-US features with breast molecular subtypes.…”

Section: In Vivo Studiesmentioning

confidence: 99%

“…They also found that the same features could be useful to differentiate between LUMA and TNBC from other molecular subtypes. Dogan et al [114] performed a detailed analysis on dual mode PA US images of 532 IBC lesions of 519 patients from the PIONEER study. They reported that the means of total external PA-US feature scores, i.e., boundary zone, peripheral zone vessels for luminal (A and B) breast cancers were higher, and total internal PA-US features scores, i.e., internal vessels, internal blush, and internal hemoglobin were lower than that of the triple-negative and HER2positive breast cancers.…”

Section: Question 2: What Are the Pathophysiological Factors Behind Tmentioning

confidence: 99%

Photoacoustic Imaging for Management of Breast Cancer: A Literature Review and Future Perspectives

2020

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In this review article, a detailed chronological account of the research related to photoacoustic imaging for the management of breast cancer is presented. Performing a detailed analysis of the breast cancer detection related photoacoustic imaging studies undertaken by different research groups, this review attempts to present the clinical evidence in support of using photoacoustic imaging for breast cancer detection. Based on the experimental evidence obtained from the clinical studies conducted so far, the performance of photoacoustic imaging is compared with that of conventional breast imaging modalities. While we find that there is enough experimental evidence to support the use of photoacoustic imaging for breast cancer detection, additional clinical studies are required to be performed to evaluate the diagnostic potential of photoacoustic imaging for identifying different types of breast cancer. To establish the utility of photoacoustic imaging for breast cancer screening, clinical studies with high-risk asymptomatic patients need to be done.

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Optoacoustic Imaging and Gray-Scale US Features of Breast Cancers: Correlation with Molecular Subtypes

Abstract: Seno Medical Instruments provided equipment and financial support for this study.

Cited by 49 publications

References 33 publications

Development of Multispectral Optoacoustic Tomography as a Clinically Translatable Modality for Cancer Imaging

Development of Multispectral Optoacoustic Tomography as a Clinically Translatable Modality for Cancer Imaging

Photoacoustic imaging of breast cancer: a mini review of system design and image features

Photoacoustic Imaging for Management of Breast Cancer: A Literature Review and Future Perspectives

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