Optoacoustic detection and monitoring of blast-induced intracranial hematomas in rats

Petrov, Andrey; Wynne, Karon E.; Prough, Donald S.; DeWitt, Douglas S.; Petrov, Yuriy; Petrov, Irene Y.; Parsley, Margaret A.; Esenaliev, Rinat O.

doi:10.1117/12.2045357

Cited by 5 publications

(4 citation statements)

References 7 publications

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“…We developed and built a medical-grade optoacoustic system, described in detail in [16][17][18][19][20] . The system utilizes an optical parametric oscillator (OPO), the Opolette HE 532 (Opotek Inc., Carlsbad, CA), as a source of pulsed nearinfrared (NIR) light in the wavelength range of 680-950 nm, a pulse width of about 6 ns, and a pulse repetition rate of 20 Hz.…”

Section: Methodsmentioning

confidence: 99%

“…The SSS, a large central cerebral vein, drains all blood from the brain and represents an important site of monitoring. Recently, we developed and built a medical-grade optoacoustic system for optoacoustic imaging, monitoring, and sensing [16][17][18][19][20][21] . In this work we performed pilot clinical tests of the system in the reflection and transmission modes in infants, including LBW and VLBW infants.…”

Section: Introductionmentioning

confidence: 99%

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Monitoring cerebral venous blood oxygenation in neonates with a medical-grade optoacoustic system

et al. 2015

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Premature, very-low-birth-weight (VLBW; ≤1500 g) and low-birth-weight (LBW; 1500-2499 g) infants are at increased risk for severe neurological disability. 25-50% of the 63,000 VLBW infants born annually in the USA have major longterm cognitive or neurobehavioral deficits in which cerebral hypoxia plays an important role. At present, no technology is capable of noninvasive, accurate monitoring of cerebral oxygenation in newborns. We proposed to use an optoacoustic technique for noninvasive cerebral hypoxia monitoring by probing the superior sagittal sinus (SSS). Recently, we developed and built a medical grade, multi-wavelength, near-infrared optoacoustic system suitable for neonatal applications. We designed and built an adjustable patient interface for neonates with VLBW, LBW, and normal weight (NBW) that provides single or continuous measurements of the SSS blood oxygenation in both the reflection and transmission modes. We performed pilot clinical tests of the system in VLBW, LBW, and NBW hemodynamically stable infants admitted to the neonatal intensive care unit. The system was capable of detecting SSS signals through the open anterior and posterior fontanelles and through the skull and allowed for monitoring of the SSS blood oxygenation in both modes. To the best of our knowledge this paper reports for the first time detection of optoacoustic signals from human cerebral blood vessels in both the transmission mode and the reflection mode. Analysis of the signals allows for noninvasive measurement of cerebral venous blood oxygenation in newborns in both modes. The transmission mode can be used for accurate measurement of the total hemoglobin concentration as well. The method and system proposed in this study can be used for optoacoustic human brain imaging, tomography, and mapping.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Monitoring cerebral venous blood oxygenation in neonates with a medical-grade optoacoustic system

et al. 2015

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“…The system utilizes an optical parametric oscillator (OPO), the Opolette HE 532 (Opotek Inc., Carlsbad, CA), as a source of pulsed near-infrared (NIR) light in the wavelength range of 680-950 nm with a pulse width of about 6 ns and a pulse repetition rate of 20 Hz. Wide-band, highly-sensitive optoacoustic probes were developed in our laboratory for monitoring, imaging, and sensing in reflection and transmission modes [1][2][3][4][5][11][12][13][14][15][16][17][18][19][20][21][22][23] . The laser light was delivered to the probe through fiber-optic systems specially developed for the reflection and transmission modes.…”

Section: Methodsmentioning

confidence: 99%

Optoacoustic measurements of human placenta and umbilical blood oxygenation

Nanovskaya

Petrov

et al. 2016

SPIE Proceedings

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Adequate oxygenation is essential for normal embryogenesis and fetal growth. Perturbations in the intrauterine oxidative environment during pregnancy are associated with several pathophysiological disorders such as pregnancy loss, preeclampsia, and intrauterine growth restriction. We proposed to use optoacoustic technology for monitoring placental and fetal umbilical blood oxygenation. In this work, we studied optoacoustic monitoring of oxygenation in placenta and umbilical cord blood ex vivo using technique of placenta perfusion. We used a medical grade, nearinfrared, tunable, optoacoustic system developed and built for oxygenation monitoring in blood vessels and in tissues. First, we calibrated the system for cord blood oxygenation measurements by using a CO-Oximeter (gold standard). Then we performed validation in cord blood circulating through the catheters localized on the fetal side of an isolated placental lobule. Finally, the oxygenation measurements were performed in the perfused placental tissue. To increase or decrease blood oxygenation, we used infusion of a gas mixture of 95% O2 + 5% CO2 and 95% N2 + 5% CO2, respectively. In placental tissue, up to four cycles of changes in oxygenation were performed. The optoacoustically measured oxygenation in circulating cord blood and in placental lobule closely correlated with the actual oxygenation data measured by CO-Oximeter. We plan to further test the placental and cord blood oxygenation monitoring with optoacoustics in animal and clinical studies.

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“…(iv) The Airy line ensemble appears as the limit at the boundary between the frozen and liquid regions for a very general class of random lozenge tilings, see [4], also [22,[35][36][37] for earlier convergence results and work on related models. The Airy kernel has also been found at the more delicate liquid-gas boundary in the Aztec diamond [7,8].…”

Section: Introductionmentioning

confidence: 99%

Bulk properties of the Airy line ensemble

Dauvergne

Virág

2021

Ann. Probab.

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The parabolic Airy line ensemble A is a central limit object in the KPZ universality class and related areas. On any compact set K = {1, . . . , k} × [a, a + t], the law of the recentered ensemble A−A(a) has a density X K with respect to the law of k independent Brownian motions. We show thatwhere S is an explicit, tractable, non-negative function of f . We use this formula to show that X K is bounded above by a K-dependent constant, give a sharp estimate on the size of the set where X K < ǫ as ǫ → 0, and prove a large deviation principle for A. We also give density estimates that take into account the relative positions of the Airy lines, and prove sharp two-point tail bounds that are stronger than those for Brownian motion. The paper is essentially self-contained, requiring only tail bounds on the Airy point process and the Brownian Gibbs property as inputs.1. Almost surely, L satisfies L i (r) > L i+1 (r) for all pairs (i, r) ∉ 1, k × (0, t).

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Optoacoustic detection and monitoring of blast-induced intracranial hematomas in rats

Cited by 5 publications

References 7 publications

Monitoring cerebral venous blood oxygenation in neonates with a medical-grade optoacoustic system

Monitoring cerebral venous blood oxygenation in neonates with a medical-grade optoacoustic system

Optoacoustic measurements of human placenta and umbilical blood oxygenation

Bulk properties of the Airy line ensemble

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