Soybean [Glycine max (L.) Merr.] seeding rate research across North America is typically conducted in small geo-political regions where environmental effects on the seeding rate × yield relationship are minimized. Data from 211 individual field studies (∼21,000 data points, 2007-2017) were combined from across North America ranging in yield from 1,000-7,500 kg ha −1 . Cluster analysis was used to stratify each individual field study into similar environmental (soil × climate) clusters and into high (HYL), medium (MYL), and low (LYL) yield levels. Agronomically optimal seeding rates (AOSR) were calculated and Monte Carlo risk analysis was implemented. Within the two northern most clusters the AOSR was higher in the LYL followed by the MYL and then HYL. Within the farthest south cluster, a relatively Abbreviations: AOSR, agronomically optimal seeding rate; CIPAR, cumulatively intercepted photosynthetically active radiation; HYL, high yield level; LYL, low yield level; MYL, medium yield level; NCCPI, national commodity crop productivity index; PAR, photosynthetically active radiation; VRS, variable rate seeding.This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.