Optimizing totally intracorporeal pure Studer robot-assisted neobladder - Technique and outcomes after initial 13 cases

Petruț, Bogdan; Bujoreanu, E.C.; Hârdo, V.V.; Coste, Bogdan Ovidiu; Maghiar, Teodor

doi:10.1016/s0302-2838(21)01618-3

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“…In the surgical treatment of adult renal cell carcinoma (RCC), the most commonly used tumor recognition technique is near-infrared fluorescence imaging based on indocyanine green (ICG) (4). Due to the different uptake of ICG between the tumor and the normal renal tissue, when ICG enters the kidney through blood circulation, they show different fluorescence types that hypofluorescence or afluorescence in the tumor and hyperfluorescence in the normal kidney.…”

Section: Introductionmentioning

confidence: 99%

Clinical application of indocyanine green fluorescence imaging navigation for pediatric renal cancer

Feng,

Yang,

Qin

et al. 2023

Front. Pediatr.

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BackgroundIndocyanine Green (ICG) fluorescence imaging has been widely used in the surgical treatment of adult renal cancers, but its application in pediatric renal cancers has rarely been reported. This study aims to summarize the experience of ICG fluorescence imaging in pediatric renal cancers and explores its safety and feasibility.MethodsThe clinical features, surgical information, ICG administration regimen, near infrared radiography data in vivo and ex vivo and pathological results of children with renal cancers using ICG navigation were analyzed and summarized.ResultsThere were 7 cases of renal cancer, including 4 cases of Wilms tumor (WT), 1 case of malignant rhabdoid tumor of the kidney (MRTK) and 2 cases of renal cell carcinoma (RCC). By intraoperative intravenous injection of ICG from 2.5 to 5 mg (0.05–0.67 mg/kg), the tumors were visualized in 6 cases in vivo or ex vivo, and the tumor visualization failed in 1 case due to renal artery embolization before operation. By injecting 5 mg ICG into the normal renal tissue during the operation, 3 patients achieved fluorescent localization of sentinel lymph nodes. No ICG-related adverse reactions were found in any of the patients during or after operation.ConclusionsICG fluorescence imaging is safe and feasible for renal cancers in children. Intraoperative administration can achieve tumor and sentinel lymph node visualization which will facilitate the development of nephron sparing surgery (NSS). However, the technique is affected by ICG dose, anatomical conditions around the tumor, and renal blood flow. A proper dose of ICG and the complete removal of perirenal fat are helpful for the fluorescence imaging of the tumor. It has potential in the operation of renal cancer in children.

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Section: Introductionmentioning

confidence: 99%