Optimizing the searching for H. pylori in clinical practice with EndoFasterⓇ

Zullo, Angelo; Germanà, B.; Galliani, E.; Iori, Andrea; Pretis, G. De; Manfredi, Guido; Buscarini, Elisabetta; Buonocore, Matteo Rossano; Monica, Fabio

doi:10.1016/j.dld.2021.02.004

Cited by 13 publications

(18 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…H. pylori diagnosis was based on the determination of ammonium concentration, as a consequence of the urease activity of the bacterium within 30–90 s, that is, during endoscopy. H. pylori infection was diagnosed when the ammonium concentration was >62 ppm/ml and negative when ≤62 ppm/ml, as reported elsewhere [7,10].…”

Section: Methodsmentioning

confidence: 99%

“…Fortunately, the incidence of H. pylori is decreasing in developed countries [5]. Indeed, two multicentre, endoscopic studies found an H. pylori prevalence of 34% in 2012 and 22.3% in 2020, respectively, in Italy [6,7], and a value as low as 10% was computed in a large histological database in the USA [8]. Therefore, when gastric biopsies are performed during endoscopy, H. pylori is absent in several patients, particularly in those aged less than 50 years [9].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, in a preliminary study, EndoFaster was found to be useful in detecting H. pylori infection in some patients with chronic active gastritis without a clear presence of bacteria at standard histological evaluation, avoiding the need for further diagnostic tests [12]. The initial version of the device required aspiration until 6 ml of gastric juice to perform analysis, an amount not detectable in all patients [7,10]. The technical performance of device was improved so that with the new machine until to 3 ml of gastric juice are needed.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Real-time gastric juice analysis with EndoFaster for H. pylori diagnosis: a large, multicentre study

Zullo

Germanà²,

Galliani³

et al. 2022

European Journal of Gastroenterology &Amp; Hepatology

Self Cite

View full text Add to dashboard Cite

Background Helicobacter pylori infection is the main cause of the most frequent gastroduodenal diseases. Because its prevalence is decreasing in developed countries, gastric biopsies are negative in several patients. By measuring ammonium in the gastric juice, EndoFaster allows to exclude H. pylori infection during endoscopy. This study aimed to assess the accuracy of device versions working with either 6 ml or 3 ml of gastric juice. Study design This prospective study involved 12 endoscopic units. During endoscopy, EndoFaster testing was performed and standard five gastric biopsies were taken. The accuracy was calculated by considering histological assessment as the gold standard for H. pylori diagnosis. Results Gastric juice analysis was attempted in 1279 patients, but it failed in 131 (15.5%) and in 10 (2.3%), with the 6 ml and the 3 ml device, respectively (P < 0.001). Overall, EndoFaster detected H. pylori infection with an 86.3% sensitivity, 83.3% specificity, 52.7% positive predictive value, 96.6% negative predictive value and 83.8% accuracy. The performance was not affected either by ongoing proton pump inhibitor therapy or a previous H. pylori eradication. No significant difference in accuracy emerged between the two versions of the device. Conclusion The novel version of the EndoFaster device operating with 3 ml gastric juice may be performed in virtually all patients, and it allows excluding H. pylori infection with a very high accuracy. Gastric biopsies can be avoided in a definite portion of cases without endoscopic lesions or other clinical indications.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Real-time gastric juice analysis with EndoFaster for H. pylori diagnosis: a large, multicentre study

Zullo

Germanà²,

Galliani³

et al. 2022

European Journal of Gastroenterology &Amp; Hepatology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Moreover, the overall benefits of this device include being less invasive, not requiring proton pump inhibitor (PPI) discontinuation before testing, and less costs. Recent studies have demonstrated the EndoFaster has advantages in detection of hypochlorhydric conditions, neoplastic risk conditions, and as an adjunct to gastroesophageal reflux (GERD) treatment (Zullo et al, 2021).…”

Section: New Innovative Tool (Endofaster)mentioning

confidence: 99%

Endoscopic Diagnosis for H. pylori Infection: White Light Imaging (WLI) vs. Image-Enhanced Endoscopy (IEE)

Chatrangsun

Vilaichone

2021

Asian Pac J Cancer Prev

View full text Add to dashboard Cite

infection. However, each technique has some limitations. For example, patients who use proton pump inhibitor PPI), antibiotics, anti-platelet, anti-coagulant, or direct oral anti-coagulant (DOAC) medications. Real-time endoscopy along with conventional white light imaging WLI) and image-enhanced endoscopic (IEE) techniques, such as narrow-band imaging (NBI), linked color imaging (LCI) and blue laser imaging (BLI), appear to have important roles in clinical practice to identify H. pylori-infected status (Malfertheiner et al., 2007). This article aimed to review the endoscopic diagnostic options and findings for H. pylori infection. Current diagnostic tests for H. pylori infectionMany diagnostic tests are available, including invasive

show abstract

“…Therefore, by considering the results of this assessment as the gold standard, EndoFaster accuracy could be even better. Moreover, data of some recent studies found that a cutoff of >62 ppm/mL is the most performing value for Endofaster in detecting H. pylori infection 4,5. Therefore, this cutoff value, rather than ≥57 and >67 ppm/mL, could be tested in their study by considering the results of immunochemistry as the gold standard.…”

mentioning

confidence: 99%