Optimizing the photodynamic therapeutic effect of BODIPY-based photosensitizers against cancer and bacterial cells

Masood, Muhammad Amir; Wu, Yanping; Chen, Yuncong; Yuan, Hao; Sher, Naila; Faiz, Faisal; Yao, Shankun; Qi, Fen; Khan, M. Irfan; Ahmed, Mushtaq; Mushtaq, Nadia; He, Weijiang; Guo, Zijian

doi:10.1016/j.dyepig.2022.110255

Cited by 12 publications

(10 citation statements)

References 49 publications

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“…As examples, Nile blue A is mainly used with living cells, which fix it and give a blue color to cell nuclei [1]. It has also been applied to textiles and other products, such as leather, cosmetics, pulp and paper, pharmaceuticals, plastics, and foods [2][3][4][5]. In view of what was said previously, Nile blue A is very often used for various purposes and is therefore likely to be found in addition to other classes of chemical compounds in various types of liquid effluents, for example, biological, pharmaceutical, agro-food, and textile effluents.…”

Section: Effect Of Ph On the Peak Current And Potentialmentioning

confidence: 99%

“…Nile blue A (bis [5-Amino-9-(diethylamino)benzo[a]phenoxazin-7-ium] sulphate) is an azo dye of the phenoxazine family [1]. It finds applications in histology and medicine for the detection of micro-organisms [2], as well as in photodynamic therapy for the treatment of malignant tumors [3,4]. It is also applied in dye-sensitized solar cells [5].…”

Section: Introductionmentioning

confidence: 99%

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Hydroxyapatite/L-Lysine Composite Coating as Glassy Carbon Electrode Modifier for the Analysis and Detection of Nile Blue A

et al. 2022

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An amperometric sensor was developed by depositing a film coating of hydroxyapatite (HA)/L-lysine (Lys) composite material on a glassy carbon electrode (GCE). It was applied for the detection of Nile blue A (NBA). Hydroxyapatite was obtained from snail shells and its structural properties before and after its combination with Lys were characterized using X-ray diffraction (XRD), Fourier-transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and Brunauer–Emmett–Teller (BET) surface area analyses. The coupling of Lys to HA was attributed to favorable interaction between negatively charged -COO− groups of Lys and divalent ions Ca2+ of HA. Electrochemical investigations pointed out the improvement in sensitivity of the GCE/Lys/HA sensor towards the detection of NBA in solution. The dependence of the peak current and potential on the pH, scan rate, and NBA concentration was also investigated. Under optimal conditions, the GCE/Lys/HA sensor showed a good reproducibility, selectivity, and a NBA low detection limit of 5.07 × 10−8 mol L−1. The developed HA/Lys-modified electrode was successfully applied for the detection of NBA in various water samples.

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Section: Effect Of Ph On the Peak Current And Potentialmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hydroxyapatite/L-Lysine Composite Coating as Glassy Carbon Electrode Modifier for the Analysis and Detection of Nile Blue A

et al. 2022

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“…In a recent publication, Masood et al reported two cationic BODIPY derivatives effective against cancer cells and antibiotic-resistant E. coli and S. aureus strains. 31 An oxygen self-supplying BODIPY compound was demonstrated to inhibit P. aeruginosa by relieving hypoxia to boost the PDT effect. 32 A neutral BODIPY derivative was demonstrated to kill S. aureus , P. aeruginosa , and C. albicans among 15 BODIPY compounds.…”

Section: Introductionmentioning

confidence: 99%

“…coli and S. aureus strains . An oxygen self-supplying BODIPY compound was demonstrated to inhibit P.…”

Section: Introductionmentioning

confidence: 99%

Selenophene-Modified Boron Dipyrromethene-Based Photosensitizers Exhibit Photodynamic Inhibition on a Broad Range of Bacteria

et al. 2022

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Microorganisms are crucial for human survival in view of both mutualistic and pathogen interactions. The control of the balance could be achieved by use of the antibiotics. There is a continuous arms race that exists between the pathogen and the antibiotics. The emergence of multidrug-resistant (MDR) bacteria threatens health even for insignificant injuries. However, the discovery of new antibiotics is not a fast process, and the healthcare system will suffer if the evolution of MDR lingers in its current frequency. The cationic photosensitizers (PSs) provide a unique approach to develop novel, light-inducible antimicrobial drugs. Here, we examine the antimicrobial activity of innovative selenophene-modified boron dipyrromethene (BODIPY)-based PSs on a variety of Gram (+) and Gram (−) bacteria. The candidates demonstrate a level of confidence in both light-dependent and independent inhibition of bacterial growth. Among them, selenophene conjugated PS candidates (BOD-Se and BOD-Se-I) are promising agents to induce photodynamic inhibition (PDI) on all experimented bacteria: E. coli , S. aureus , B. cereus , and P. aeruginosa . Further characterizations revealed that photocleavage ability on DNA molecules could be potentially advantageous over extracellular DNA possessing biofilm-forming bacteria such as B. cereus and P. aeruginosa . Microscopy analysis with fluorescent BOD-H confirmed the colocalization on GFP expressing E. coli .

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“…The most studied and successfully applied PSs are porphyrin-based drugs. Recently, on the basis of experimental and theoretical studies [ 11 , 12 , 13 ], new compounds, belonging to the family widely known as boron dipyrromethenes (BODIPYs), were proposed as promising candidates for PDT due to their ability to generate singlet oxygen, high solubility in common organic solvents and very favourable chemical–physical properties [ 14 ]. Although BODIPYs, due to their remarkable fluorescence quantum yields, usually exhibit negligible triplet-state formation, their possible derivatization allows the fine modulation of the photophysical behaviour.…”

Section: Introductionmentioning

confidence: 99%

How Computations Can Assist the Rational Design of Drugs for Photodynamic Therapy: Photosensitizing Activity Assessment of a Ru(II)-BODIPY Assembly

et al. 2022

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Ruthenium-based complexes represent a new frontier in light-mediated therapeutic strategies against cancer. Here, a density functional-theory-based computational investigation, of the photophysical properties of a conjugate BODIPY-Ru(II) complex, is presented. Such a complex was reported to be a good photosensitizer for photodynamic therapy (PDT), successfully integrating the qualities of a NIR-absorbing distyryl-BODIPY dye and a PDT-active [Ru(bpy)3]2+ moiety. Therefore, the behaviour of the conjugate BODIPY-Ru(II) complex was compared with those of the metal-free BODIPY chromophore and the Ru(II) complex. Absorptions spectra, excitation energies of both singlet and triplet states as well as spin–orbit-matrix elements (SOCs) were used to rationalise the experimentally observed different activities of the three potential chromophores. The outcomes evidence a limited participation of the Ru moiety in the ISC processes that justifies the small SOCs obtained for the conjugate. A plausible explanation was provided combining the computational results with the experimental evidences.

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Optimizing the photodynamic therapeutic effect of BODIPY-based photosensitizers against cancer and bacterial cells

Cited by 12 publications

References 49 publications

Hydroxyapatite/L-Lysine Composite Coating as Glassy Carbon Electrode Modifier for the Analysis and Detection of Nile Blue A

Hydroxyapatite/L-Lysine Composite Coating as Glassy Carbon Electrode Modifier for the Analysis and Detection of Nile Blue A

Selenophene-Modified Boron Dipyrromethene-Based Photosensitizers Exhibit Photodynamic Inhibition on a Broad Range of Bacteria

How Computations Can Assist the Rational Design of Drugs for Photodynamic Therapy: Photosensitizing Activity Assessment of a Ru(II)-BODIPY Assembly

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