Optimizing the operation of a sequential-simulated moving-bed separation process using MINLP

Solving a dynamic separation problem using MINLP techniques

“…. , K. The number of components to be separated is denoted by C, and the number of columns with K. The parameters F , β j , β jl , u and D j are in more detail described in [6]. The estimates in [6] corresponding to a fructose-glucose mixture are presented in Table 1.…”

“…The fifth term is a so-called convection term and the RHS is a diffusion term. For more details about the chromatography and the assumptions that have to be made concerning the separation process, see [6].…”

“…The decisions in the model should be made in periods of τ , and hence the system should be in a so-called steady state condition [6]. Mathematically, the concentrations in a column should be equal at the start and at the end of a period:…”

“…The optimization of separation processes has been addressed in the pertinent literature, for example, in [9], [12] and in [2]. A chromatographic separation problem was modeled and solved as an MINLP problem by [6] and recently in [4]. Comparisons of solving the MINLP problem in [6] using alternative MINLP methods was carried out in [3].…”

“…A chromatographic separation problem was modeled and solved as an MINLP problem by [6] and recently in [4]. Comparisons of solving the MINLP problem in [6] using alternative MINLP methods was carried out in [3]. Fig.…”