Optimizing the Geometry of Photoacoustically Active Gold Nanoparticles for Biomedical Imaging

García-Álvarez, Rafaela; Chen, Lisa; Nedilko, Alexander; Sánchez‐Iglesias, Ana; Rix, Anne; Lederle, Wiltrud; Pathak, Vertika; Lammers, Twan; Plessen, G. von; Kostarelos, Kostas; Liz‐Marzán, Luis M.; Kuehne, Alexander J. C.; Chigrin, Dmitry N.

doi:10.1021/acsphotonics.9b01418

Cited by 54 publications

(50 citation statements)

References 31 publications

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“…7 Knowledge of the relative magnitude of scattering compared to absorption is critical to many gold nanoparticle applications. For example, particles that strongly absorb are required for photothermal therapies, [8][9][10][11][12][13] as well as for types of cell and tissue imaging including photoacoustic imaging, [14][15][16][17][18] whereas those that scatter strongly are useful in biological imaging such as optical coherence tomography. [19][20][21][22] A thorough understanding of the relative contributions of absorption and scattering for specic particles can indicate their usefulness in particular applications.…”

Section: Introductionmentioning

confidence: 99%

Mie theory and the dichroic effect for spherical gold nanoparticles: an experimental approach

Wrigglesworth

Johnston

2021

Nanoscale Adv.

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Section: Introductionmentioning

confidence: 99%

Mie theory and the dichroic effect for spherical gold nanoparticles: an experimental approach

Wrigglesworth

Johnston

2021

Nanoscale Adv.

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“…According to the recently published work, the absorption cross-section of the similar-sized solid AuNRs is about 1600 nm 2 and the relative absorption is about 80%. [42] Because their plasmonic absorption and the mass of a single particle are different from that of solid AuNRs, the real value of hollow AuNRs should be further studied. Even so, the hollow Au nanostructures possess higher photoacoustic efficacy and better plasmonic properties than the solid counterparts.…”

Section: Photothermal and Photoacoustic Property Of M-auhnrsmentioning

confidence: 99%

Miniature Hollow Gold Nanorods with Enhanced Effect for In Vivo Photoacoustic Imaging in the NIR‐II Window

Cai

Zhang

Foda

et al. 2020

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The miniaturization of gold nanorods exhibits a bright prospect for intravital photoacoustic imaging (PAI) and the hollow structure possesses a better plasmonic property. Herein, miniature hollow gold nanorods (M‐AuHNRs) (≈46 nm in length) possessing strong plasmonic absorbance in the second near‐infrared (NIR‐II) window (1000–1350 nm) are developed, which are considered as the most suitable range for the intravital PAI. The as‐prepared M‐AuHNRs exhibit 3.5 times stronger photoacoustic signal intensity than the large hollow Au nanorods (≈105 nm in length) at 0.2 optical density under 1064 nm laser irradiation. The in vivo biodistribution measurement shows that the accumulation in tumor of miniature nanorods is twofold as high as that of the large counterpart. After modifying with a tumor‐targeting molecule and fluorochrome, in living tumor‐bearing mice, the M‐AuHNRs group gives a high fluorescence intensity in tumors, which is 3.6‐fold that of the large ones with the same functionalization. Moreover, in the intravital PAI of living tumor‐bearing mice, the M‐AuHNRs generate longer‐lasting and stronger photoacoustic signal than the large counterpart in the NIR‐II window. Overall, this study presents the fabrication of M‐AuHNRs as a promising contrast agent for intravital PAI.

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“…Its use allows the early detection of tumors and other diseases, and guides precision treatment. Gold nanoparticles are well known for their ability to increase biological inactivity and spatial and temporal resolution for imaging ( Singh et al, 2018 ; García-Álvarez et al, 2020 ; Si et al, 2021 ; Qambrani et al, 2021 ).…”

Section: Biomedical Applications Of Hollow Gold Nanostructuresmentioning

confidence: 99%

Recent Advances in Hollow Gold Nanostructures for Biomedical Applications

et al. 2021

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The localized surface plasmon resonance of metallic nanoparticles has attracted much attention owing to its unique characteristics, including the enhancement of signals in sensors and photothermal effects. In particular, hollow gold nanostructures are highly promising for practical applications, with significant advantages being found in their material properties and structures: 1) the interaction between the outer surface plasmon mode and inner cavity mode leads to a greater resonance, allowing it to absorb near-infrared light, which can readily penetrate tissue; 2) it has anti-corrosiveness and good biocompatibility, which makes it suitable for biomedical applications; 3) it shows a reduced net density and large surface area, allowing the possibility of nanocarriers for drug delivery. In this review, we present information on the classification, characteristics, and synthetic methods of hollow gold nanostructures; discuss the recent advances in hollow gold nanostructures in biomedical applications, including biosensing, bioimaging, photothermal therapy, and drug delivery; and report on the existing challenges and prospects for hollow gold nanostructures.

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Optimizing the Geometry of Photoacoustically Active Gold Nanoparticles for Biomedical Imaging

Cited by 54 publications

References 31 publications

Mie theory and the dichroic effect for spherical gold nanoparticles: an experimental approach

Mie theory and the dichroic effect for spherical gold nanoparticles: an experimental approach

Miniature Hollow Gold Nanorods with Enhanced Effect for In Vivo Photoacoustic Imaging in the NIR‐II Window

Recent Advances in Hollow Gold Nanostructures for Biomedical Applications

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