Optimizing the blood component production process

Cid, Joan; Velasquez, Cole; Lozano, Miguel

doi:10.1111/voxs.12180

Cited by 3 publications

(3 citation statements)

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“…Other beneficial aspects of automating blood processing systems include improved standardization of outputs, increased productivity, operator satisfaction and system usability, reduced wastage and reductions in required space and operator skill requirements, as well as reduced potential for repetitive strain injury to operators [3,5,6,9,32]. In addition, reduction in the required space and the number of operators also decreases the movement of operators around the workspace, which could play a major role in preventing the spread of diseases such as COVID-19.…”

Section: Discussionmentioning

confidence: 99%

“…Other authors have also reported that full automation may contribute to a balance between standardization and customization. Also, the released resources would enable the effortless implementation of other technologies in the blood component laboratory [3,5,32]. In addition, standardization of semi-automated processing methods remains highly variable among centres, with the remaining manual steps continuing to impact wastage as well as the quality and safety of blood products [3,5].…”

Section: Discussionmentioning

confidence: 99%

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Comparison of automated versus semi‐automated whole blood processing systems: A systematic review

et al. 2023

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Background and Objectives Implementation of automated steps in preparing blood components for transfusion from whole blood collections has produced improvements in multiple fields. The aim of this review is to summarize data from existing literature related to automation of whole blood processing systems. Materials and Methods We searched MEDLINE for studies comparing semi‐automated and fully automated whole blood processing systems published before 20 July 2021. Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines were followed. Additionally, we performed a manual search. Results We identified 500 studies, of which 459 (92%) did not meet the eligibility criteria, and finally 17 studies were included in the analysis. Manual search included six additional studies. Publication year ranged from 2004 to 2021. Automation reduced the run‐time (from 92 to 76 min), improved recovery of haemoglobin in red cell concentrates (RCCs) and resulted in higher red blood cell and platelet yields. Automation also reduced discard rates due to whole blood bag ruptures (1.2%–0.1%), low volume of RCCs (<200 ml; 0.5%–0.03%) and haemolytic plasma (2.1%–0.6%). Automation could reduce the number of full‐time equivalent (FTE) operators or maintain the number of FTE operators while performing additional procedures, and it reduced to 1.13 m2 the space required for the device. Conclusion Automation of whole blood processing resulted in continued improvements in productivity, product quality and technical features. However, too few publications are available to reach strong conclusions. Therefore, it is necessary to expand the scientific knowledge in this field.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comparison of automated versus semi‐automated whole blood processing systems: A systematic review

et al. 2023

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“…A retrospective study analysing the impact on corrected 1‐h corrected count increment (CCI) and the transfusion interval did not find significant differences with the manual method . Subsequently, new generation of automation devices have been introduced in the marked which are reviewed elsewhere .…”

Section: Automation In Platelet Preparationmentioning

confidence: 99%

Recent advances in platelet processing and storage

Lozano¹,

Cid²

2016

ISBT Science Series

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Platelet rich plasma (PRP) method was the first method used for platelet concentrate (PC) preparation and continues to be the only licensed method in the USA. By contrast in Europe since the eighties of the last century, the PRP method has been progressively replaced by methods based on the removal of the buffy coat (BC) layer. Initially BC were processed individually to produced a single PC but it was soon recognized that the pooling of 4-6 BC units with the addition of a plasma unit of one of the donors of the pool or a platelet additive solution (PAS), improved the efficiency of the separation and eased the transfusion process since the final product was stored as an adult transfusion dose ready to be connected to the patient. Semi-automatic devices were developed for the separation of whole blood into red blood cells, plasma and the BC and for the separation of the BC into the PC. The introduction of PAS in combination with plasma (in general about 35% of plasma and 65% PAS) for storing PC has shown to offer advantages such as an increased availability of plasma for fractionation, a reduction of transfusion reactions to platelets and a potential reduction in the risk of transfusion related acute lung injury. While early generations of PAS were associated to a decrease in the post-transfusion corrected platelet count in comparison to PC stored in 100% plasma, this effect has not been found with the newer generation of PAS.

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