Optimizing surface characteristics for cell adhesion and proliferation on titanium plasma spray coatings on polyetheretherketone

Yoon, Byung Jo Victor; Xavier, Fred; Walker, Brendon; Grinberg, Samuel; Cammisa, Frank P.; Abjornson, Celeste

doi:10.1016/j.spinee.2016.05.017

Cited by 66 publications

(43 citation statements)

References 29 publications

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“…33 However, the application of PEEK has been limited by the formation of a biofilm layer around its surface that potentially affects fusion to cortical bone. 34 This limitation of PEEK could be avoided by the application of Ti which has a microscopic rough surface that increases osteogenic cell differentiation factors. To further explore the properties of Ti, several studies investigated PEEK interbody cages with electron beam coating of Ti onto the surfaces showing some benefits compared to PEEK alone.…”

Section: Discussionmentioning

confidence: 99%

Polyetheretherketone Versus Titanium Cages for Posterior Lumbar Interbody Fusion: Meta-Analysis and Review of the Literature

et al. 2020

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Objective: Lumbar fusion with implantation of interbody cage is a common procedure for treatment of lumbar degenerative disease. This study aims to compare the fusion and subsidence rates of titanium (Ti) versus polyetheretherketone (PEEK) interbody cages after posterior lumbar interbody fusion and investigate the effect of clinical and radiological outcomes following fusion on patient-reported outcomes. Methods: A systematic search strategy of 4 electronic databases (MEDLINE, Embase, Web of Science, and Cochrane) was conducted using different MeSH (medical subject headings) terms until January 2020. Pooled odds ratios (ORs) with 95% confidence intervals (CI) were calculated using fixed and random-effect models based upon the heterogeneity (I 2 ) to estimate the association between interbody cages and the measured outcomes. Results: A total of 1,094 patients from 11 studies were reviewed. The final analysis included 421 patients (38.5%) who had lumbar surgery using a Ti and/or a Ti-coated interbody cage and 673 patient (61.5%) who had lumbar surgery using a PEEK cage. Overall, PEEK interbody devices were associated with a significantly lower fusion rate compared with Ti interbody devices (OR, 0.62; 95% CI, 0.41-0.93; p = 0.02). There was no difference in subsidence rates between Ti and PEEK groups (OR, 0.91; 95% CI, 0.54-1.52; p = 0.71). Also, there were no statistically significant differences in visual analogue scale (VAS)-low back pain (p = 0.14) and Japanese Orthopedic Association scale (p = 0.86) between the 2 groups. However, the PEEK group had lower odds of leg pain after surgery compared to the Ti group (OR [VAS-leg], 0.61; 95% CI, 0.28-0.94; p = 0.003). Conclusion: Ti and Ti-coated PEEK cages used for posterior lumbar interbody fusion are associated with similar rates of subsidence, but a higher rate of fusion compared to PEEK interbody cages. Randomized controlled trials are needed to better assess the effect of cage materials and potential factors that could influence the outcomes of interbody lumbar fusion.

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Section: Discussionmentioning

confidence: 99%

Polyetheretherketone Versus Titanium Cages for Posterior Lumbar Interbody Fusion: Meta-Analysis and Review of the Literature

et al. 2020

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“…PEEK is recognized as a suitable implant material for hard tissue application because of its good mechanical properties, low density (ie, radiolucency), and good chemical resistance [14]. However, PEEK alone is chemically inert, forming a biofilm layer that inhibits binding to the host bone, which has limited its wider application [24]. Many studies have been conducted to overcome the limitations of PEEK; coating PEEK with a bioactive substance has been shown to be a very effective technique for enhancing the biocompatibility of PEEK while maintaining its other advantages [25][26][27][28].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of a polyetheretherketone (PEEK) titanium composite interbody spacer in an ovine lumbar interbody fusion model: biomechanical, microcomputed tomographic, and histologic analyses

et al. 2017

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“…On the cell level, structures in the nano‐ und micro‐range have a predominant impact on the biological response (Anselme et al, ). Favorable for adhesion of osteoblasts and mesenchymal stem cells are surfaces which are rough above the cell scale (>50 μm) but smooth at the cell scale (≤50 μm) presenting relatively flat areas that permit cell attachment (Bigerelle et al, ; Wu et al, ; Yoon et al, ). The nanoscale of surface topography is important for the adsorption of proteins and interaction with cellular structures and surface molecules which mediate the cell response to the implant surface (Ponche et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Favorable for adhesion of osteoblasts and mesenchymal stem cells are surfaces which are rough above the cell scale (>50 μm) but smooth at the cell scale (≤50 μm) presenting relatively flat areas that permit cell attachment (Bigerelle et al, 2002;Wu et al, 2011;Yoon et al, 2016).…”

Section: Histomorphometric Analysismentioning

confidence: 99%

Evaluation of topographical and chemical modified TiAl6V4 implant surfaces in a weight‐bearing intramedullary femur model in rabbit

et al. 2019

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For cementless total joint replacement implants, the biological response to physicochemical surface characteristics is crucial for their success that depends on fixation by newly formed bone. In this study, the surface of TiAl6V4 (Tilastan®) implants was modified by (a) corundum blasting, (b) corundum blasting followed by electrochemical calcium phosphate (CaP) deposition, and (c) titanium plasma spraying followed by electrochemical CaP deposition. All modifications resulted in a surface roughness suitable to enhance primary implant stabilization and to favor osteoblast adhesion and function; the thin, biomimetic CaP coating is characterized by fast resorbability and served as chemical cue to stimulate osteogenesis. After implantation in a full weight‐bearing rabbit intramedullary distal femur model, osseointegration was investigated after 3, 6, and 12 weeks. For all modifications, new bone formation, occurring from the endosteum of the femoral cortical bone, was observed in direct contact to the implant surface after 3 weeks. At the later time points, maturation of the woven bone into lamellar bone with clearly defined osteons was visible; the remodeling process was accelerated by the CaP coating. The ingrowth of newly formed bone into the pores of the titanium plasma sprayed surfaces indicates a strong interlock and finally implant fixation. Our findings indicate a positive impact of the tested surface modifications on osseointegration.

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Optimizing surface characteristics for cell adhesion and proliferation on titanium plasma spray coatings on polyetheretherketone

Cited by 66 publications

References 29 publications

Polyetheretherketone Versus Titanium Cages for Posterior Lumbar Interbody Fusion: Meta-Analysis and Review of the Literature

Polyetheretherketone Versus Titanium Cages for Posterior Lumbar Interbody Fusion: Meta-Analysis and Review of the Literature

Evaluation of a polyetheretherketone (PEEK) titanium composite interbody spacer in an ovine lumbar interbody fusion model: biomechanical, microcomputed tomographic, and histologic analyses

Evaluation of topographical and chemical modified TiAl6V4 implant surfaces in a weight‐bearing intramedullary femur model in rabbit

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