Optimizing proton pump inhibitor therapy for treatment of nonvariceal upper gastrointestinal bleeding

Worden, Jarett C.; Hanna, Kirollos S

doi:10.2146/ajhp151032

Cited by 15 publications

(11 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A study by Worden et al has shown that intermittent PPI therapy after endoscopy in higher-risk stigmata and oral PPI therapy in lower-risk patients are equally effective when compared to continuous PPI infusion in treating UGIB and this will help in reducing significant costs. Contrarily, a budget impact analysis done by Lu et al showed that the incremental costs of using different PPI regimens (continuous versus intermittent, duration) are modest (~$200) when compared to the total in-patient cost [16][17].…”

Section: Discussionmentioning

confidence: 99%

Outcomes of Upper Gastrointestinal Bleeding Based on Time to Endoscopy: A Retrospective Study

Saleem

Kudaravalli

Riaz

et al. 2020

Cureus

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Outcomes of Upper Gastrointestinal Bleeding Based on Time to Endoscopy: A Retrospective Study

Saleem

Kudaravalli

Riaz

et al. 2020

Cureus

View full text Add to dashboard Cite

“…Omeprazole is available in both oral and injectable forms (Worden and Hanna, 2017) and has few side effects (Schubert, 2017). Although less common, the injectable form is an effective means of gastric ulcer treatment and gastric acidification inhibition (Worden and Hanna, 2017).…”

Section: Discussionmentioning

confidence: 99%

Extra-gastric expression of the proton pump H+/K+ -ATPase in the gills and kidney of the teleost Oreochromis niloticus

Barnawi

Doherty

Ferreira

et al. 2020

Journal of Experimental Biology

View full text Add to dashboard Cite

Potassium regulation is essential for the proper functioning of excitable tissues in vertebrates. The H+/K+-ATPase (HKA), which is composed of the HKα1 (gene: atp4a) and HKβ (gene: atp4b) subunits, has an established role in potassium and acid–base regulation in mammals and is well known for its role in gastric acidification. However, the role of HKA in extra-gastric organs such as the gill and kidney is less clear, especially in fishes. In the present study in Nile tilapia, Oreochromis niloticus, uptake of the K+ surrogate flux marker rubidium (Rb+) was demonstrated in vivo; however, this uptake was not inhibited with omeprazole, a potent inhibitor of the gastric HKA. This contrasts with gill and kidney ex vivo preparations, where tissue Rb+ uptake was significantly inhibited by omeprazole and SCH28080, another gastric HKA inhibitor. The cellular localization of this pump in both the gill and kidney was demonstrated using immunohistochemical techniques with custom-made antibodies specific for Atp4a and Atp4b. Antibodies against the two subunits showed the same apical ionocyte distribution pattern in the gill and collecting tubules/ducts in the kidney. Atp4a antibody specificity was confirmed by western blotting. RT-PCT was used to confirm the expression of both subunits in the gill and kidney. Taken together, these results indicate for the first time K+ (Rb+) uptake in O. niloticus and that HKA is implicated, as shown through the ex vivo uptake inhibition by omeprazole and SCH28080, verifying a role for HKA in K+ absorption in the gill's ionocytes and collecting tubule/duct segments of the kidney.

show abstract

“…Hal ini masih menjadi perdebatan, manakah yang lebih superior untuk mengatasi perdarahan saluran cerna akut (Gambar 6). 14,15 Gambar 6. Algoritma Tatalaksana Perdarahan GIT selama terapi ACS Pada pasien yang mengalami perdarahan saluran cerna yang mendapat terapi antiplatelet, hemostasis endoskopi merupakan pilihan yang direkomendasikan untuk mengurangi angka morbiditas dan mortalitas.…”

Section: Vol 41 No 3 2018 Pendahuluanunclassified

Perdarahan saluran cerna setelah dilakukan intervensi koroner perkutan: suatu keputusan terapi yang sulit

Putra¹,

Fadil

Ilhami

2018

Maj Kedokt Andalas

View full text Add to dashboard Cite

Intervensi koroner perkutan merupakan prosedur invasif jantung yang sering dilakukan untuk mengobati pasien dengan penyakit arteri koroner. Komplikasi yang menakutkan seperti diseksi koroner atau penyumbatan koroner akut pada era balon angioplasti telah banyak berkurang dengan ditemukannya stent arteri koroner dan penggunaan rutin terapi antiplatelet dan antitrombotik. Peningkatan penggunaan DAPT tersebut meningkatkan risiko pasien untuk terjadinya cedera saluran cerna dan perdarahan. Mengobati pasien yang mengalami perdarahan setelah IKP merupakan suatu hal yang rumit, karena kita harus mempertimbangkan intervensi yang tepat untuk mengelola perdarahan aktif, untuk menimbang manfaat potensial untuk meneruskan atau menghentikan terapi antiplatelet dan untuk mengevaluasi apakah diperlukan transfusi sel darah merah yang bisa menimbulkan efek samping yang merugikan. Pemberian PPI direkomendasikan oleh panduan Amerika dan Eropa untuk terapi yang bisa diberikan pada perdarahan saluran cerna akibat pemberian antiplatelet dan hemostasis endoskopi merupakan pilihan yang direkomendasikan untuk mengurangi angka morbiditas dan mortalitas.

show abstract

Optimizing proton pump inhibitor therapy for treatment of nonvariceal upper gastrointestinal bleeding

Abstract: Current guidelines recommend that PPIs be given as an i.v. bolus injection followed by a continuous infusion, but intermittent i.v. dosing and oral PPI therapy have been found to be effective in treating patients with UGIB and associated with reductions in cost.

Cited by 15 publications

References 32 publications

Outcomes of Upper Gastrointestinal Bleeding Based on Time to Endoscopy: A Retrospective Study

Outcomes of Upper Gastrointestinal Bleeding Based on Time to Endoscopy: A Retrospective Study

Extra-gastric expression of the proton pump H+/K+ -ATPase in the gills and kidney of the teleost Oreochromis niloticus

Perdarahan saluran cerna setelah dilakukan intervensi koroner perkutan: suatu keputusan terapi yang sulit

Contact Info

Product

Resources

About