Optimizing Narrowband UVB Phototherapy Regimens for Psoriasis

Yanovsky, Rebecca L.; Huang, Kathie P.; Buzney, Elizabeth A.

doi:10.1016/j.det.2019.08.001

Cited by 11 publications

(15 citation statements)

References 44 publications

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“…21 Phototherapy is a treatment option for patients with psoriasis and an effective first-line therapy for generalized plaque psoriasis. 22 There are several types of phototherapy: narrowband ultraviolet B (NB-UVB); broadband ultraviolet B (BB-UVB); and psoralen ultraviolet A photochemotherapy (oral or bath PUVA), NB-UVB being the most used for psoriasis. 23 The beneficial effect on psoriasis lesions is explained by the inhibition of epidermal hyperproliferation and its immunomodulatory effect.…”

Section: Introductionmentioning

confidence: 99%

Epidermal barrier changes in patients with psoriasis: The role of phototherapy

Montero‐Vílchez

Soler-Góngora

Martínez-López

et al. 2021

Photoderm Photoimm Photomed

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Background: Some skin diseases may modify epidermal barrier function. Psoriasis is a chronic multi-systemic inflammatory disease that affects the epidermal barrier.Phototherapy is an option for treating psoriasis, but little is known about how epidermal barrier function is modified by phototherapy in psoriatic patients. Objectives: (a) To compare skin homeostasis between involved and uninvolved skin in psoriatic patients with healthy controls (b) To evaluate changes in the epidermal barrier function in psoriatic patients treated with phototherapy.Methods: Sixty patients with plaque-type psoriasis and sixty gender and agematched healthy controls were enrolled. Temperature, transepidermal water loss (TEWL), stratum corneum hydration (SCH), pH, elasticity, erythema and melanin index were measured using non-invasive tools in the healthy control and involved and uninvolved psoriatic skin before and after phototherapy.Results: Healthy controls had lower TEWL and erythema index and higher SCH than psoriatic patients, both at uninvolved psoriatic skin and psoriasis plaques. TEWL was higher at psoriasis plaques than at uninvolved skin (19.20 vs 11.57 g/h/m 2 ; P < .001).Following phototherapy, a decreasing trend was observed for TEWL, of 1.03 (SD 0.75) and 0.97 (SD 0.81) g/h/m 2 for uninvolved and involved skin respectively. SCH was significantly lower at psoriatic plaques than at uninvolved skin (7.32 vs 36.62Arbitrary Units [AU]; P < .001). SCH increased by 1.15AU (SD 0.26) on psoriatic plaques after the phototherapy session (P < .001). Conclusion:Psoriatic plaques showed epidermal barrier dysfunction compared to uninvolved skin and healthy controls. Phototherapy may improve epidermal barrier function in psoriatic patients. SCH increased after a phototherapy session on the psoriatic plaques.

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Section: Introductionmentioning

confidence: 99%

Epidermal barrier changes in patients with psoriasis: The role of phototherapy

Montero‐Vílchez

Soler-Góngora

Martínez-López

et al. 2021

Photoderm Photoimm Photomed

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“…Several studies have demonstrated its effectiveness in treating psoriasis patients who have moderate to severe conditions (Lapolla, Yentzer, Bagel, Halvorson, & Feldman, 2011;Zhang & Wu, 2018). NB-UVB is an effective first-line treatment for generalized plaque psoriasis (Yanovsky, Huang, & Buzney, 2020). However, the biological process by which NB-UVB improves psoriasis is still under investigations.…”

Section: Discussionmentioning

confidence: 99%

Narrow band ultraviolet B therapy deactivates Th1/Th17 pathway and activates Th2 cytokines secretion in Egyptian psoriatic arthritis patients

Farid

Tawfik

Elsioufy

et al. 2020

Journal of Radiation Research and Applied Sciences

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“…Although the use of NB‐UVB was contraindicated in SLE previously, current guidelines recommend that it can be used with caution in these patients on the condition that there is no history of photosensitivity and anti‐Ro/SSA testing is negative. Moreover, these guidelines report that administration of NB‐UVB therapy is safe in patients who are taking photosensitizing medications 7 . Consequently, ANA testing is not currently recommended prior to initiating NB‐UVB phototherapy unless there is a suspicion of autoimmunity 16 .…”

Section: Discussionmentioning

confidence: 99%

“…A complete physical examination is recommended to ensure there are no obvious signs of other underlying diseases, especially photosensitive disorders that may be exacerbated due to exposure to ultraviolet (UV) radiation. Preliminary laboratory investigations including complete blood cell count, blood sugar, liver, and renal function tests can be performed 6,7 . However, screening of antinuclear antibody (ANA) status before phototherapy is a controversial topic.…”

Section: Introduction and Objectivesmentioning

confidence: 99%