Optimizing LINAC-based stereotactic radiotherapy of uveal melanomas: 7 years’ clinical experience

Options of Irradiating Intraocular Melanoma at Linear Accelerator: A Mini Review

“…Enucleation is not so frequent; there are other options such as block-excision, endoresection or radiotherapy which includes brachytherapy, Leksell Gama Knife, stereotactic irradiation, proton beam irradiation, and others [10][11][12]. The efficacy of LSRS for uveal melanoma is described in different studies where the local tumor control rates are over 90% [13][14][15].…”

Proton or Stereotactic Photon Irradiation for Posterior Uveal Melanoma?

“…Fovea centralis and even the optic disk, which may be positioned eccentric to the optic nerve, are not visible on CT and MRI, and thus they cannot routinely be taken into account in SRT planning, leaving dose deposition to them unaddressed although they are the factors most critical in preserving vision [2,5,13,21]. By the methods employed, we were able to use these anatomic areas and tailor SRT to reduce the probability of side effects to them.…”

“…Uveal melanoma is a very rare malignant tumor with an estimated incidence of only 0.6-0.8 per 100,000 per annum in Western Europe [5]. Radiation therapy nowadays is one of the cornerstones of therapy.…”

“…It was therefore not unexpected to find these modalities expanding their field of interest into ocular radiation therapy [4,18]. Although compelling results in regard of tumor control have been reported in some series, others where rather disappointing [5,23].…”

Stereotactic Photon Beam Irradiation of Uveal Melanoma: Indications and Experience at the University of Vienna since 1997

“…Since 1997, at the Medical University of Vienna, patients with uveal melanoma have been treated with 3D stereotactic photon beam radiotherapy. Special fixation-and eye-monitoring systems have been developed to perform a local treatment which provides high local tumor control with acceptable long term side effects [6,7].…”