Optimizing fibromyalgia management

Firestone, Kari A.; Holton, Kathleen F.; Mist, Scott D.; Wright, Cheryl L.; Jones, Kim Dupree

doi:10.1097/01.npr.0000412891.19933.48

Cited by 7 publications

(2 citation statements)

References 46 publications

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“…114 Milnacipran has been demonstrated to improve transmission in the descending pain pathways, reducing pain intensity and stiffness and enhancing function. 115 We utilized 50 mg of tramadol, 100 mg of gabapentin every night, 30 mg of duloxetine twice a day, and ketorolac as needed to treat pain in a clinical trial. The patients who are suffering from COVID-19” pain crisis” had resolved by week 4, but still had acute pain scored as 4-6/10.…”

Section: Discussionmentioning

confidence: 99%

Molecular Biomarker Identification Using a Network-Based Bioinformatics Approach That Links COVID-19 With Smoking

Rahman

Amin

Yeasmin

et al. 2023

Bioinform Biol Insights

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The COVID-19 coronavirus, which primarily affects the lungs, is the source of the disease known as SARS-CoV-2. According to “Smoking and COVID-19: a scoping review,” about 32% of smokers had a severe case of COVID-19 pneumonia at their admission time and 15% of non-smokers had this case of COVID-19 pneumonia. We were able to determine which genes were expressed differently in each group by comparing the expression of gene transcriptomic datasets of COVID-19 patients, smokers, and healthy controls. In all, 37 dysregulated genes are common in COVID-19 patients and smokers, according to our analysis. We have applied all important methods namely protein-protein interaction, hub-protein interaction, drug-protein interaction, tf-gene interaction, and gene-MiRNA interaction of bioinformatics to analyze to understand deeply the connection between both smoking and COVID-19 severity. We have also analyzed Pathways and Gene Ontology where 5 significant signaling pathways were validated with previous literature. Also, we verified 7 hub-proteins, and finally, we validated a total of 7 drugs with the previous study.

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Section: Discussionmentioning

confidence: 99%

Molecular Biomarker Identification Using a Network-Based Bioinformatics Approach That Links COVID-19 With Smoking

Rahman

Amin

Yeasmin

et al. 2023

Bioinform Biol Insights

View full text Add to dashboard Cite

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“…1,2 Onset of symptoms is typically in the age range of 30-40 years, and often results in limitations in physical function and daily activities, severely impacting patients' quality of life. 3,4 FM affects between 2% and 6% of the US adult population and is associated with a significant economic burden on health care systems, patients with FM, and their families. [5][6][7] The lack of widespread understanding of FM symptoms, coupled with an overlap of these symptoms with other conditions such as chronic fatigue syndrome, depression, anxiety, and irritable bowel syndrome, means that FM can be challenging to diagnose and treat.…”

Section: Introductionmentioning

confidence: 99%

Living with fibromyalgia: results from the functioning with fibro survey highlight patients' experiences and relationships with health care providers

Malik¹,

Masters²,

Clair³

et al. 2015

NRR

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Fibromyalgia (FM) is a chronic disorder characterized by widespread pain, which can limit patients' physical function and daily activities. FM can be challenging to treat, and the treatment approach could benefit from a greater understanding of patients' perspectives on their condition and their care. Patients with FM participated in an online survey conducted in the USA that sought to identify the symptoms that had the greatest impact on patients' daily lives. The purpose of the survey was to facilitate efforts toward improving care of patients by nurse practitioners, primary care providers, and specialists, in addition to contributing to the development of new outcome measures in both clinical trials and general practice. A total of 1,228 patients with FM completed the survey, responding to specific questions pertaining to symptoms, impact of symptoms, management of FM, and the relationship with health care providers. Chronic pain was identified as the key FM symptom, affecting personal and professional relationships, and restricting physical activity, work, and social commitments. Patients felt that the severity of their condition was underestimated by family, friends, and health care providers. The results of this survey highlight the need for nurse practitioners, primary care providers, and specialists to provide understanding and support to patients as they work together to enable effective diagnosis and management of FM.

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Fibromyalgia: Disease Synopsis, Medication Cost Effectiveness and Economic Burden

Skaer

2014

PharmacoEconomics

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Fibromyalgia (FM) primarily affects women, and it is increasingly recognized by health care providers as more patients seek assistance for their chronic pain conditions. FM patients suffer from reduced quality of life, daily functioning and productivity. A single FM patient can cost society tens of thousands of dollars each year, with the overall expense increasing alongside disease severity. Indirect costs account for the majority of total expenditures and involve losses in productivity, reduced work hours, absenteeism, disability, unemployment, early retirement, informal care and other out-of-pocket costs. Health care utilization increases in concert with the severity of illness. Moreover, FM patients often have several comorbid illnesses (e.g. depression, anxiety and sleep disturbances), resulting in extreme escalation of overall health care expenditures. Medications with the best efficacy in the treatment of FM include the tricyclic antidepressants amitriptyline and nortriptyline, cyclobenzaprine (a skeletal muscle relaxant), tramadol, duloxetine, milnacipran, pregabalin and gabapentin. Corticosteroids, nonsteroidal anti-inflammatory drugs, benzodiazepines and opioid analgesics, with the exception of tramadol, are not considered efficacious. Medication selection should be individualized and influenced by the severity of illness and the presence of comorbidities and functional disabilities.

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Optimizing fibromyalgia management

Cited by 7 publications

References 46 publications

Molecular Biomarker Identification Using a Network-Based Bioinformatics Approach That Links COVID-19 With Smoking

Molecular Biomarker Identification Using a Network-Based Bioinformatics Approach That Links COVID-19 With Smoking

Living with fibromyalgia: results from the functioning with fibro survey highlight patients' experiences and relationships with health care providers

Fibromyalgia: Disease Synopsis, Medication Cost Effectiveness and Economic Burden

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Optimizing fibromyalgia management

Cited by 7 publications

References 46 publications

Molecular Biomarker Identification Using a Network-Based Bioinformatics Approach That Links COVID-19 With Smoking

Molecular Biomarker Identification Using a Network-Based Bioinformatics Approach That Links COVID-19 With Smoking

Living with fibromyalgia: results from the functioning with fibro survey highlight patients&#39; experiences and relationships with health care providers

Fibromyalgia: Disease Synopsis, Medication Cost Effectiveness and Economic Burden

Contact Info

Product

Resources

About

Living with fibromyalgia: results from the functioning with fibro survey highlight patients' experiences and relationships with health care providers