2019
DOI: 10.1093/jac/dkz265
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Optimizing ethambutol dosing among HIV/tuberculosis co-infected patients: a population pharmacokinetic modelling and simulation study

Abstract: Background Reduced ethambutol serum concentrations are commonly observed among TB patients co-infected with HIV and may lead to treatment failure. Objectives To perform a population pharmacokinetic study of ethambutol in HIV/TB patients, and to evaluate an intensified ethambutol weight-based dosing strategy to support pharmacokinetic target attainment. Methods … Show more

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Cited by 8 publications
(25 citation statements)
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“…A two-compartment model with creatinine clearance and total body weight included as covariates best described the pharmacokinetics of ethambutol for the patients enrolled in the present study, and this is supported by previously published studies [ 15 , 19 ]. The differences between the primary pharmacokinetic parameters of ICU and outpatients were all statistically significant (as reported in Table 3 ).…”
Section: Discussionsupporting
confidence: 82%
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“…A two-compartment model with creatinine clearance and total body weight included as covariates best described the pharmacokinetics of ethambutol for the patients enrolled in the present study, and this is supported by previously published studies [ 15 , 19 ]. The differences between the primary pharmacokinetic parameters of ICU and outpatients were all statistically significant (as reported in Table 3 ).…”
Section: Discussionsupporting
confidence: 82%
“…In our study, the volume of the peripheral compartment in ICU patients is similar to the outpatients. There has been a wide range of volumes of the peripheral compartment reported in outpatients (typical values of 16.5 (bioavailability fixed to 1) to 512 (bioavailability fixed to 0.65) [ 15 , 19 ]), and the results of our study fit within these results.…”
Section: Discussionsupporting
confidence: 80%
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