Optimizing environmental enrichment for Sprague Dawley rats: Exemplary insights into the liver proteome
Nathalie N. Roschke,
Karl H. Hillebrandt,
Dietrich Polenz
et al.
Abstract:Background
Considering the expected increase in the elderly population and the growing emphasis on aging-related biomedical research, the demand for aged laboratory animals has surged, challenging established husbandry practices. Our objective was to establish a cost-effective method for environmental enrichment, utilizing the liver as a representative organ to assess potential metabolic changes in response to differing enrichment levels.
Methods
We conducted a six-month study involving 24 male Sprague Dawle… Show more
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