Optimizing drug discovery: Surface plasmon resonance techniques and their multifaceted applications

Acharya, Biswajeet; Behera, Amulyaratna; Behera, Suchismeeta

doi:10.1016/j.chphi.2023.100414

Cited by 16 publications

(8 citation statements)

References 169 publications

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“…𝑅 is the maximum SPR signal at saturation of the reactant; 𝑑𝑅 𝑑𝑡 is the derivative of the SPR signal with respect to time t, which is the rate at which antigen molecules fixed on the surface of the sensing chip combine with antibodies to form complexes; 𝑐 is the mass concentration of the analyte; 𝑘 and 𝑘 are binding constants and dissociation constants, respectively. Calculated results: 𝑘 1.33 × 10 M • s ; 𝑘 7.47 × 10 s , and the molecular affinity constant can be calculated from 𝐾 𝑘 𝑘 5.62 × 10 M. The above calculation results are comparable to those reported in the other literature [42,43], demonstrating the system's capability for biomolecular dynamic analysis.…”

Section: 𝐿𝑂𝐷 × 𝜎supporting

confidence: 78%

Wavelength Division Multiplexing-Based High-Sensitivity Surface Plasmon Resonance Imaging Biosensor for High-Throughput Real-Time Molecular Interaction Analysis

Niu,

Du,

et al. 2024

Molecules

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In this study, we report the successful development of a novel high-sensitivity intensity-based Surface Plasmon Resonance imaging (SPRi) biosensor and its application for detecting molecular interactions. By optimizing the excitation wavelength and employing a wavelength division multiplexing (WDM) algorithm, the system can determine the optimal excitation wavelength based on the initial refractive index of the sample without adjusting the incidence angle. The experimental results demonstrate that the refractive index resolution of the system reaches 1.77×10−6 RIU. Moreover, it can obtain the optimal excitation wavelength for samples with an initial refractive index in the range of 1.333 to 1.370 RIU and accurately monitor variations within the range of 0.0037 RIU without adjusting the incidence angle. Additionally, our new SPRi technique realized real-time detection of high-throughput biomolecular binding processes, enabling analysis of kinetic parameters. This research is expected to advance the development of more accurate SPRi technologies for molecular interaction analysis.

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Section: 𝐿𝑂𝐷 × 𝜎supporting

confidence: 78%

Wavelength Division Multiplexing-Based High-Sensitivity Surface Plasmon Resonance Imaging Biosensor for High-Throughput Real-Time Molecular Interaction Analysis

Niu,

Du,

et al. 2024

Molecules

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“…Initially, the light beam is directed toward the SPR coupler to stimulate the oscillation of electrons on the metal surface (surface plasmons). Interactions of light with these surface plasmons result in a dip in the intensity of reflected light . Subsequently, the detector captures the diffracted or reflected light.…”

Section: Rapid Cortisol Technologiesmentioning

confidence: 99%

“…Interactions of light with these surface plasmons result in a dip in the intensity of reflected light. 82 Subsequently, the detector captures the diffracted or reflected light. A small change in refractive index at the interface of the metal-dielectric induces a corresponding modification in the effective index of the surface plasmon.…”

Section: Rapid Cortisol Technologiesmentioning

confidence: 99%

Advancements in Cortisol Detection: From Conventional Methods to Next-Generation Technologies for Enhanced Hormone Monitoring

Vignesh,

Castro-Dominguez,

James

et al. 2024

ACS Sens.

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The hormone cortisol, released as the end-product of the hypothalamic-pituitary-adrenal (HPA) axis, has a wellcharacterized circadian rhythm that enables an allostatic response to external stressors. When the pattern of secretion is disrupted, cortisol levels are chronically elevated, contributing to diseases such as heart attacks, strokes, mental health disorders, and diabetes. The diagnosis of chronic stress and stress related disorders depends upon accurate measurement of cortisol levels; currently, it is quantified using mass spectroscopy or immunoassay, in specialized laboratories with trained personnel. However, these methods are time-consuming, expensive and are unable to capture the dynamic biorhythm of the hormone. This critical review traces the path of cortisol detection from traditional laboratory-based methods to decentralised cortisol monitoring biosensors. A complete picture of cortisol biology and pathophysiology is provided, and the importance of precision medicine style monitoring of cortisol is highlighted. Antibody-based immunoassays still dominate the pipeline of development of point-of-care biosensors; new capture molecules such as aptamers and molecularly imprinted polymers (MIPs) combined with technologies such as microfluidics, wearable electronics, and quantum dots offer improvements to limit of detection (LoD), specificity, and a shift toward rapid or continuous measurements. While a variety of different sensors and devices have been proposed, there still exists a need to produce quantitative tests for cortisol � using either rapid or continuous monitoring devices that can enable a personalized medicine approach to stress management. This can be addressed by synergistic combinations of technologies that can leverage low sample volumes, relevant limit of detection and rapid testing time, to better account for cortisol's shifting biorhythm. Trends in cortisol diagnostics toward rapid and continuous monitoring of hormones are highlighted, along with insights into choice of sample matrix.

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“…6 Nanomedicine offers the potential to revolutionize treatment options by delivering drugs directly to affected cells or tissues, improving therapeutic outcomes, and reducing systemic toxicity. Additionally, ongoing research is exploring the use of nanomaterials for diagnostic purposes, such as imaging and sensing techniques, 7 further expanding their potential in the field of medicine. 8 Nanotechnology holds promise to treat many chronic diseases, which include cardiovascular, 9 neurological, 10 gastrointestinal, 11 autoimmune inflammatory, 12 infectious, 13 and reproductive diseases, 14 as well as various types of cancer.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Nanotechnology-Based Drug Delivery Systems for the Diagnosis and Treatment of Reproductive Disorders

Acharya,

Behera,

Behera

et al. 2024

ACS Appl. Bio Mater.

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Over the past decade, nanotechnology has seen extensive integration into biomedical applications, playing a crucial role in biodetection, drug delivery, and diagnostic imaging. This is especially important in reproductive health care, which has become an emerging and significant area of research. Global concerns have intensified around disorders such as infertility, endometriosis, ectopic pregnancy, erectile dysfunction, benign prostate hyperplasia, sexually transmitted infections, and reproductive cancers. Nanotechnology presents promising solutions to address these concerns by introducing innovative tools and techniques, facilitating early detection, targeted drug delivery, and improved imaging capabilities. Through the utilization of nanoscale materials and devices, researchers can craft treatments that are not only more precise but also more effective, significantly enhancing outcomes in reproductive healthcare. Looking forward, the future of nanotechnology in reproductive medicine holds immense potential for reshaping diagnostics, personalized therapies, and fertility preservation. The utilization of nanotechnology-driven drug delivery systems is anticipated to elevate treatment effectiveness, minimize side effects, and offer patients therapies that are not only more precise but also more efficient. This review aims to delve into the various types, properties, and preparation techniques of nanocarriers specifically designed for drug delivery in the context of reproductive disorders, shedding light on the current landscape and potential future directions in this dynamic field.

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Optimizing drug discovery: Surface plasmon resonance techniques and their multifaceted applications

Cited by 16 publications

References 169 publications

Wavelength Division Multiplexing-Based High-Sensitivity Surface Plasmon Resonance Imaging Biosensor for High-Throughput Real-Time Molecular Interaction Analysis

Wavelength Division Multiplexing-Based High-Sensitivity Surface Plasmon Resonance Imaging Biosensor for High-Throughput Real-Time Molecular Interaction Analysis

Advancements in Cortisol Detection: From Conventional Methods to Next-Generation Technologies for Enhanced Hormone Monitoring

Recent Advances in Nanotechnology-Based Drug Delivery Systems for the Diagnosis and Treatment of Reproductive Disorders

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