Optimizing clinico-genomic disease prediction across ancestries: a machine learning strategy with Pareto improvement
Yan Gao,
Yan Cui
Abstract:Background
Accurate prediction of an individual’s predisposition to diseases is vital for preventive medicine and early intervention. Various statistical and machine learning models have been developed for disease prediction using clinico-genomic data. However, the accuracy of clinico-genomic prediction of diseases may vary significantly across ancestry groups due to their unequal representation in clinical genomic datasets.
Methods
We introduced a… Show more
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