2019
DOI: 10.5435/jaaos-d-18-00305
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Optimizing Clinical Use of Biologics in Orthopaedic Surgery: Consensus Recommendations From the 2018 AAOS/NIH U-13 Conference

Abstract: Concern that misinformation from direct-to-consumer marketing of largely unproven “biologic” treatments such as platelet-rich plasma and cell-based therapies may erode the public trust and the responsible investment needed to bring legitimate biological therapies to patients have resulted in calls to action from professional organizations and governing bodies. In response to substantial patient demand for biologic treatment of orthopaedic conditions, the American Academy of Orthopaedic Surgeons convened a coll… Show more

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Cited by 131 publications
(60 citation statements)
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“…A recent multicenter study showed that differences in manufacturing affect the characteristics and functions of human bone marrow stromal cells [39]. In that context, our approach meets the consensus recommendation of the AAOS/NIH for minimally manipulated autologous cell preparations (MMACP) [40].…”
Section: Discussionmentioning
confidence: 70%
“…A recent multicenter study showed that differences in manufacturing affect the characteristics and functions of human bone marrow stromal cells [39]. In that context, our approach meets the consensus recommendation of the AAOS/NIH for minimally manipulated autologous cell preparations (MMACP) [40].…”
Section: Discussionmentioning
confidence: 70%
“…With no insurance coverage for "stem cell" injection, centers that offer these injection therapies charge patients directly out-of-pocket, and engage in direct marketing to patients [11]. Therefore, awareness is required to address ethical approaches to these treatments in an attempt to aid responsible investment needed to bring legitimate biological therapies to patients [6,7].…”
Section: Discussionmentioning
confidence: 99%
“…Substantial differences in the content of platelets concentrates produced by the various automated and manual protocols have been described [12,13] and their consequences on clinical results in PRP therapy is currently being investigated [14,15]. Thus, the initiation of PRP injection activity within a hospital necessitates the selection of dedicated material and the establishment of a precise patient care procedure which should take into account recent recommendations from the AAOS regarding minimum reporting standards for clinical studies evaluating PRP [16].…”
Section: Introductionmentioning
confidence: 99%