Optimizing Automated Brain Extraction for Moderate to Severe Traumatic Brain Injury Patients: The Role of Intensity Normalization and Bias-Field Correction
Patrick Carbone,
Celina Alba,
Alexis Bennett
et al.
Abstract:Accurate brain extraction is crucial for the validity of MRI analyses, particularly in the context of traumatic brain injury (TBI), where conventional automated methods frequently fall short. This study investigates the interplay between intensity normalization, bias-field correction (also called intensity inhomogeneity correction), and automated brain extraction in MRIs of individuals with TBI. We analyzed 125 T1-weighted Magnetization-Prepared Rapid Gradient-Echo (T1-MPRAGE) and 72 T2-weighted Fluid-Attenuat… Show more
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