The management of emergency services within hospitals typically requires an effective manipulation and capitalization of data sources comprising worth information useful for hospitals' security, safety and efficiency. To meet these requirements, we dispose an agile approach of decision-making that addresses massive crowds occurring at the emergency departments. This approach considers the major constraints that might face these departments, as such lacks of human resources, high costs, and confusedness of patient's prioritization cases, non-sufficient capacity and logistics. We, basically, inspired from the biological immune defence processes to illustrate a piloting emergency mean known as the artificial immune system (AIS). This system intelligently assists hospital's decisionmakers to enhance their supplying strategies, provides relevant traces from tracking previous information that assist hospital's staffs that face the massive patient flow, and fosters the execution of efficient solutions. This paper investigates AIS data and relevant traces of overcrowding dilemmas, in which these data could be exploited to increase the reception planning, decrease tension-related anomalies within the emergency department, and supplying hospital chiefs working under stress. The main objective is to present the basic concepts of a new approach that aims to provide hospital decision-makers with relevant traces to assist them in their decision-making in the difficult situations. The expected benefits (main findings) for using the considered approach are not only to provide crisis managers with a relevant computerized decision support system, but also to minimize financial costs, reduce the response time and positively impact the crisis management.