Optimizing acupuncture treatment for dry eye syndrome: a systematic review

Kim, Bong Hyun; Kim, Min Hee; Kang, Se Hyun; Nam, Hae Jeong

doi:10.1186/s12906-018-2202-0

Cited by 94 publications

(55 citation statements)

References 26 publications

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“…The purpose of the present systematic review and meta-analysis was to analyze the difference between each acupuncture modality group (periocular acupoints group and periocular acupoints plus body acupoints group) and the AT group. Although previous systematic reviews and meta-analyses have confirmed that acupuncture may effectively relieve DED (26)(27)(28), to the best of our knowledge, the present study was the first systematic review evaluating the therapeutic effects of multi-acupoint acupuncture on DED. In comparison with previous studies, stricter inclusion and exclusion criteria were adopted.…”

Section: Discussionmentioning

confidence: 79%

“…A large number of randomized controlled trials (RCTs) and systematic reviews have indicated that acupuncture is effective in the treatment of various conditions, including vomiting, dental pain, chronic pain, lower back pain and eye disease (22)(23)(24)(25). In addition, several systematic reviews have confirmed that acupuncture is effective for DED (26)(27)(28). Lee et al (26) reported that the effect of acupuncture on dry eye was better than that of artificial tears (AT) as indicated by the results of Schirmer's I test (SIT), tear break up time (BUT) test, response rate and corneal fluorescein staining (CFS).…”

Section: Introductionmentioning

confidence: 99%

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Acupoint selection for the treatment of dry eye: A systematic review and meta‑analysis of randomized controlled trials

et al. 2020

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The effectiveness of acupuncture in the treatment of dry eye has been confirmed, but the association between acupoint selection and therapeutic effect has remained to be elucidated. In the present study, a systematic review and meta-analysis were performed to evaluate the effect of periocular acupoints and periocular acupoints plus body acupoints compared with AT for the treatment of dry eye disease (DED). The PubMed, Cochrane Library, Embase, Ovid, China National Knowledge Infrastructure and Chonqing VIP Information, Co., Ltd. databases were searched with entries until 10 July 2018 considered. Only randomized controlled trials (RCTs) were included. Meta-analyses were performed to compare the effects of acupuncture with those of conventional treatment (including AT or other non-acupuncture therapies). The primary outcomes, including tear break-up time (BUT), Schirmer's I test (SIT) result and Symptom scores were analyzed. Subgroup analysis was performed for periocular acupoints only and periocular acupoints plus body acupoints. A total of 12 studies comprising 900 participants were included. In the primary meta-analysis, a significant improvement in the BUT [n=1,209, weighted mean difference (WMD)=1.01, 95% CI: 0.56-1.84, P<0.00001], SIT result (n=1,107, WMD=1.98, 95% CI: 0.44-3.34, P<0.00001) and Symptom scores (n=402, WMD=-1.02, 95% CI:-1.33 to-0.72, P<0.00001) was obtained to evaluate the clinical efficacy of acupuncture and AT. Furthermore, periocular acupoints plus body acupoints were more effective in the treatment of DED. However, the total sample size of subjects with only periocular acupoints in the treatment of DED was too small to get any firm conclusions. Further large RCTs are warranted.

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Section: Discussionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Acupoint selection for the treatment of dry eye: A systematic review and meta‑analysis of randomized controlled trials

et al. 2020

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“…Acupuncture is a traditional medicine technique, not only an alternative medicinal technique but also one of the most popular forms of CAM used to treat a variety of conditions. 9,10 While recent studies report on its efficacy for dry eye, [11][12][13] there is lack of consensus on the most effective acupuncture method. This can be attributed to the study design, insufficient sample sizes, and few therapeutic sessions.…”

Section: Introductionmentioning

confidence: 99%

Laser Acupuncture Improves Tear Film Stability in Patients with Dry Eye Disease: A Two-Center Randomized-Controlled Trial

Pan

et al. 2021

The Journal of Alternative and Complementary Medicine

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Objectives: To investigate the efficacy of laser acupuncture (LA) therapy in patients with dry eye disease (DED). Design: A two-center randomized controlled trial. Settings/Location: The Department of Ophthalmology, Chinese Medicine at the Kaohsiung Chang Gung Memorial Hospital, and the Sunming Eye Clinic in South Taiwan. Subjects: Fifty-nine participants ages 20 to 65 years were enrolled and randomly assigned to the experimental group (LA plus conventional treatment) or the sham control group (LA without laser output plus conventional treatment). Interventions: Subjects underwent LA treatment three times a week for 12 weeks. The subjects in the experimental group sequentially received 0.375 J of energy at each of the following acupoints: BL2, TE23, ST2, LI4, ST36, and GB37. Subjects in the control group received a sham LA treatment, without any laser output. Outcome Measures: The primary outcome measure was ocular surface disease index (OSDI). The secondary outcome measures included tear film breakup time (TFBUT), Schirmer-I test finding, and visual analog scale (VAS) score. Results: At 4 and 12 weeks after the first visit, the experimental group showed significant improvement of dry eye symptoms as measured by OSDI, TFBUT, Shirmer-I test, and VAS. Compared with the control group, the OSDI (7.23, p = 0.001) and TFBUT (−1.78, p = 0.001) significantly improved in the experimental group at 12 weeks of treatment. Conclusions: LA improved the symptoms and tear stability related to DED in conjunction with conventional treatment. The authors suggest that LA be considered a complementary therapy for DED when conventional treatment does not provide satisfactory effects. Trial Registration: Identifier NCT03204903.

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“…Acupuncture is an ancient therapy with a history of thousands of years and is now widely used in the medical system. Some clinical studies and systematic reviews show that acupuncture is increasingly used in the clinical treatment of many eye diseases, including dry eye syndrome, [ 20 ] blepharoptosis, [ 21 ] oculomotor paralysis, [ 22 ] blepharospasm, [ 23 ] and other ophthalmic diseases, and has a good effect. [ 24 , 25 ] In addition, some randomized controlled trials (RCTs) have reported that acupuncture, as an adjuvant therapy, can effectively improve the diopter and vision in the sense of myopic children.…”

Section: Introductionmentioning

confidence: 99%

Clinical study on acupuncture acupoints around the eyes in treating myopia in children and adolescents

Huang¹,

Yang²,

Huang³

et al. 2020

Medicine

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Introduction: Myopia is the most common cause of avoidable visual impairment worldwide, which causes huge economic burden and social burden. There are several ways to treat and reduce myopia, but all have drawbacks; this reality drives us to search for additional effective and low-risk interventions of treatment for myopia. Acupuncture is an ancient therapy with a history of thousands of years and is now widely used in the medical system. Some randomized controlled trials have reported that acupuncture, as an adjuvant therapy, can effectively improve the diopter and vision in the sense of myopic children. Deqi is a long-standing belief to ensure the efficacy of acupuncture in the treatment of myopia, but this belief has not been confirmed by sufficient evidence of randomized controlled trials. Methods: This clinical study is a parallel-group, randomized controlled, and single blind study. Three hundred eligible adolescents will randomly be divided into acupuncture Deqi group, acupuncture without Deqi group, and waiting list group. All groups will be given frame glasses for corrective treatment; patients in the acupuncture Deqi group will be treated with acupuncture at acupoints around the eyes and flat puncture to Deqi, while acupuncture without Deqi group will not flat puncture to Deqi. The waiting list group will not receive acupuncture treatment. The primary outcome will be diopter measurement. Adverse events and safety indexes will be recorded throughout the study. Discussion: Our study will compare acupuncture Deqi with acupuncture without Deqi, and place it in a control group for the treatment of myopia. The results of this trial are expected to provide solid evidence for the effectiveness and safety of acupuncture combined with Deqi in the treatment of myopia, and hope to provide a reference for clinical practice. The primary outcome will be diopter measurement of the patients before treatment. Trial registration: ChiCTR2000037874, registered September 3, 2020.

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Optimizing acupuncture treatment for dry eye syndrome: a systematic review

Cited by 94 publications

References 26 publications

Acupoint selection for the treatment of dry eye: A systematic review and meta‑analysis of randomized controlled trials

Acupoint selection for the treatment of dry eye: A systematic review and meta‑analysis of randomized controlled trials

Laser Acupuncture Improves Tear Film Stability in Patients with Dry Eye Disease: A Two-Center Randomized-Controlled Trial

Clinical study on acupuncture acupoints around the eyes in treating myopia in children and adolescents

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