This chapter describes some recent research in the field of supramolecular polymeric hydrogels. Eight examples are discussed that represent a small view of the plethora of these advanced functional materials. The examples described herein exhibit tunable physicochemical properties that allow for adjustment towards targeted applications in the biomedical field, including protein immobilization, tissue engineering, drug delivery, and dermocosmetics. The highly adaptive supramolecular polymeric hydrogels are likely to have a bright future as materials for medicine.