Optimized synthesis and crystalline stability of γ-cyclodextrin metal-organic frameworks for drug adsorption

Liu, Botao; Li, Haiyan; Xu, Xiaonan; Li, Xue; Lv, Nana; Singh, Vikramjeet; Stoddart, J. Fraser; York, Peter; Xu, Xu; Gref, Ruxandra; Zhang, Jiwen

doi:10.1016/j.ijpharm.2016.09.029

Cited by 122 publications

(117 citation statements)

References 45 publications

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“…Cyclodextrin-based metal-organic frameworks (γ-CD-MOFs) were obtained by the modified vapour diffusion method, which has been previously reported [13,[17][18][19]. The crystals were prepared by reacting γ-CD (1 mmol) with a solution of metal (8 mmol), derived from metal salts such as potassium hydroxide, sodium hydroxide and iron chloride, in 20 mL of aqueous solution.…”

Section: Synthesis Of γ-Cd-mofsmentioning

confidence: 99%

“…The γ-CD-MOF became popular due to their biocompatibility and potential application for entrapment molecules and for biomedical purposes. Despite this growing interest in the development of "green" MOFs with cyclodextrin, there has not been much effort with regard to drug delivery systems [17,18]. We describe here a method for the encapsulation and controlled release of an anti-inflammatory drug model, sodium diclofenac (DFNa), by different MOFs with γ-cyclodextrin (γ-CD-MOF): γ-KCD, γ-NaCD and γ-FeCD.…”

Section: Introductionmentioning

confidence: 99%

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Supramolecular cyclodextrin-based metal-organic frameworks as efficient carrier for anti-inflammatory drugs

Abuçafy

Caetano

Chiari-Andréo

et al. 2018

European Journal of Pharmaceutics and Biopharmaceutics

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Drug delivery systems have been used to reduce adverse effects and improve the efficacy of therapies. Drug carriers have been developed over the years, but they have limitations. γ-cyclodextrin-based metal-organic frameworks (γ-CD-MOF) have significant advantages due to their biocompatibility and environmental safety, besides crystallinity and porosity. Herein, γ-CD-MOFs were synthesised with different metals as nodes and investigated. Uniform mesoporous γ-CD-MOFs were obtained and showed an absence of toxicity in HepG2 and Caco-2 cells. The longer controlled release was verified for γ-CD-MOFs, with a maximum of 62% released in 12 h. An inflammation experiment was performed in mice and activity equivalent to the positive control was verified. γ-KCD-MOFs and γ-NaCD-MOFs reached activity after 6 h of administration, however this happened after 24 h in γ-FeCD-MOFs, being more effective than the positive control. Considering the ability for drug entrapment, easy preparation and controlled release, this class of material allows potential applications in drug delivery systems.

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Section: Synthesis Of γ-Cd-mofsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Supramolecular cyclodextrin-based metal-organic frameworks as efficient carrier for anti-inflammatory drugs

Abuçafy

Caetano

Chiari-Andréo

et al. 2018

European Journal of Pharmaceutics and Biopharmaceutics

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“…37,38 The 'breath effects' may not only be due to the inherent flexibility and porosity of the -CD linker, but also due to its weak coordination bonds with K + cations. Pressure and temperature were observed to influence the adsorption performance of CD-MOF materials because of their sensitivity to external conditions.…”

Section: Synthesis and Characterizationmentioning

confidence: 99%

“…Pressure and temperature were observed to influence the adsorption performance of CD-MOF materials because of their sensitivity to external conditions. 37,38 The 'breath effects' may not only be due to the inherent flexibility and porosity of the -CD linker, but also due to its weak coordination bonds with K + cations. 38 At 298 K, the amount of mX and pX adsorbed reached their plateau at a pressure of 8 mbar.…”

Section: Synthesis and Characterizationmentioning

confidence: 99%

Efficient adsorption separation of xylene isomers using a facilely fabricated cyclodextrin‐based metal–organic framework

Chen

Zhu

et al. 2018

J of Chemical Tech & Biotech

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Background Metal−organic frameworks (MOFs) are energy‐efficient adsorbents for separating industrial chemical feedstocks. A type of MOF containing an extended porous network of γ‐cyclodextrin (γ‐CD) and alkali metal salts, CD‐MOF, has potential applications in adsorption separation processes in the petrochemical industry. This study aims to present the adsorption efficiency of CD‐MOF‐1 in separating xylene regioisomers. Results The adsorption separation of xylene regioisomers on layered CD‐MOF‐1 microcrystals was studied using batch vapor‐phase adsorption and liquid‐phase breakthrough adsorption. CD‐MOF‐1 showed preferable adsorption of o‐xylene over the other two isomers, with adsorption strength in the order o‐xylene (oX) > m‐xylene (mX) > p‐xylene (pX). With increased temperature, high adsorption capacities of oX and mX over pX were detected. However, this also resulted in a decrease of the separation factors of oX/pX and mX/pX. Conclusion The high resolution and large separation factors for oX/pX and mX/pX make CD‐MOF‐1 an efficient and reliable alternative adsorbent to the isolation protocols for xylene isomers currently used in the petrochemical industry. © 2018 Society of Chemical Industry

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“…Among three common cyclodextrins (α, β, and γ), the γ-CD has the largest cavity dimension (up to about 427 Å 3 , compared with 174 Å 3 of α-CD and 262 Å 3 of β-CD), thus it is regarded as the greater and wider inclusion capabilities to various organic molecules, and is supposed to be a more effective adsorbing material in dyestuff wastewater treatment. While the water solubility and shaping difficulty of γ-CD have restricted its application in wastewater treatment [16,17].…”

Section: Introductionmentioning

confidence: 99%

Preparing γ-Cyclodextrin-Immobilized Starch and the Study of its Removal Properties to Dyestuff from Wastewater

Zhang¹,

Zhang²,

Cheng³

et al. 2019

Pol. J. Environ. Stud.

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A novel natural polymeric adsorbing material γ-cyclodextrin immobilized starch (CS-γCD) was prepared by introducing host functional molecule γ-cyclodextrin (γ-CD) into starch, using epichlorohydrin (ECH) as a cross-linking agent and sodium hydroxide as a catalyst, via the aqueous-phase synthesis method. The γ-cyclodextrin content in CS-γCD was up to 8.15% determined by the bromocresol green (BCG) hyperchromic spectrophotometric method. The structures of CS-γCD were characterized by infrared spectrum (FT-IR), 13 C-nuclear magnetic resonance spectrum ( 13 C-NMR), scanning electron microscope (SEM), x-ray diffraction (XRD), and gel permeation chromatography (GPC). We investigated the adsorption performances and kinetics of CS-γCD to three different kinds of dyestuff including methylene blue (MB), methyl purple (MP), and congo red (CR). The results showed the adsorbing capacities of CS-γCD to three kinds of dyes had obviously increased compared with native starch and diatomite, and the CS-γCD was also found to have a significant advantage in adsorption of macro-molecule dye such as CR over other adsorbing materials. The adsorption behaviors of CS-γCD on the three dyestuffs could be better described by a Langmuir model (R 2 >0.99), but also had relatively high correlation to Freundlich model. The pseudo second-order model could better describe the adsorption behaviors. The CS-γCD could be enzymolysised, while its degradation rate was much lower than native starch, which indicated that CS-γCD had a relatively higher structural stability and longer service life, these characters could be beneficial for the popularization and application of CS-γCD in fields of wastewater treatment and environment remediation.

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Optimized synthesis and crystalline stability of γ-cyclodextrin metal-organic frameworks for drug adsorption

Cited by 122 publications

References 45 publications

Supramolecular cyclodextrin-based metal-organic frameworks as efficient carrier for anti-inflammatory drugs

Supramolecular cyclodextrin-based metal-organic frameworks as efficient carrier for anti-inflammatory drugs

Efficient adsorption separation of xylene isomers using a facilely fabricated cyclodextrin‐based metal–organic framework

Preparing γ-Cyclodextrin-Immobilized Starch and the Study of its Removal Properties to Dyestuff from Wastewater

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