Optimized project of traditional Chinese medicine in treating chronic kidney disease stage 3: A multicenter double-blinded randomized controlled trial

Wang, Yongjun; He, Liqun; Sun, Weijian; Lü, Ying; Wang, Xiaoqin; Zhang, Pei-qing; Wei, Lianbo; Shi-li, Cao; Yang, Ning; Ma, Hui; Gao, Jing; Li, Ping; Tao, Xiaojuan; Yuan, Fang; Li, Jing; Yao, Chen; Liu, Xusheng

doi:10.1016/j.jep.2011.12.009

Cited by 62 publications

(52 citation statements)

References 46 publications

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“…Through the synergistic effect of multi-components, multi-channels and multi-targets, it showed significant advantages over a single drug treatments, especially for the treatment of chronic complex, multi-factorial diseases [1], [2]. Compared to western medicine, it has been observed to have lower side effects [3]–[6]. However, for a long time, due to complex chemical composition, prescription diversity and the lack of an effective research approach, the investigation of active compounds and pharmacological mechanisms of action has encountered great challenges, thus becoming one of the main bottlenecks of modernization and internationalization of TCM.…”

Section: Introductionmentioning

confidence: 99%

A Network Pharmacology Approach to Understanding the Mechanisms of Action of Traditional Medicine: Bushenhuoxue Formula for Treatment of Chronic Kidney Disease

Shi

Cai

et al. 2014

PLoS ONE

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Traditional Chinese medicine (TCM) has unique therapeutic effects for complex chronic diseases. However, for the lack of an effective systematic approach, the research progress on the effective substances and pharmacological mechanism of action has been very slow. In this paper, by incorporating network biology, bioinformatics and chemoinformatics methods, an integrated approach was proposed to systematically investigate and explain the pharmacological mechanism of action and effective substances of TCM. This approach includes the following main steps: First, based on the known drug targets, network biology was used to screen out putative drug targets; Second, the molecular docking method was used to calculate whether the molecules from TCM and drug targets related to chronic kidney diseases (CKD) interact or not; Third, according to the result of molecular docking, natural product-target network, main component-target network and compound-target network were constructed; Finally, through analysis of network characteristics and literature mining, potential effective multi-components and their synergistic mechanism were putatively identified and uncovered. Bu-shen-Huo-xue formula (BSHX) which was frequently used for treating CKD, was used as the case to demonstrate reliability of our proposed approach. The results show that BSHX has the therapeutic effect by using multi-channel network regulation, such as regulating the coagulation and fibrinolytic balance, and the expression of inflammatory factors, inhibiting abnormal ECM accumulation. Tanshinone IIA, rhein, curcumin, calycosin and quercetin may be potential effective ingredients of BSHX. This research shows that the integration approach can be an effective means for discovering active substances and revealing their pharmacological mechanisms of TCM.

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Section: Introductionmentioning

confidence: 99%

A Network Pharmacology Approach to Understanding the Mechanisms of Action of Traditional Medicine: Bushenhuoxue Formula for Treatment of Chronic Kidney Disease

Shi

Cai

et al. 2014

PLoS ONE

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“…60 These patients received either traditional medicines, benazepril, or a combination of the 2. A composite primary end point of 50% increase in serum creatinine level, ESRD, or death was used.…”

Section: Large Randomized Clinical Trials Of Traditional Medicines Inmentioning

confidence: 99%

Recent Advances in Traditional Chinese Medicine for Kidney Disease

Zhong

Menon

Deng

et al. 2015

American Journal of Kidney Diseases

113

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“…32 For the patients with CKD stage 3, TCMs can improve estimated glomerular filtration rate (eGFR) and hemoglobin with lower side effects. 33 TCM Hachimi-jio-gan played a protective role in the progression of CRF through the decline in uremic toxins, elevation of antioxidative enzyme activity such as superoxide dismutase and catalase, and amelioration of histopathological lesions in the kidney. 34 Cumulative evidence suggests that some TCMs, including Astragalus and a mixture of Astragalus plus Angelica, Ligusticum, Triptolide, and Rhubarb, show benefits in slowing the progression of CKD.…”

Section: The Role Of Tcms In the Treatment Of Crfmentioning

confidence: 99%

Hot bath for the treatment of chronic renal failure

2013

Renal Failure

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Background: Dialysis and its complications were debated recently. There was lack of an adjuvant renal replacement method to reduce the complications of patients with chronic renal failure and dialysis itself. Materials and methods: In this article, we reviewed the role of thermal sweating in treating of the patients with chronic renal failure, and the role of traditional Chinese medicine in the therapy of chronic kidney diseases. Results: Thermal sweating can reduce interdialytic weight gain and improve the patients' blood pressure; Chinese herbal medicine can promote the excretion of uremic toxicities and relieve the skin disorders of these patients. Conclusions: Traditional Chinese medicine-mediated hot bath could be one of the adjuvant renal replacement methods.

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Optimized project of traditional Chinese medicine in treating chronic kidney disease stage 3: A multicenter double-blinded randomized controlled trial

Cited by 62 publications

References 46 publications

A Network Pharmacology Approach to Understanding the Mechanisms of Action of Traditional Medicine: Bushenhuoxue Formula for Treatment of Chronic Kidney Disease

A Network Pharmacology Approach to Understanding the Mechanisms of Action of Traditional Medicine: Bushenhuoxue Formula for Treatment of Chronic Kidney Disease

Recent Advances in Traditional Chinese Medicine for Kidney Disease

Hot bath for the treatment of chronic renal failure

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