Optimized microburst VNS elicits fMRI responses beyond thalamic‐specific response from standard VNS
Jerzy P. Szaflarski,
Jane B. Allendorfer,
Jason Begnaud
et al.
Abstract:ObjectiveIn parallel to standard vagus nerve stimulation (VNS), microburst stimulation delivery has been developed. We evaluated the fMRI‐related signal changes associated with standard and optimized microburst stimulation in a proof‐of‐concept study (NCT03446664).MethodsTwenty‐nine drug‐resistant epilepsy patients were prospectively implanted with VNS. Three 3T fMRI scans were collected 2 weeks postimplantation. The maximum tolerated VNS intensity was determined prior to each scan starting at 0.125 mA with 0.… Show more
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