Abstract:Inflammasomes are innate immune signaling platforms that
trigger
pyroptotic cell death. NLRP1 and CARD8 are related human inflammasomes
that detect similar danger signals, but NLRP1 has a higher activation
threshold and triggers a more inflammatory form of pyroptosis. Both
sense the accumulation of intracellular peptides with Xaa-Pro N-termini,
but Xaa-Pro peptides on their own without a second danger signal only
activate the CARD8 inflammasome. We recently reported that a dual
inhibitor of the Xaa-Pro-cleavin… Show more
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