Optimized Chromatographic Separation and Bioevalution of Radioiodinated Ilaprazole as a New Labeled Compound for Peptic Ulcer Localization in Mice

Sanad, M. H.; Eyssa, H. M.; Marzook, F. A.; Farag, Ayman; Rizvi, Syed Faheem Askari; Mandal, Sudip Kumar; Patnaik, Soumya Stuti; Fouzy, A. S. M.

doi:10.1134/s1066362221060138

Cited by 9 publications

(2 citation statements)

References 103 publications

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“…The total yield of the radiotracer consists of free [ 125 I] -iodide and [ 125 I] -ZEN it is calculated from the percentage (%), on TLC at RTs (retention times) 0.0 and 0.9–1.0 respectively. HPLC analysis revealed the following, the purity for [ 125 I]-ZEN reached 99 % [ [101] , [102] , [103] , [104] , [105] , [106] , [107] , [108] , [109] , [110] , [111] , [112] , [113] , [114] , [115] , [116] , [117] , [118] , [119] , [120] ]. The Retention times values for both the free iodide and the labeled molecule [ 125 I]-ZEN existed at 4.5 and 15.8 min, respectively, with regard to the retention time for ZEN that was 14.7 min ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Radioiodination of zearalenone and determination of Lactobacillus plantarum effect of on zearalenone organ distribution: In silico study and preclinical evaluation

et al. 2022

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Section: Resultsmentioning

confidence: 99%

Radioiodination of zearalenone and determination of Lactobacillus plantarum effect of on zearalenone organ distribution: In silico study and preclinical evaluation

et al. 2022

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“…which is higher than the two radiotracers [ 131 I] iodosulfasalazine and [ 131 I] iodobalsalazide gave 75.5 and 73 % at 24 hours postinjection. according to [111][112][113][114][115][116][117][118][119][120][121][122][123][124][125][126]. Therefore, it is clear that (PPAR) antagonist expression levels rise at the onset of the disease, and the radiotracer is anticipated to interact with that receptor, which is strongly expressed in the target organ, ulcerative colitis.…”

Section: -Investigations Using Molecular Modellingmentioning

confidence: 99%

Radioiodination, and Biological Assessment of Olsalazine, as a Highly Selective Radiotracer for Ulcerative Colitis Imaging in Mice

Sanad

Marzook

Challan

et al. 2023

Arab Journal of Nuclear Sciences and Applications

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Ulcerative colitis (UC) is a chronic, regressive natural disease. The use of conventional diagnostic procedures such as magnetic resonance imaging, ultrasonography, and X-rays during the dormant and early stages of the disease does not aid in diagnosing the disease. As a result, a novel design, such as labelled compounds, were used to image ulcerative colitis disease. In this study, olsalazine was labeled with [ 125/131 I] and the labelling parameters were adjusted to obtain a high radiochemical yield (98.5%). In addition, the olsalazine radiotracer gave 96.0% purity in rate serum for up to twelve hours before it started to degrade at twenty-four hours, and it was stable also, in saline for up to twentyfour hours. Molecular docking was used to assess a complex's affinity for its biological target, and the PPAR receptor. The biological assessment was also performed in mice models of both standard and ulcerative colitis. The results demonstrated that [ 125/131 I] iodoolsalazine had a high uptake of 79.5% (ID/g) at 120 minutes post-injection and is still high to 77% at 24 hours. So, the labelled compound, [ 125/131 I] iodoolsalazine, could be considered a new potential selective radiotracer for preclinical diagnostic research of ulcerative colitis.

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Radioiodination and Biological Evaluation of Novel Quinoline Derivative for Infective Inflammation Diagnosis

Sanad,

Gomaa,

El Bakary

et al. 2023

Pharm Chem J

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Optimized Chromatographic Separation and Bioevalution of Radioiodinated Ilaprazole as a New Labeled Compound for Peptic Ulcer Localization in Mice

Cited by 9 publications

References 103 publications

Radioiodination of zearalenone and determination of Lactobacillus plantarum effect of on zearalenone organ distribution: In silico study and preclinical evaluation

Radioiodination of zearalenone and determination of Lactobacillus plantarum effect of on zearalenone organ distribution: In silico study and preclinical evaluation

Radioiodination, and Biological Assessment of Olsalazine, as a Highly Selective Radiotracer for Ulcerative Colitis Imaging in Mice

Radioiodination and Biological Evaluation of Novel Quinoline Derivative for Infective Inflammation Diagnosis

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