Optimization, synthesis, and characterization of coaxial electrospun sodium carboxymethyl cellulose-graft-methyl acrylate/poly(ethylene oxide) nanofibers for potential drug-delivery applications

Esmaeili, Akbar; Haseli, Mahsa

doi:10.1016/j.carbpol.2017.06.037

Cited by 56 publications

(9 citation statements)

References 29 publications

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“…32 nm and a finer particle of 80 nm. Other studies examining drug delivery show a similar morphology for nanoparticles (Esmaeili and Haseli 2017).…”

Section: Scanning Electron Microscopy (Sem)mentioning

confidence: 65%

In vivo, in vitro, and antibacterial activity of Fe3O4@RIF-BUP-CMCs-modified by fatty acids nanoparticles to remove drug liver toxins

Masoumi

Esmaeili

2020

Appl Nanosci

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In this study, the encapsulated Fe 3 O 4 @rifampin (RIF)/buprenorphine (BUP)/carboxy methyl modified with modified fatty acids (CMCs-MFAs) nanoparticles were hybridized to form Fe 3 O 4 @RIF-BUP-CMCs-MNFAs NPs. The best fatty acid that could be modified in this process was oleic acid. This paper examines the changes (pH, absorption rate, drug release, in vivo test (30 male) in selected Wistar rats. All males were orally addicted to morphine after 21 days. After establishing dependence based on an observation of behavioral parameters the ability to quit the new drug was evaluated. In vitro and in vitro tests on antibacterial activity and multiple intestinal inflammation in addicts were conducted. The slow release study revealed that CMCs-MFAs NPs increase the release and longer release of RIF in the body. It did not increase significantly the measurement of enzymes (ALT and AST). The production of NPs caused less damage to liver tissue than BUP while trying to quit addiction. Images of the liver revealed that the designed NPs did less damage to liver tissue than the main drug BUP. Antibacterial activity showed more inflammation for BUP without NPs and less inflammation with the Fe 3 O 4 @RIF-BUP-CMCs-MFAs NPs. In this project the modified dose was reduced from 0.004 to 0.0005 µg. The next goal is to extend the release of BUP in the body using CMCs-MFAs (72-96 h).

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“…32 nm and a finer particle of 80 nm. Other studies examining drug delivery show a similar morphology for nanoparticles (Esmaeili and Haseli 2017).…”

Section: Scanning Electron Microscopy (Sem)mentioning

confidence: 65%

In vivo, in vitro, and antibacterial activity of Fe3O4@RIF-BUP-CMCs-modified by fatty acids nanoparticles to remove drug liver toxins

Masoumi

Esmaeili

2020

Appl Nanosci

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“…However, Figure 8 indicates that sample I was more hydrophobic (a larger contact angle than other composite nanofiber mats). This might be because the core-shell structured nanofiber is more hydrophobic than the monoaxial structured nanofiber [69].…”

Section: Contact Angle Studiesmentioning

confidence: 99%

Multi-Functional Core-Shell Nanofibers for Wound Healing

Shunqi

Dong

et al. 2021

Nanomaterials

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Core-shell nanofibers have great potential for bio-medical applications such as wound healing dressings where multiple drugs and growth factors are expected to be delivered at different healing phases. Compared to monoaxial nanofibers, core-shell nanofibers can control the drug release profile easier, providing sustainable and effective drugs and growth factors for wound healing. However, it is challenging to produce core-shell structured nanofibers with a high production rate at low energy consumption. Co-axial centrifugal spinning is an alternative method to address the above limitations to produce core-shell nanofibers effectively. In this study, a co-axial centrifugal spinning device was designed and assembled to produce core-shell nanofibers for controlling the release rate of ibuprofen and hEGF in inflammation and proliferation phases during the wound healing process. Core-shell structured nanofibers were confirmed by TEM. This work demonstrated that the co-axial centrifugal spinning is a high productivity process that can produce materials with a 3D environment mimicking natural tissue scaffold, and the specific drug can be loaded into different layers to control the drug release rate to improve the drug efficiency and promote wound healing.

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“…While after two days, the TCMC4/PEO(CS) revealed no cytotoxicity and the TCMC4/PEO/TCH(CS) nanofibers demonstrated a decrease in the viability of human fibroblasts (HDF) reporting that the released TCH at 24 h and 48 h affected cell viability. 106 Further, different quantities of cellulose nanocrystals (CNCs) were blended with gelatin hydrogels with glutaraldehyde used as a crosslinker, due to its high reactivity toward the -NH 2 group of gelatin, and on account of the weak mechanical properties of gelatin. Figure 6 shows a schematic of a typical preparation process of a nanocarrier based on carboxymethyl cellulose (CMC) based on the reaction between different functional groups as well as loading of the drug into the main core of the nanocarrier along with conjugation to the surface.…”

Section: Applications Of Cellulose and Its Blend Derivative In Cddssmentioning

confidence: 99%

<p>Burgeoning Polymer Nano Blends for Improved Controlled Drug Release: A Review</p>

Maghsoudi¹,

Shahraki²,

Rabiee³

et al. 2020

IJN

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With continual rapid developments in the biomedical field and understanding of the important mechanisms and pharmacokinetics of biological molecules, controlled drug delivery systems (CDDSs) have been at the forefront over conventional drug delivery systems. Over the past several years, scientists have placed boundless energy and time into exploiting a wide variety of excipients, particularly diverse polymers, both natural and synthetic. More recently, the development of nano polymer blends has achieved noteworthy attention due to their amazing properties, such as biocompatibility, biodegradability and more importantly, their pivotal role in controlled and sustained drug release in vitro and in vivo. These compounds come with a number of effective benefits for improving problems of targeted or controlled drug and gene delivery systems; thus, they have been extensively used in medical and pharmaceutical applications. Additionally, they are quite attractive for wound dressings, textiles, tissue engineering, and biomedical prostheses. In this sense, some important and workable natural polymers (namely, chitosan (CS), starch and cellulose) and some applicable synthetic ones (such as poly-lactic-co-glycolic acid (PLGA), poly(lactic acid) (PLA) and poly-glycolic acid (PGA)) have played an indispensable role over the last two decades for their therapeutic effects owing to their appealing and renewable biological properties. According to our data, this is the first review article highlighting CDDSs composed of diverse natural and synthetic nano biopolymers, blended for biological purposes, mostly over the past five years; other reviews have just briefly mentioned the use of such blended polymers. We, additionally, try to make comparisons between various nano blending systems in terms of improved sustained and controlled drug release behavior.

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Optimization, synthesis, and characterization of coaxial electrospun sodium carboxymethyl cellulose-graft-methyl acrylate/poly(ethylene oxide) nanofibers for potential drug-delivery applications

Cited by 56 publications

References 29 publications

In vivo, in vitro, and antibacterial activity of Fe3O4@RIF-BUP-CMCs-modified by fatty acids nanoparticles to remove drug liver toxins

In vivo, in vitro, and antibacterial activity of Fe3O4@RIF-BUP-CMCs-modified by fatty acids nanoparticles to remove drug liver toxins

Multi-Functional Core-Shell Nanofibers for Wound Healing

<p>Burgeoning Polymer Nano Blends for Improved Controlled Drug Release: A Review</p>

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