Optimization Study of the Hemodynamics of Saline Flushing in Endoscopic Imaging of Chronic Total Occlusions (CTOs)

Faisal, Syed; Seibel, Eric J.; Aliseda, Alberto

doi:10.1007/s13239-021-00550-x

Cited by 3 publications

(3 citation statements)

References 31 publications

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“…Additionally, the previous paper states that inducing too much pressure inside the coronary artery by flushing is unsafe for a patient [ 22 ]. The increase in pressure inside the coronary artery induced by dextran injection needs to be considered in the future.…”

Section: Discussionmentioning

confidence: 99%

“…Okayama et al developed a catheter with holes on its side surface to spray the dextran to the wall, to make the flush flow reach the vessel wall [ 21 ]. Additionally, Faisal et al investigated the flushing flow conditions and pressure inside the artery during angioscopy using a simplified model to optimize the hole shape on the catheter [ 22 ]. These studies and developments appear promising but realizing the use of these new devices in treatment may take time, as their effectivity is verified.…”

Section: Introductionmentioning

confidence: 99%

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A Parametric Study of Flushing Conditions for Improvement of Angioscopy Visibility

Mitsuzuka

Nakayama

et al. 2022

JFB

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During an angioscopy operation, a transparent liquid called dextran is sprayed out from a catheter to flush the blood away from the space between the camera and target. Medical doctors usually inject dextran at a constant flow rate. However, they often cannot obtain clear angioscopy visibility because the flushing out of the blood is insufficient. Good flushing conditions producing clear angioscopy visibility will increase the rate of success of angioscopy operations. This study aimed to determine a way to improve the clarity for angioscopy under different values for the parameters of the injection waveform, endoscope position, and catheter angle. We also determined the effect of a stepwise waveform for injecting the dextran only during systole while synchronizing the waveform to the cardiac cycle. To evaluate the visibility of the blood-vessel walls, we performed a computational fluid dynamics (CFD) simulation and calculated the visible area ratio (VAR), representing the ratio of the visible wall area to the total area of the wall at each point in time. Additionally, the normalized integration of the VAR called the area ratio (ARVAR) represents the ratio of the visible wall area as a function of the dextran injection period. The results demonstrate that the ARVAR with a stepped waveform, bottom endoscope, and three-degree-angle catheter results in the highest visibility, around 25 times larger than that under the control conditions: a constant waveform, a center endoscope, and 0 degrees. This set of conditions can improve angioscopy visibility.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Parametric Study of Flushing Conditions for Improvement of Angioscopy Visibility

Mitsuzuka

Nakayama

et al. 2022

JFB

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“…In silico experiments can offer doctors invaluable data that can hardly be obtained through in vivo operations. Researchers have carried out relevant investigations on intravascular injection relying on numerical simulation, such as contrast agent injection 9 , 22 , normal saline injection 23 – 25 and intravascular administration 26 . However, the existing numerical efforts focus only on modelling fluid flow and mixing, which is just one part of the OCT operation.…”

Section: Introductionmentioning

confidence: 99%

In silico intravascular optical coherence tomography (IVOCT) for quality assured imaging with reduced intervention

Zhuo,

Huang,

Xiao

2024

Sci Rep

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In the clinical application of intravascular optical coherence tomography (IVOCT), it is necessary to flush opaque blood during image acquisition. However, there are no specific standards for how to perform low-dose but effective flushing. In this study, computational fluid dynamics (CFD) and optical models were integrated to numerically simulate the complete process of IVOCT, which includes blood flushing with normal saline followed by image acquisition. Moreover, an intermittent injection scheme was proposed, and its advantages over the conventionally adopted scheme of continuous injection were verified. The results show that intermittent injection can significantly reduce the dosage of normal saline (reduced by 44.4%) with only a slight sacrifice of image quality (reduced by 8.7%, but still acceptable). The developed model and key findings in this work can help surgeons practice optimized IVOCT operations and potentially lead to improved designs of the IVOCT equipment.

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Hemodynamics of Saline Flushing in Endoscopic Imaging of Partially Occluded Coronary Arteries

Faisal,

Barbour,

Seibel

et al. 2024

Cardiovasc Eng Tech

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Optimization Study of the Hemodynamics of Saline Flushing in Endoscopic Imaging of Chronic Total Occlusions (CTOs)

Cited by 3 publications

References 31 publications

A Parametric Study of Flushing Conditions for Improvement of Angioscopy Visibility

A Parametric Study of Flushing Conditions for Improvement of Angioscopy Visibility

In silico intravascular optical coherence tomography (IVOCT) for quality assured imaging with reduced intervention

Hemodynamics of Saline Flushing in Endoscopic Imaging of Partially Occluded Coronary Arteries

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