Abstract:Experimental design approach has been used for optimization of film-coating phase of the immediate release tablets manufacturing process in order to evaluate the effects of the potential critical process parameters (CPPs) and define the optimal operating conditions. Optimization was performed during the transfer of the process on a film-coating machine for pilot and industrial scale production. Immediate release ready-to-use coating system Opadry ® White was used as the coating. Central Composite Orthogonal de… Show more
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