Optimization of Urea-Glycerin Based NADES-UAE for Oxyresveratrol Extraction from Morus alba Roots for Preparation of Skin Whitening Lotion

Alishlah, Tanfidz; Mun’im, Abdul; Jufri, Mahdi

doi:10.5530/jyp.2019.11.33

Cited by 10 publications

(5 citation statements)

References 20 publications

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“…Therefore, the moisturizing ability of hydrogel should also be systematically studied. It is worth noting that glycerin has a strong moisturizing ability, which is widely used in the field of skincare products [38][39][40]. Hence, in our experiment, a certain amount of glycerin was added to the prepolymer solution of the hydrogel to enhance moisture retention.…”

Section: Hydrogel Moisturizing Ability Measurementsmentioning

confidence: 99%

A novel flexible hydrogel electrode with a strong moisturizing ability for long-term EEG recording

et al. 2021

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Objective: A novel flexible hydrogel electrode with a strong moisturizing ability was prepared for long-term electroencephalography (EEG) monitoring. Approach: The hydrogel was synthesized by polymerizing the N-acryloyl glycinamide (NAGA) monomer. And a proper amount of glycerin was added to the hydrogel to increase the moisture retention ability of the electrodes. The hydrogel shows high mechanical properties, and the liquid in the hydrogel produces a hydrating effect on the skin stratum corneum, which could decrease the contact impedance between skin and electrode. In addition, the installation of hydrogel electrode is very convenient, and the skin of the subject does not need to be abraded. Main results: SEM images show that there are a large number of micropores in the hydrogel, which provide storage space for water molecules. The average potential drift of the hydrogel electrode is relatively low (1.974 ± 0.560 µV min-1). The average contact impedance of hydrogel electrode in forehead region and hair region are 6.43 ± 0.84 kΩ·cm2 and 13.15 ± 3.72 kΩ·cm2, respectively. The result of open/closed paradigm, steady-state visual evoked potentials (SSVEP), and P300 visual evoked potential show that hydrogel electrode has excellent performance. Compared with the hydrogel without glycerol, the moisture retention ability of hydrogel with glycerol was greatly improved. Significance. Compared with standard Ag/AgCl wet electrode, hydrogel electrode is more convenient to install and has strong moisture retention ability, which makes it have great potential in daily life for long-term EEG recording.

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Section: Hydrogel Moisturizing Ability Measurementsmentioning

confidence: 99%

A novel flexible hydrogel electrode with a strong moisturizing ability for long-term EEG recording

et al. 2021

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“…Previously, it was suggested that urea-glycerol-based NADES was a viable option for extracting oxyresveratrol from M. alba roots [20]. However, to obtain a variety of active compounds with anti-melanogenesis activity from M. alba callus, this study used a choline chloride-glycerol-based NADES.…”

Section: Stilbenoids Content and Anti-melanogenesis Activitymentioning

confidence: 99%

Preparation of Readily-to-Use Stilbenoids Extract from Morus alba Callus Using a Natural Deep Eutectic Solvent

et al. 2021

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The consumer and cosmetic industries have recently placed a greater emphasis on ecofriendly solvents for botanical extraction, including natural deep eutectic solvents (NADES). In this study, NADES were prepared for Morus alba callus extraction. The efficiency of extraction from the NADES and methanol was investigated by comparison of the stilbenoids yield and anti-melanogenesis activity. Prior to testing the irritability of a suitable NADES on the reconstructed human epidermis (RhE), the effect of the selected NADES on stilbenoids stability was determined. The results showed that the highest yields of stilbenoids were obtained from choline chloride-glycerol mixtures (Ch1G2) and methanol extracts, with no significant difference in yields (5.06 ± 0.05 and 6.32 ± 0.40 mg/g callus dry weight, respectively). The NADES extracts of M. alba callus showed comparable anti-melanogenesis activity compared to methanol. In term of stability, stilbenoids in Ch1G2 remained stable after six months of storage at 4 °C except resveratrol. Furthermore, Ch1G2 had no irritation effect on RhE. Thus, based on the findings of this study, Ch1G2 is an intriguing green solvent alternative for the extraction of M. alba callus and may be advantageous for the preparation of skin-lightening cosmetics.

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“…A number of studies illustrated that NADES can extract active constituents from Morus alba (Alishlah et al., 2019), Coffea canephora (Yuniarti et al., 2019), and Catharanthus roseus (Dai et al., 2016). The advantages of NADES include its easy application, relatively inexpensive costs, ready-to-use formulation, and biodegradable nature.…”

Section: Introductionmentioning

confidence: 99%

Optimization of choline chloride-glycerol based natural deep eutectic solvent for extraction bioactive substances from Cinnamomum burmannii barks and Caesalpinia sappan heartwoods

Sakti

Saputri

Mun’im

2019

Heliyon

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Indonesian cassia (Cinnamomum burmannii Blume) is commonly used as a condiment. It reportedly contains a number of major phytochemical constituents such as trans-cinnamaldehyde and coumarin. Sappan wood (Caesalpinia sappan) is a native plant of Southeast Asia that contains brazilin, a widely known red pigment. This study aimed to determine the optimal extraction conditions using a choline chloride-glycerol (ChCl-glycerol)-based natural deep eutectic solvent (NADES) to obtain greater trans-cinnamaldehyde and brazilin levels from Indonesian cassia and sappan wood. The powders of Indonesian cassia and sappan wood were extracted using ChClglycerol-based NADES varied at three different levels: ratio of ChCl to glycerol, ratio of powder to NADES, and the amount of water in NADES. All variables were designed using the Box-Behnken design of response surface methodology to provide 15 extraction conditions. The extraction was performed using ultrasonication-assisted extraction for 30 and 50 min for Indonesian cassia and sappan wood, respectively. Determination of the active compound contents was performed using a high-performance liquid chromatography system equipped with a UV-VIS detector at λmax ¼ 280 nm. The optimization results revealed that the highest levels of transcinnamaldehyde, coumarin, and brazilin in NADES extracts were 1907.32, 1735.68, and 368.67 μg/ml, respectively, whereas the lowest levels of these compounds were 453.59, 616.76, and 74.21 μg/ml, respectively. The maximal levels exceeded those obtained using a conventional extraction method, in which 5000 μg/ml Indonesian cassia reflux extract contained only 108.45 μg/ml trans-cinnamaldehyde. Similarly, 1000 μg/ml sappan wood contained only 124.64 μg/ml brazilin. ChCl-glycerol-based NADES was suitable for extracting active compounds from Indonesian cassia and sappan wood; moreover, this solvent is more effective than organic ethanolic coventional solvent.

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Optimization of Urea-Glycerin Based NADES-UAE for Oxyresveratrol Extraction from Morus alba Roots for Preparation of Skin Whitening Lotion

Cited by 10 publications

References 20 publications

A novel flexible hydrogel electrode with a strong moisturizing ability for long-term EEG recording

A novel flexible hydrogel electrode with a strong moisturizing ability for long-term EEG recording

Preparation of Readily-to-Use Stilbenoids Extract from Morus alba Callus Using a Natural Deep Eutectic Solvent

Optimization of choline chloride-glycerol based natural deep eutectic solvent for extraction bioactive substances from Cinnamomum burmannii barks and Caesalpinia sappan heartwoods

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