Optimization of ultrasound array designs for high intensity focused treatment of prostate cancer and benign prostatic hyperplasia

Lweesy, Khaldon; Fraiwan, Luay; Al-Bataineh, Osama M.; Hamdi, Naser; Dickhaus, Hartmut

doi:10.1007/s11517-009-0478-4

Cited by 8 publications

(5 citation statements)

References 15 publications

(18 reference statements)

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“…In the literature, acceptable side lobe levels have been variously given as 10% intensity (−10 dB) [21], 20% intensity (−7 dB) [42], or 10 to 16% intensity (−10 to −8 dB) [25] in homogeneous media. The temperature ratio in this work was shown to be 0.12 at the distal half-intensity axial depth for the 256-randomized-element case (Fig.…”

Section: Discussionmentioning

confidence: 99%

Design aspects of focal beams from high-intensity arrays

Stephens¹,

Kruse

Qin

et al. 2011

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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As the applications of ultrasonic thermal therapies expand, the design of the high-intensity array must address both the energy delivery of the main beam and the character and relevance of off-target beam energy. We simulate the acoustic field performance of a selected set of circular arrays organized by array format, including flat versus curved arrays, periodic versus random arrays, and center void diameter variations. Performance metrics are based on the −3-dB focal main lobe (FML) positioning range, axial grating lobe (AGL) temperatures, and side lobe levels. Using finite-element analysis, we evaluate the relative heating of the FML and the AGLs. All arrays have a maximum diameter of 100λ, with element count ranging from 64 to 1024 and continuous wave frequency of 1.5 MHz. First, we show that a 50% spherical annulus produces focus beam side lobes which decay as a function of lateral distance at nearly 87% of the exponential rate of a full aperture. Second, for the arrays studied, the efficiency of power delivery over the −3-dB focus positioning range for spherical arrays is at least 2-fold greater than for flat arrays; the 256-element case shows a 5-fold advantage for the spherical array. Third, AGL heating can be significant as the focal target is moved to its distal half-intensity depth from the natural focus. Increasing the element count of a randomized array to 256 elements decreases the AGL-to-FML heating ratio to 0.12 at the distal half-intensity depth. Further increases in element count yield modest improvements. A 49% improvement in the AGL-to-peak heating ratio is predicted by using the Sumanaweera spiral element pattern with randomization.

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Section: Discussionmentioning

confidence: 99%

Design aspects of focal beams from high-intensity arrays

Stephens¹,

Kruse

Qin

et al. 2011

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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“…The biological influence of LFU and microbubbles on cancer cells is dependent on the microbubble density, ultrasound intensity and irradiation time ( 34 , 35 ). Generally, a pilot experiment should be prepared to debug the optimized ultrasound parameters, so as to induce cell apoptosis to the maximum extent ( 36 , 37 ). Studies have identified that microbubbles enhance ultrasound exposure by decreasing the cavitation threshold ( 27 ), which induces cancer cell apoptosis ( 38 , 39 ).…”

Section: Discussionmentioning

confidence: 99%

Low‑frequency ultrasound and microbubbles combined with simvastatin promote the apoptosis of MCF‑7 cells by affecting the LATS1/YAP/RHAMM pathway

Chen

De-hang

2018

Mol Med Report

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Ultrasound scanning has widespread used in clinical practice and also has therapeutic applications. Simvastatin is a statins that is able to competitively inhibit the activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. The aim of the present study was to investigate the roles and mechanisms of low-frequency ultrasound (LFU) and microbubbles combined with simvastatin on MCF-7 cell growth and apoptosis. Cell viability, apoptosis and cell cycle were evaluated using an MTT assay and flow cytometry, respectively. The expression of related proteins was measured by western blot assay. The results revealed that simvastatin and LFU with microbubbles reduces the viability of MCF-7 cells. The combination of LFU and microbubbles with simvastatin promoted the apoptosis of MCF-7 cells. Furthermore, it was confirmed that LFU and microbubbles combined with simvastatin affected the large tumor suppressor 1 (LATS1)/yes-associated protein (YAP)/receptor of the hyaluronan-mediated motility (RHAMM) pathway in MCF-7 cells. It was determined that LATS1 acts as a negative regulator in the LATS1/YAP/RHAMM pathway in MCF-7 cells. In conclusion, the results of the present study indicate that LFU and microbubbles combined with simvastatin promotes the apoptosis of MCF-7 cells via the LATS1/YAP/RHAMM pathway. The present study suggested a possible strategy for the treatment of breast cancer.

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“…44 Different studies have been conducted for the application of HIFU in the treatment of uterine fibroids, in the palliative treatment of pain from bone metastases, and in the treatment of prostate cancer and BPH. [45][46][47] In HIFU, frequencies of 0.8-4 MHz with intensities between 400-10 000 W/cm 2 are used, unlike conventional diagnostic ultrasound, which works at frequencies between 2-15 MHz and intensities of 0.004-7.5 W/cm 2 . The mechanical waves of the HIFU are concentrated by special transducers in the area of interest where the temperature reaches 55 °C causing coagulative necrosis of the affected tissue.…”

Section: High-intensity Focused Ultrasound (Hifu)mentioning

confidence: 99%

Minimally Invasive Treatment in Benign Prostatic Hyperplasia (BPH)

Sciacqua

Vanzulli

Meo

et al. 2023

Technol Cancer Res Treat

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Review efficacy and safety of minimally-invasive treatments for Low Urinary Tract Symptoms (LUTS) in patients affected by Benign Prostate Hyperplasia (BPH). We performed a systematic review of the literature from 1993 to 2022 leveraging original research articles, reviews, and case-studies published in peer-reviewed journals and stored in public repositories. Prostate artery embolization (PAE), transurethral needle ablation (TUNA), transurethral microwave thermotherapy (TUMT), high intensity focused ultrasound (HIFU), laser treatments and Cryoablation are valid and safe alternatives to the gold standard (surgery) in the treatment of LUTS in patients affected by BPH, with fewer undesired effects being reported.

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Optimization of ultrasound array designs for high intensity focused treatment of prostate cancer and benign prostatic hyperplasia

Cited by 8 publications

References 15 publications

Design aspects of focal beams from high-intensity arrays

Design aspects of focal beams from high-intensity arrays

Low‑frequency ultrasound and microbubbles combined with simvastatin promote the apoptosis of MCF‑7 cells by affecting the LATS1/YAP/RHAMM pathway

Minimally Invasive Treatment in Benign Prostatic Hyperplasia (BPH)

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