Optimization of ultrasonic-assisted extraction of antioxidant compounds from blackberry leaves using response surface methodology

Aybastıer, Önder; Işık, Esra; Şahin, Saliha; Demir, Cevdet

doi:10.1016/j.indcrop.2012.09.022

Cited by 82 publications

(50 citation statements)

References 22 publications

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“…This might be due to the fact that phenolic compounds are often more soluble in organic solvents, less polar than water (Meneses et al, 2013). Moreover, the obtained values are in agreement with the content reported in other important antioxidant source by-products that are being studied for antioxidant activity, such as spent coffee grounds (13-35 mg gallic acid equivalents (GAE)/g dry matter) (Mussatto et al, 2011;Panusa et al, 2013), blackberry (50-80 mg GAE/g dry matter) (Aybastıer et al, 2013), brewer's spent grains (9.9 mg GAE/g dry matter) (Meneses et al, 2013), almond shells (38.0 mg GAE/g dry matter) (Sfahlan et al, 2009), or apple pomace, which was below 15 mg GAE/g dry matter (Reis et al, 2012). When comparing the results obtained for CS with the ones for coffee, it is apparent that the coffee waste has a similar phenolic content (Naidu et al, 2008).…”

Section: 36supporting

confidence: 83%

Coffee silverskin: A possible valuable cosmetic ingredient

Rodrigues

Palmeira‐de‐Oliveira

Neves

et al. 2014

Pharmaceutical Biology

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Context: Currently, there is a great tendency in cosmetic area to use natural extracts. Coffee silverskin (CS) is the most abundant solid by-product generated during roasting of coffee processing. Objectives: To evaluate different CS extracts as promising cosmetic ingredients, regarding antioxidant, antimicrobial, and cytotoxic properties. Materials and methods: Aqueous, hydroalcoholic and ethanolic CS extracts were obtained by an environmentally friendly procedure considering costs and pollution. Extracts were characterized for total phenolic and flavonoid contents (TPC and TFC, respectively), antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), antimicrobial activity expressed as minimal inhibitory concentration (MIC) and cytotoxicity using the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) and lactate dehydrogenase (LDH) assays in two skin cell lines (fibroblasts and keratinocytes). Results: The TPC of extracts was 18.33-35.25 mg of gallic acid equivalents per g of material on a dry basis (mg GAE/g db). The TFC of extracts was 1.08-2.47 mg cathechin equivalents per g dry material (mg CE/g db). The antioxidant activity was high, with values ranging between 95.95 and 216.40 mmol Fe 2+ /g for aqueous and alcoholic samples, respectively. Preliminary assays for antimicrobial potential showed that extracts display antibacterial activity. The MIC varied from 31.3 to 250 mg/mL for Gram-positive, and from 31.3 to 1000 mg/mL for Gram-negative. Extracts did not affect in vitro cell viability, with values near 100% in all concentrations tested. Conclusion: Results seem show that CS is a safe source of natural antioxidants with antifungal and antibacterial activity and no cytotoxicity, with potential usefulness for cosmetic applications.

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Section: 36supporting

confidence: 83%

Coffee silverskin: A possible valuable cosmetic ingredient

Rodrigues

Palmeira‐de‐Oliveira

Neves

et al. 2014

Pharmaceutical Biology

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“…The regression analysis on the results obtained from the implementation of these models generates polynomial equations (using the significant values of the estimated regression coefficients), from which the optimal conditions of the process are determined. The main advantage of RSM is the small number of experimental trials required to evaluate the effect of multiple parameters in conjunction with their interactions [47]; it is for this reason that in the process of obtaining polyphenols by means of UAE, this tool has been used in order to maximize extraction yield and the biological activity of the extract. …”

Section: Optimization Of Ultrasonic Assisted Extractionmentioning

confidence: 99%

Ultrasound Assisted Extraction for the Recovery of Phenolic Compounds from Vegetable Sources

Medina-Torres¹,

et al. 2017

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Vegetable sources and agro-industrial residues represent an important source of phenolic compounds that are useful in a wide range of applications, especially those with biological activities. Conventional techniques of phytochemical extraction have been associated with a high consumption of organic solvents that limits the application of bioactive extracts, leading to the implementation of novel extraction technologies using mechanisms such as Ultrasound Assisted Extraction (UAE). In the present review, an analysis of the involved variables in the extraction yield of phenolic compounds through UAE is presented, highlighting the advantages of this technology based on the results obtained in various optimized studies. A comparison with other technologies and a proposal of its possible application for agro industrial residues as raw material of phenolic compounds is also indicated. Finally, it is concluded that UAE is a technology that is placed within the area of Sustainable Chemistry since it promotes the use of renewable raw materials through the extraction of phenolic compounds, implementing the substitution of organic solvents with solvents that do not present toxic effects, lowering the energy consumption when compared to conventional methods and minimizing process times and temperatures, which is useful for the extraction of thermo-labile compounds.

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“…Based on previous studies regarding optimization of ultrasonic-assisted extraction of antioxidant compounds (Aybastıer, Is ßık, S ßahin, & Demir, 2013;Tabaraki & Nateghi, 2011), temperature, methanol volume percent, and sonication time were considered as the design variables.…”

Section: Model Fittingmentioning

confidence: 99%