Optimization of tocotrienols as antiproliferative and antimigratory leads

Behery, Fathy A.; Akl, Mohamed R.; Ananthula, Suryatheja; Parajuli, Parash; Sylvester, Paul W.; Sayed, Khalid A. El

doi:10.1016/j.ejmech.2012.11.012

Cited by 17 publications

(27 citation statements)

References 34 publications

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“…According to preliminary in vitro and in vivo studies, it is also shown to prevent cancer, heart diseases and immune diseases [34,35]. However, supplementation if these oil soluble vitamins through oral route is critical due to their poor aqueous solubility and low absorption [36,37]. Studies are being conducted for effective delivery of these types of supplements in the form of self-emulsifying nano emulsions [38].…”

Section: Self-emulsifying Nanoemulsionsmentioning

confidence: 99%

Nano Formulations of Natural Compounds for Enhanced Delivery

Alam¹

2017

Journal of Diseases

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Section: Self-emulsifying Nanoemulsionsmentioning

confidence: 99%

Nano Formulations of Natural Compounds for Enhanced Delivery

Alam¹

2017

Journal of Diseases

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show abstract

Section: Self-emulsifying Nanoemulsionsmentioning

confidence: 99%

Untitled

2017

Journal of Diseases

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“…Among all the cancers, breast cancer is the mostly studied to evaluate the anticancer activity of tocotrienols [13, [33][34][35]. In one of the studies, tocotrienols displayed potent in vitro anticancer activity against highly malignant +SA mammary cancer cells with minimum toxicity on the normal mammary epithelial cells.…”

Section: Anticancer Activities Of Tocotrienolsmentioning

confidence: 99%

A Brief Journey of Tocotrienols as Anticancer Agents

Kabir¹,

Rahman²,

Rahman³

et al. 2017

J In Silico In Vitro Pharmacol

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The journey of tocotrienol is started when the Vitamin E was first discovered as the fertility factor. Later in the research studies vitamin E was found to be consisting of eight isomers which can be divided into two separate groups known as tocopherols and tocotrienols. The isomers share similarity in structure but differ at much levels based upon their functional or biological properties. Initially tocopherols were investigated much due to their powerful antioxidant properties. However, the other four isomers of tocotrienols were found to be consisting of anticancer properties at varying degree in vitro and in vivo. The mechanisms mediated by tocotrienols such as NFkB pathway, apoptosis, and effect on DNA polymerases are totally different to those of tocopherols.

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Optimization of tocotrienols as antiproliferative and antimigratory leads

Cited by 17 publications

References 34 publications

Nano Formulations of Natural Compounds for Enhanced Delivery

Nano Formulations of Natural Compounds for Enhanced Delivery

Untitled

A Brief Journey of Tocotrienols as Anticancer Agents

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