Optimization of the ultrasonic-assisted extraction process to obtain total phenolic and flavonoid compounds from watermelon (Citrullus lanatus) rind

Vo, Tan Phat; Le, Ngoc Huong Nguyen; Le, Nguyen Phuc Thien; Thanh, Phong; Nguyen, Dinh Quan

doi:10.1016/j.crfs.2022.09.021

Cited by 17 publications

(17 citation statements)

References 33 publications

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“…Pure ethanol and acetone were found to negatively affect the extraction efficiency of phenolics and flavonoids due to protein denaturation and pectin precipitation, hindering solvent diffusion into the plant matrix. 19,20 This trend was in agreement with our previous study, in which we used acetone to extract phenolics and flavonoids from watermelon rinds. 19 Water in the solvent mixture can improve PFP hydration and contact between solvents and materials, increasing the extraction yield of phenolics and flavonoids.…”

Section: Resultssupporting

confidence: 92%

“…19,20 This trend was in agreement with our previous study, in which we used acetone to extract phenolics and flavonoids from watermelon rinds. 19 Water in the solvent mixture can improve PFP hydration and contact between solvents and materials, increasing the extraction yield of phenolics and flavonoids. Meanwhile, ethanol and acetone can break the linkages between target analytes and the plant matrix.…”

Section: Resultssupporting

confidence: 92%

“…The analysis of the polynomial regression models revealed that water had the most significant effect on the extraction efficiency of phenolics and flavonoids, followed by acetone and ethanol for phenolics and ethanol and acetone for flavonoids. Pure ethanol and acetone were found to negatively affect the extraction efficiency of phenolics and flavonoids due to protein denaturation and pectin precipitation, hindering solvent diffusion into the plant matrix. , This trend was in agreement with our previous study, in which we used acetone to extract phenolics and flavonoids from watermelon rinds . Water in the solvent mixture can improve PFP hydration and contact between solvents and materials, increasing the extraction yield of phenolics and flavonoids.…”

Section: Resultssupporting

confidence: 91%

“…Among the three solvents, ethanol and acetone exhibit the higher solubility of phenolics and flavonoids than water because they have similar polarity to these compounds. However, the high concentrations of acetone and ethanol without water can precipitate protein and polysaccharides, impairing the mass transfer and decreasing the recovery yield of phenolics and flavonoids . The dielectric constants of water, ethanol, and acetone are 78.3, 24.3, and 20.7, respectively .…”

Section: Resultsmentioning

confidence: 99%

“…However, the high concentrations of acetone and ethanol without water can precipitate protein and polysaccharides, impairing the mass transfer and decreasing the recovery yield of phenolics and flavonoids. 19 The dielectric constants of water, ethanol, and acetone are 78.3, 24.3, and 20.7, respectively. 6 The high dielectric constant shows that these solvents can absorb microwave irradiation.…”

Section: Effects Of Microwave-assisted Extraction Conditionsmentioning

confidence: 99%

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Optimizing Ultrasonic-Assisted and Microwave-Assisted Extraction Processes to Recover Phenolics and Flavonoids from Passion Fruit Peels

Vo,

Nguyen,

et al. 2023

ACS Omega

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This study optimized the ultrasonic-assisted extraction (UAE) and microwave-assisted extraction (MAE) processes to acquire phenolics and flavonoids from passion fruit peels using a mixture of ethanol, acetone, and water. An augmented simplex− centroid design was employed to find the suitable volume ratio among solvent ingredients to attain the highest extraction yield of phenolics and flavonoids. One-factor experiments were conducted to investigate the influence of UAE and MAE parameters on the recovery yield of phenolics and flavonoids before the two processes were optimized using Box−Behnken Design (BBD) models. The optimal UAE conditions for recovering phenolics and flavonoids from passion fruit peel powder (PFP) were 28 mL/g of liquid-tosolid ratio (LSR), 608 W of ultrasonic power, and 63 °C for 20 min to acquire total phenolic content (TPC) and total flavonoid content (TFC) at 39.38 mg of gallic acid equivalents per gram of dried basis (mg GAE/g db) and 25.79 mg of rutin equivalents per gram of dried basis (mg RE/g db), respectively. MAE conditions for attaining phenolics and flavonoids from PFP were 26 mL/g of LSR and 606 W of microwave power for 2 min to recover TPC and TFC at 17.74 mg GAE/g db and 8.11 mg RE/g db, respectively. The second-order kinetic model was employed to determine the UAE and MAE mechanism of TPC and TFC and the thermodynamic parameters of the extraction processes. The antioxidant activities of passion fruit peel extracts at optimal conditions were examined to compare the efficiency of UAE and MAE. This study establishes an effective approach for obtaining phenolics and flavonoids from passion fruit peels.

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Section: Resultssupporting

confidence: 92%

Section: Resultssupporting

confidence: 92%

Section: Resultssupporting

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Section: Effects Of Microwave-assisted Extraction Conditionsmentioning

confidence: 99%

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Optimizing Ultrasonic-Assisted and Microwave-Assisted Extraction Processes to Recover Phenolics and Flavonoids from Passion Fruit Peels

Vo,

Nguyen,

et al. 2023

ACS Omega

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Quantification and discovery of quality markers from Toddalia asiatica by UHPLC‐MS/MS coupled with chemometrics

Wang,

Yu,

Shang

et al. 2024

Phytochemical Analysis

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IntroductionToddalia asiatica (TA) is a classical traditional Chinese medicine used to treat rheumatoid arthritis and contusions. However, research regarding TA quality control is currently limited.ObjectiveWe aimed to establish a strategy for identifying quality markers that can be used for the evaluation of the quality of TA.MethodA rapid and efficient ultra‐high‐performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry (UHPLC‐MS/MS) method was developed for the quantitative determination of 19 compounds in TA from different regions. Then, the extraction process of TA was successively optimized by single‐factor optimization and response surface methodology. Moreover, chemometrics was employed to confirm the correlation between quality and target compounds.ResultsUtilizing the UHPLC‐MS/MS method, separation of the 19 bioactive compounds was achieved within 14 min. The method was validated in terms of linearity (r2 > 0.9982), precision (0.08%–3.70%), repeatability (0.50%–2.54%), stability (2.26%–5.46%), and recovery (95.8%–113%). The optimal extraction process (extraction solvent, 65% ethanol aqueous solution; solid–liquid ratio, 1:20; extraction time, 25 min) was determined with the total content of 19 bioactive compounds as indicator. Significant disparities were observed in the contents of target compounds across different batches of TA. Besides, all samples could be categorized into two distinct groups, and magnoflorine, (−)‐lyoniresinol, nitidine chloride, norbraylin, skimmianine, and decarine were identified as quality markers.ConclusionIn the present study, we developed a strategy to improve the quality control of TA. In consideration of the pharmacodynamic activity and statistical differences, six compounds are proposed as quality markers for TA.

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Optimization of ultrasound-assisted extraction conditions for the recovery of phenolic compounds from sweet lime peel waste

Thiruvalluvan,

Gupta,

Kaur

2024

Biomass Conv. Bioref.

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Optimization of the ultrasonic-assisted extraction process to obtain total phenolic and flavonoid compounds from watermelon (Citrullus lanatus) rind

Cited by 17 publications

References 33 publications

Optimizing Ultrasonic-Assisted and Microwave-Assisted Extraction Processes to Recover Phenolics and Flavonoids from Passion Fruit Peels

Optimizing Ultrasonic-Assisted and Microwave-Assisted Extraction Processes to Recover Phenolics and Flavonoids from Passion Fruit Peels

Quantification and discovery of quality markers from Toddalia asiatica by UHPLC‐MS/MS coupled with chemometrics

Optimization of ultrasound-assisted extraction conditions for the recovery of phenolic compounds from sweet lime peel waste

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