Optimization of the treatment of anxiety disorders with selank

Medvedev, V. E.; Tereshchenko, Olessya N.; Кост, Н. В.; Ter-Israelyan, A Yu; Gushanskaya, E V; Chobanu, I K; Sokolov, O. Yu.; Myasoedov, N. F.

doi:10.17116/jnevro20151156133-40

Cited by 6 publications

(2 citation statements)

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“…Our findings agree well with the results of clinical studies, as it was shown that the administration of Selank to patients with a simple structure of anxiety and anxiety-asthenic disorders led to a therapeutic efficacy that was comparable to that of benzodiazepine anxiolytics (medazepam and phenazepam) without causing the undesirable side effects that are typical of these drugs, such as sedation, muscle relaxation, development of tolerance, and withdrawal syndrome [ 22 , 23 ]. In addition, as shown by recent studies, the administration of Selank in combination with phenazepam for the treatment of anxiety disorders is probably able to enhance and hasten the onset of the therapeutic effect of phenazepam and reduce the severity of some of its side effects [ 24 ]. It should be noted that the tolerance was not observed after 14 days of Selank administration in the current study.…”

Section: Discussionmentioning

confidence: 99%

Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats

Kasian

Kolomin

Andreeva

et al. 2017

Behavioural Neurology

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It was shown that the anxiolytic effect of Selank is comparable to that of classical benzodiazepine drugs and that the basis of their mechanism of action may be similar. These data suggest that the presence of Selank may change the action of classical benzodiazepine drugs. To test this hypothesis, we evaluated the anxiolytic activity of Selank and diazepam in rats both under conditions of unpredictable chronic mild stress and in its absence, after the individual and combined administration of these compounds using the elevated plus maze test. We found that, even in the absence of chronic stress, the administration of a course of test substances changed anxiety indicators toward their deterioration, but the changes after the administration of a course of Selank were less pronounced. In conditions of chronic stress, anxiety indicator values after the simultaneous use of diazepam and Selank did not differ from the respective values observed before chronic stress exposure. The data obtained indicate that the individual administration of Selank was the most effective in reducing elevated levels of anxiety, induced by the administration of a course of test substances, whereas the combination of diazepam with Selank was the most effective in reducing anxiety in unpredictable chronic mild stress conditions.

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Section: Discussionmentioning

confidence: 99%

Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats

Kasian

Kolomin

Andreeva

et al. 2017

Behavioural Neurology

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“…Данные психопатологические состояния и соматические заболевания находятся в реципрокных соотношениях: каж дое из них способствует прогрессированию и утяжелению другого. Например, обострение сердечно сосудистых забо леваний может провоцировать наступление очередного па роксизма тревоги [3,7,10]. В свою очередь ТР рассматрива ются как независимый фактор риска развития, неблагопри ятного течения и исхода сердечно сосудистых заболеваний, а также смертности [8].…”

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Anxiety Disorders in General Medical Practice

Dzyak

Tsurakalenko

2016

FMEP

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Timely diagnosis and early initiation of adequate therapy of disorders of the alarming spectrum (AS) remains one of the urgent tasks of modern medicine. The article considers aspects of diagnosis and treatment of AS in General medical network, particularly were described the currently recommended schemes of application of the drug Eglonil and benefits of this drug. Eglonil demonstrates the possibility of wide application of different variants of anxiety disorders, which gives the drug a special status among other psychotropic compounds.

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