Optimization of the Synthesis and Conjugation of the Methyl Rhamnan Tip of Pseudomonas aeruginosa A-Band Polysaccharide and Immunogenicity Evaluation for the Continued Development of a Potential Glycoconjugate Vaccine
Mohammad P. Jamshidi,
Chantelle Cairns,
Nam Huan Khieu
et al.
Abstract:Pseudomonas aeruginosa is an antimicrobial-resistant
bacterium that has no vaccine approved for human use. Additionally,
it has been identified by the World Health Organization as a priority
pathogen for novel vaccines and therapeutic development. We previously
developed a synthetic mimic of the A-band polysaccharide tip that
showed promise in terms of immunogenicity for use as a glycoconjugate
vaccine. In this current manuscript, we improve upon the previous
work to continue the development of this glycoconju… Show more
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