Optimization of Tb3+/Gd3+ Molar Ratio for Rapid Detection of Naja Atra Cobra Venom by Immunoglobulin G-Conjugated GdPO4·nH2O : Tb3+ Nanorods

Lien, Pham Thi; Huong, Nguyen Thanh; Hương, Trần Thu; Khuyen, Hoang Thi; Ánh, Nguyễn Thị Ngọc; Văn, Nguyễn Đức; Tuấn, Nguyễn Ngọc; Nghia, Vu Xuan; Minh, Le Quoc

doi:10.1155/2019/3858439

Cited by 6 publications

(3 citation statements)

References 34 publications

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“…These characteristics are also very useful potential objects for application in highly functional devices. Some rare earth containing luminescent nanorods could be synthesized by wet chemical routes [19][20][21] including our successful work with TbPO 4 nanorods [22]. These results and some other previous studies have shown that the morphology of materials can have important impacts on luminescent intensity.…”

Section: Introductionmentioning

confidence: 57%

Folic Acid-Conjugated Silica-Modified TbPO4·H2O Nanorods for Biomedical Applications

Vinh

Hương

Phuong

et al. 2021

Journal of Nanomaterials

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We report on the synthesis and characterization of folic acid-conjugated silica-modified TbPO4·H2O nanorods for biomedical applications. The uniform shape TbPO4·H2O nanorods with a hexagonal phase were successfully synthesized by wet chemical methods. A novel TbPO4·H2O@silica-NH2 nanocomplex was then formed by functionalizing these nanorods with silica and conjugating with biological agents. The field emission scanning electron microscopy, energy-dispersive X-ray, and X-ray diffraction reveal the morphology and structure of the nanorods, with their controllable sizes (500-800 nm in length and 50-80 nm in diameter). The Fourier transform infrared spectroscopy was employed to identify chemical substances or functional groups of the TbPO4·H2O@silica-NH2 nanocomplex. The photoluminescence spectra show the four emission lines of TbPO4·H2O@silica-NH2 in folic acid at 488, 540, 585, and 621 nm under 355 nm laser excitation, which could be attributed to the 5D4-7 F j ( J = 6 , 5 , 4 , 3 ) transitions of Tb3+. The TbPO4·H2O@silica-NH2 nanorods were conjugated with folic acid for the detection of MCF7 breast cancer cells. The obtained results show a promising possibility for the recognition of living cells that is of crucial importance in biolabeling.

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Section: Introductionmentioning

confidence: 57%

Folic Acid-Conjugated Silica-Modified TbPO4·H2O Nanorods for Biomedical Applications

Vinh

Hương

Phuong

et al. 2021

Journal of Nanomaterials

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“…The quite different significant utilization of the downconversion and upconversion emission RE luminescence nanomaterials from fundamentals to frontier applications suggested or developed [27][28][29][30]. The optimization of Tb 3+ /Gd 3+ ratio in nanorods for rapid detection of naja atra cobra venom was indicated [31]. The critical review of stochastic optical reconstruction microscopy (STORM), NaYF 4 :Yb 3+ /Er 3+ @silica-TPGS Complexes, for theranostics issued [21,[32][33][34].…”

Section: Resultsmentioning

confidence: 99%

Optic bionanospherical probe from Gd\(_2\)O\(_3\): Yb, Er upconverting nanosphere and mAb^CD133 antibody for precise imaging label of cancer stem cell NTERA-2

Nguyen

Trong

et al. 2023

Comm. Phys.

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Rare earth photonic nanomaterials are increasingly prominently applied in various fields of biomedicine. Currently, there is greater focus on the investigation to control the size and shape of nanomaterials, including the nanospherical form, which allows for precise labeling by only one nanoparticle. This paper demonstrates, for the first time, the construction of a biological nanospherical probe (BNSP) Gd2O3: Yb3+, Er3+/Silica/NH/mAb^CD133 for diagnostic labeling of cancer stem cells (CSCs) NTERA-2. The BNSP was constructed using highly monodisperse spheres with around 200nm uniform size of Gd2O3: 7.6% Yb3+, 1.6% Er3+. They were functionalized by an amine group-contained shell coating and conjugated with CD133 monoclonal antibody. The functionalized nanosphere Gd2O3: Yb, Er/silica/NH2 showed strong upconversion luminescence in red color upon laser excitation in the near-infrared region at 975 nm. The Gd2O3: Yb3+, Er3+/silica/NH2 was carefully implemented to conjugate mAb^CD133 via a linker, glutaraldehyde, to obtain the predictable probe Gd2O3: Yb3+, Er3+/Silica/NH/mAb^CD133. Then, this BNSP was tested in vitro for its capacity to label NTERA-2 cancer stem cells. The efficient labeling based on the fluorescent immunoassay method was detected by incorporating a nanophotometer, Field Energy Scan Electron Microscopy (FESEM), and precisely determined by fluorescent microscopy. The study shows that the BNSP is highly efficient with targeting capacity and specificity in the labeling of cancer stem cells. These advanced results open up promising avenues for the development of precise imaging diagnostics in cancer cellular biomedicine, and beyond.

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“…Trong những thập niên gần đây, công nghê nano đóng vai trò rất quan trọng trong một số lĩnh vực như quang xúc tác, thiết bị hiển thị, pin năng lượng mặt trời, dẫn truyền thuốc, công nghệ LED [1][2][3][4][5][6]. Trong đó, GdPO 4 pha tạp ion đất hiếm là một số những vật liệu được nghiên cứu rất nhiều vì GdPO 4 là mạng nền có độ ổn định về nhiệt và hóa học cao.…”

Section: Giới Thiệu Chungunclassified

Synthesis & PL study of GdPO4:Tb,Eu nanophosphor

Dieu¹,

Duc²,

Duc³

et al. 2021

vietnam j. catal. adsorpt.

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Tb3+ and Eu3+ ions co-doped containing monoclinic GdPO4 nanocrystals were successfully obtained by a straightforward combustion method. The crystal structure and optical characteristics were investigated by methods: XRD, photoluminescence spectra (PL). The XRD result indicates the GdPO4:10%Tb, x%Eu had monoclinic phase and the average particle size was about 10 nm. Under excitation wavelength at 394 nm, photoluminescent emission spectra of GdPO4:10%Tb, x%Eu nanopowders show strong characteristic emission of Eu3+ ions and no characteristic emission of Tb3+ ions was found. However, under the excitation of 273 nm or 368 nm, the emission spectra of the samples were shown characteristic emission of Tb3+ ions with 5D4 - 7FJ (J=3-6) transitions and Eu3+ ions with 5D0-7FJ (J=0-4) transitions.

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Optimization of Tb³⁺/Gd³⁺ Molar Ratio for Rapid Detection of Naja Atra Cobra Venom by Immunoglobulin G-Conjugated GdPO₄·nH₂O : Tb³⁺ Nanorods

Cited by 6 publications

References 34 publications

Folic Acid-Conjugated Silica-Modified TbPO4·H2O Nanorods for Biomedical Applications

Folic Acid-Conjugated Silica-Modified TbPO4·H2O Nanorods for Biomedical Applications

Optic bionanospherical probe from Gd\(_2\)O\(_3\): Yb, Er upconverting nanosphere and mAb^CD133 antibody for precise imaging label of cancer stem cell NTERA-2

Synthesis & PL study of GdPO4:Tb,Eu nanophosphor

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