Optimization of taste-masking on ibuprofen microspheres with selected structure features

Qin, Wei; He, Yuanzhi; Guo, Zhen; Zhang, Liu; Wu, Li; Yin, Xianzhen; Shakya, Shailendra; Maharjan, Abi; Tang, Yuzhe; Zhu, Weifeng; Zhang, Jiwen

doi:10.1016/j.ajps.2018.05.003

Cited by 17 publications

(8 citation statements)

References 29 publications

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“…(a,d) 3D image and cavity of single air-cooling microsphere; (b,e) 3D image and cavity of single water-cooling microsphere; (c,f) 3D image and cavity of the single citric acid solution-cooling microsphere. Reproduced with permission from ref . Copyright 2018 Elsevier.…”

Section: Discovery Of 3d Structures In Ddssmentioning

confidence: 99%

Advances in Structure Pharmaceutics from Discovery to Evaluation and Design

Xue

et al. 2023

Mol. Pharmaceutics

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Drug delivery systems (DDSs) play an important role in delivering active pharmaceutical ingredients (APIs) to targeted sites with a predesigned release pattern. The chemical and biological properties of APIs and excipients have been extensively studied for their contribution to DDS quality and effectiveness; however, the structural characteristics of DDSs have not been adequately explored. Structure pharmaceutics involves the study of the structure of DDSs, especially the three-dimensional (3D) structures, and its interaction with the physiological and pathological structure of organisms, possibly influencing their release kinetics and targeting abilities. A systematic overview of the structures of a variety of dosage forms, such as tablets, granules, pellets, microspheres, powders, and nanoparticles, is presented. Moreover, the influence of structures on the release and targeting capability of DDSs has also been discussed, especially the in vitro and in vivo release correlation and the structure-based organ- and tumor-targeting capabilities of particles with different structures. Additionally, an in-depth discussion is provided regarding the application of structural strategies in the DDSs design and evaluation. Furthermore, some of the most frequently used characterization techniques in structure pharmaceutics are briefly described along with their potential future applications.

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Section: Discovery Of 3d Structures In Ddssmentioning

confidence: 99%

Advances in Structure Pharmaceutics from Discovery to Evaluation and Design

Xue

et al. 2023

Mol. Pharmaceutics

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“…For instance, Qin et al compared the structure and morphology of ibuprofen microspheres cooled by different cooling media (wind, water, and citric acid) under the same preparation method. They found that the condensed sphericity of the microspheres in the citric acid solution was higher, the surface was smoother, the shape was more regular, and the taste-masking effect was better. , The reason behind it is that the solubility of ibuprofen in a citric acid medium is lower than that of in a water medium, which can effectively avoid the rough surface and irregular shape caused by the dissolution of ibuprofen. Compared with the wind medium, it can effectively reduce the cooling time and take shape faster.…”

Section: Concentration-intensity Taste Maskingmentioning

confidence: 99%

Strategies for Taste Masking of Orodispersible Dosage Forms: Time, Concentration, and Perception

Xie

et al. 2022

Mol. Pharmaceutics

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Orodispersible dosage forms, characterized as quick dissolving and swallowing without water, have recently gained great attention from the pharmaceutical industry, as these forms can satisfy the needs of children, the elderly, and patients suffering from mental illnesses. However, poor taste by thorough exposure of the drugs’ dissolution in the oral cavity hinders the effectiveness of the orodispersible dosage forms. To bridge this gap, we put forward three taste-masking strategies with respect to the intensity of time, concentration, and perception. We further investigated the raw material processing, the composition of auxiliary material, formulation techniques, and process control in each strategy and drew conclusions about their effects on taste masking.

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“…Additionally, transmission electron microscopy (TEM), confocal microscopy, and other advanced techniques can be applied for the investigation of the external and internal morphology of the MPs. Recently, synchrotron radiation X-ray micro-computed tomography (SR-μCT), a powerful non-invasive technique, was used for the study of the internal three dimensional structure of spray congealed MPs containing ibuprofen [53]. This method allowed the determination of interior porous channels and irregular structures of the MPs.…”

Section: Properties and Characterization Of Spray Congealed Sdmentioning

confidence: 99%

Spray Congealing: An Emerging Technology to Prepare Solid Dispersions with Enhanced Oral Bioavailability of Poorly Water Soluble Drugs

2019

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The low and variable oral bioavailability of poorly water soluble drugs remains a major concern for the pharmaceutical industry. Spray congealing is an emerging technology for the production of solid dispersion to enhance the bioavailability of poorly soluble drugs by using low-melting hydrophilic excipients. The main advantages are the absence of solvents and the possibility to obtain spherical free-flowing microparticles (MPs) by a relatively inexpensive, simple, and one-step process. This review aims to fully describe the composition, structure, physico-chemical properties, and characterization techniques of spray congealed-formulations. Moreover, the influence of these properties on the MPs performance in terms of solubility and dissolution enhancement are examined. Following, an overview of the different spray congealed systems developed to increase the oral drug bioavailability is provided, with a focus on the mechanisms underpinning the bioavailability enhancement. Finally, this work gives specific insights on the main factors to be considered for the rational formulation, manufacturing, and characterization of spray congealed solid dispersions.

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Optimization of taste-masking on ibuprofen microspheres with selected structure features

Cited by 17 publications

References 29 publications

Advances in Structure Pharmaceutics from Discovery to Evaluation and Design

Advances in Structure Pharmaceutics from Discovery to Evaluation and Design

Strategies for Taste Masking of Orodispersible Dosage Forms: Time, Concentration, and Perception

Spray Congealing: An Emerging Technology to Prepare Solid Dispersions with Enhanced Oral Bioavailability of Poorly Water Soluble Drugs

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